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PVRIG Protein (AA 41-171) (Fc Tag)

PVRIG Origine: Cynomolgus Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7275504
  • Antigène Voir toutes PVRIG Protéines
    PVRIG (Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 41-171
    Origine
    • 13
    • 4
    • 2
    Cynomolgus
    Source
    • 16
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette PVRIG protéine est marqué à la Fc Tag.
    Fonction
    Cynomolgus PVRIG Protein
    Séquence
    Thr41-Asp171
    Attributs du produit
    Recombinant Cynomolgus PVRIG Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Thr41-Asp171.
    Pureté
    > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine
    Less than 1EU per μg by the LAL method.
    Biological Activity Comment
    Immobilized Cynomolgus PVRIG, hFc Tag at 0.1μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Anti-PVRIG Antibody, hFc Tag with the EC50 of 5.4ng/ml determined by ELISA. The affinity constant of 0.23 μM as determined in SPR assay (Biacore T200). See testing image for detail.
    Top Product
    Discover our top product PVRIG Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
    Buffer
    Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    PVRIG (Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG))
    Autre désignation
    PVRIG (PVRIG Produits)
    Synonymes
    C7orf15 Protein, PVR related immunoglobulin domain containing Protein, PVRIG Protein
    Sujet
    PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family.PVRIG is a cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
    Poids moléculaire
    40.3 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
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