SLC22A13 Protein (AA 1-551) (His tag)

N° du produit ABIN7551615

Protéine Recombinant SLC22A13 exprimée dans HEK-293 Cells.

Aperçu rapide pour SLC22A13 Protein (AA 1-551) (His tag) (ABIN7551615)

Antigène: SLC22A13 (Solute Carrier Family 22 (Organic Anion Transporter), Member 13 (SLC22A13))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Classe de qualité: custom-made

Détail du produit

Attributs du protein: AA 1-551

Purification/Conjugué: Cette SLC22A13 protéine est marqué à la His tag.

Fonction: Predefined custom protein recombinant SLC22A13 Protein expressed in mammalian cells.

Séquence: MAQFVQVLAE IGDFGRFQIQ LLILLCVLNF LSPFYFFAHV FMVLDEPHHC AVAWVKNHTF NLSAAEQLVL SVPLDTAGHP EPCLMFRPPP ANASLQDILS HRFNETQPCD MGWEYPENRL PSLKNEFNLV CDRKHLKDTT QSVFMAGLLV GTLMFGPLCD RIGRKATILA QLLLFTLIGL ATAFVPSFEL YMALRFAVAT AVAGLSFSNV TLLTEWVGPS WRTQAVVLAQ CNFSLGQMVL AGLAYGFRNW RLLQITGTAP GLLLFFYFWA LPESARWLLT RGRMDEAIQL IQKAASVNRR KLSPELMNQL VPEKTGPSGN ALDLFRHPQL RKVTLIIFCV WFVDSLGYYG LSLQVGDFGL DVYLTQLIFG AVEVPARCSS IFMMQRFGRK WSQLGTLVLG GLMCIIIIFI PADLPVVVTM LAVVGKMATA AAFTISYVYS AELFPTILRQ TGMGLVGIFS RIGGILTPLV ILLGEYHAAL PMLIYGSLPI VAGLLCTLLP ETHGQGLKDT LQDLELGPHP RSPKSVPSEK ETEAKGRTSS PGVAFVSSTY F Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificité: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Attributs du produit: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Information d'application

Indications d'application: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -80 °C

Stockage commentaire: Store at -80°C.

Date de péremption: 12 months

Détail du antigène

Antigène: SLC22A13 (Solute Carrier Family 22 (Organic Anion Transporter), Member 13 (SLC22A13))

Autre désignation: SLC22A13

Sujet: Solute carrier family 22 member 13 (Organic anion transporter 10) (OAT10) (Organic cation transporter-like 3) (ORCTL-3) (ORCTL3),FUNCTION: Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions (PubMed:18411268, PubMed:35144162, PubMed:31780526, PubMed:35462902). Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption (PubMed:18411268, PubMed:35144162, PubMed:31780526). Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption (PubMed:18411268, PubMed:35144162). Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate (PubMed:18411268). Urate and orotate transports are Cl(-)-dependent (PubMed:35144162, PubMed:35462902). Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable). {ECO:0000269|PubMed:18411268, ECO:0000269|PubMed:31780526, ECO:0000269|PubMed:35144162, ECO:0000269|PubMed:35462902, ECO:0000305|PubMed:35144162, ECO:0000305|PubMed:35462902}.

Poids moléculaire: 60.9 kDa

UniProt: Q9Y226

AlphaFold: Q9Y226