APH1B Protein (AA 1-257) (His tag)

N° du produit ABIN7559187

Protéine Recombinant APH1B exprimée dans HEK-293 Cells.

Aperçu rapide pour APH1B Protein (AA 1-257) (His tag) (ABIN7559187)

Antigène: APH1B (Aph1b) (Anterior Pharynx Defective 1 Homolog B (Aph1b))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Classe de qualité: custom-made

Détail du produit

Attributs du protein: AA 1-257

Purification/Conjugué: Cette APH1B protéine est marqué à la His tag.

Fonction: Predefined custom protein recombinant Aph1b Protein expressed in mammalian cells.

Séquence: MTAAVFFGCA FIAFGPALAL YVFTIATDPL RVIFLIAGAF FWLVSLLLSS VFWFLVRVIT DNRDGPVQNY LLIFGVLLSV CIQELFRLAY YKLLKKASEG LKSINPEETA PSMRLLAYVS GLGFGIMSGV FSFVNTLSNS LGPGTVGIHG DSPQFFLNSA FMTLVVIMLH VFWGVVFFDG CEKNKWYTLL TVLLTHLVVS TQTFLSPYYE VNLVTAYIIM VLMGIWAFYV AGGSCRSLKL CLLCQDKDFL LYNQRSR Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificité: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Attributs du produit: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Information d'application

Indications d'application: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -80 °C

Stockage commentaire: Store at -80°C.

Date de péremption: 12 months

Détail du antigène

Antigène: APH1B (Aph1b) (Anterior Pharynx Defective 1 Homolog B (Aph1b))

Autre désignation: Aph1b

Sujet: Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta),FUNCTION: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A (By similarity). {ECO:0000250}.

Poids moléculaire: 28.7 kDa

UniProt: Q8C7N7

AlphaFold: Q8C7N7

Pathways: Signalisation Notch, Neurotrophin Signaling Pathway