BVES Protein (AA 1-358) (His tag)

N° du produit ABIN7565060

Cette protéine Recombinant BVES est exprimée dans HEK-293 Cells.

Aperçu rapide pour BVES Protein (AA 1-358) (His tag) (ABIN7565060)

Antigène: BVES (Blood Vessel Epicardial Substance (BVES))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Classe de qualité: custom-made

Détail du produit

Attributs du protein: AA 1-358

Purification/Conjugué: Cette BVES protéine est marqué à la His tag.

Fonction: Predefined custom protein recombinant Bves Protein expressed in mammalian cells.

Séquence: MNSTESIPLA QSTVAGFTSE LESLTPVPSN ETTCENWREI HHLVFHVANV CFAVGLLIPT TLHLHMILLR VMLSLGCTLY VVWATLYRCA LDVMIWNSVF LGINILHLSY LLYKKRPVKI EKELGGVYHR LFEPLRVPPD LFRRLTGQFC MIQTLKRGQV YATEDKTSVD DRLSILLKGR MKVSYRGHFL HNIYPCAFID SPEFRSTQMH KGEKFQVTIV ADDNCRFLCW SRERLTYFLE SEPFLYEIFR YLIGKDITNK LYSLNDPTLN DKKVKKLEPQ MSLCTQISML EMRNSITSSS DGEDGLHHFL RGSSSTASLP MSSPQQRASA KMKPIEEGVE DDDEVFVSPD ALKVHQLP Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificité: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Attributs du produit: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Information d'application

Indications d'application: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -80 °C

Stockage commentaire: Store at -80°C.

Date de péremption: 12 months

Détail du antigène

Antigène: BVES (Blood Vessel Epicardial Substance (BVES))

Autre désignation: Bves

Sujet: Blood vessel epicardial substance (mBVES) (Popeye domain-containing protein 1) (Popeye protein 1),FUNCTION: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3 (PubMed:20057356). Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT (PubMed:18541910). Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (PubMed:11839816). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury (PubMed:24066022). {ECO:0000250|UniProtKB:Q8NE79, ECO:0000269|PubMed:10882522, ECO:0000269|PubMed:11839816, ECO:0000269|PubMed:16188940, ECO:0000269|PubMed:18541910, ECO:0000269|PubMed:20057356, ECO:0000269|PubMed:22354168, ECO:0000269|PubMed:24066022}.

Poids moléculaire: 41.0 kDa

UniProt: Q9ES83

AlphaFold: Q9ES83