FZD10 Protein (AA 21-225) (hIgG-His-tag)

N° du produit ABIN7678149

Cette protéine Recombinant FZD10 est exprimée dans HEK-293 Cells.

Aperçu rapide pour FZD10 Protein (AA 21-225) (hIgG-His-tag) (ABIN7678149)

Antigène: FZD10 (Frizzled Family Receptor 10 (FZD10))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Application: SDS-PAGE (SDS)

Pureté: > 90 %

Détail du produit

Attributs du protein: AA 21-225

Purification/Conjugué: Cette FZD10 protéine est marqué à la hIgG-His-tag.

Séquence: ISSMDMERPG DGKCQPIEIP MCKDIGYNMT RMPNLMGHEN QREAAIQLHE FAPLVEYGCH GHLRFFLCSL YAPMCTEQVS TPIPACRVMC EQARLKCSPI MEQFNFKWPD SLDCRKLPNK NDPNYLCMEA PNNGSDEPTR GSGLFPPLFR PQRPHSAQEH PLKDGGPGRG GCDNPGKFHH VEKSASCAPL CTPGVDVYWS REDKR

Purification: > 90% by SDS-PAGE

niveau d'endotoxine: < 1 EU per 1ug of protein (determined by LAL method)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) containing 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: FZD10 (Frizzled Family Receptor 10 (FZD10))

Autre désignation: Frizzled-10

Sujet: Frizzled-10, also known as CD350, is a member of the G-protein coupled receptor Fz/Smo family. Frizzled-10 is expressed during embryogenesis in the primitive streak, dorsal neural tube, developing brain, limb bud, and airway epithelium. In the adult, it is expressed in placenta, gastric glands, and colon and renal tubule epithelial cells. It is a receptor for Wnt proteins and up-regulated in some cancers and transformed cell lines. Frizzled-10 associates with LRP5 to transduce Wnt 7a and Wnt 7b signals, resulting in the stabilization of cytoplasmic beta-catenin. Expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. It may also be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis or in differentiated tissues. Recombinant human Frizzled-10, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Poids moléculaire: 50kDa (444aa)

NCBI Accession: NP_009128

Pathways: Signalisation WNT