Glial Cell Line Derived Neurotrophic Factor (GDNF) (Active) Protéine

Détails pour le produit réf. ABIN780532
Nom de la protéine
  • gdnf
  • GDNF
  • AI385739
  • gdnfa
  • hfb1-gdnf
  • ATF1
  • ATF2
  • HFB1-GDNF
  • HSCR3
  • glial cell derived neurotrophic factor
  • glial cell derived neurotrophic factor a
  • glial cell line derived neurotrophic factor
  • glial cell derived neurotrophic factor L homeolog
  • Gdnf
  • gdnfa
  • GDNF
  • gdnf.L
Origine
Humain
40
16
15
1
1
Source
Escherichia coli (E. coli)
56
4
3
2
1
1
1
1
1
Type de proteíne
Recombinant
Activité biologique
Active
Application
In vitro Assay (in vitro), In vivo Studies (in vivo), ELISA, Western Blotting (WB)
Options
Séquence MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI
Specificité Recombinant human GDNF is a non-glycosylated homodimer, containing two 135 amino acid chains, with a total molecular weight of 30.4 kDa.
Pureté ≥ 95%
Stérilité 0.2 μm filtered
niveau d'endotoxine ≤ 1.00 LAL (EUs/ug)
Biological Activity Comment
  • Bioactivity Assay: C6 cell proliferation
  • Bioactivity Acceptance Criteria ED50 (ng/ml): 3 ug/mL
  • Bioactivity Acceptance Criteria (Units/mg): 3.3 x 10^2 units/mg
Nom de la protéine
Sujet Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that signals through a multicomponent receptor system to activate receptor tyrosine kinase RET signaling. GDNF promotes dopamine uptake, prevents motor neuron apoptosis, and supports the survival and differentiation of neurons.

Alternate Names: ATF-1
Poids moléculaire Dimer: 15.2/30.4 MW Monomer/Total (kDa)
UniProt P39905
Pathways Signalisation RTK, Synaptic Membrane, Tube Formation, Autophagy, Smooth Muscle Cell Migration
Indications d'application Optimal working dilution should be determined by the investigator.
Commentaires

Media Components: Luria Broth

Restrictions For Research Use only
Format Lyophilized
Reconstitution Sterile water at 0.1 mg/mL
Buffer Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing : 10 mM sodium citrate, 100 mM sodium chloride,  pH 4.0
Agent conservateur Without preservative
Conseil sur la manipulation Centrifuge vial before opening.
Stock 4 °C,-20 °C,-80 °C
Stockage commentaire 12 months from date of receipt when stored at -20°C to-80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.
Date de péremption 12 months
Images (Fournisseur)
 image for Glial Cell Line Derived Neurotrophic Factor (GDNF) (Active) protein (ABIN780532) Glial Cell Line Derived Neurotrophic Factor (GDNF) (Active) protein
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