IL1RN Protéine

N° du produit ABIN988019

Détail du produit

Antigène: IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Séquence: MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ ED

Attributs du produit: Fully biologically active when compared to standard. The ED50 determined by inhibiting IL-1alpha-dependent proliferation of murine D10S cells is less than 0.5 ng/ml, corresponding to a specific activity of >, 2.0 × 106 IU/mg in the presence of 50pg/ml rHuIL-1alpha.

Pureté: > 95 % by SDS-PAGE and HPLC analyses.

niveau d'endotoxine: Level Less than 1EU/µg of rHuIL-1ra as determined by LAL method

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Stock: 4 °C

Référence

Hedl, Abraham: "Nod2-induced autocrine interleukin-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines." dans: Gastroenterology, Vol. 143, Issue 6, pp. 1530-43, (2012) (PubMed).

Détail du antigène

Antigène: IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))

Autre désignation: Interleukin-1 receptor antagonist (IL-1ra) (IL1RN Produits)

Synonymes: DIRA Protein, ICIL-1RA Protein, IL-1RN Protein, IL-1ra Protein, IL-1ra3 Protein, IL1F3 Protein, IL1RA Protein, IRAP Protein, MVCD4 Protein, IRAP1 Protein, IL1RN Protein, IL-1RA Protein, F630041P17Rik Protein, interleukin 1 receptor antagonist Protein, interleukin 1 receptor antagonist-like Protein, IL1RN Protein, Il1rn Protein, IL1RNL Protein

Sujet: Interleukin-1 receptor antagonist (IL-1ra) is a member of the IL-1 family. Endogenous IL-1ra is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL1-ra.The regulated expression of IL1ra in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts the synthesis of IL-1ra is markedly enhanced by IL-1 , TNF-alpha , or PDGF. Synonym: Interleukin-1 receptor antagonist (IL-1ra), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Poids moléculaire: Approximately 17.0 kDa, a single non-glycosylated polypeptide chain containing 153 amino acids.

Pathways: Signalisation NF-kappaB, Hormone Transport, Cancer Immune Checkpoints