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Both gamma and delta subunits silenced cells displayed decreased ATP synthase function - lowered rate of ADP-stimulated respiration, a two-fold increased sensitivity of respiration to inhibitor oligomycin, and impaired utilization of mitochondrial membrane potential for ADP phosphorylation.
Studies indicate that F1-ATPase (F1) is a rotary motor protein driven by ATP hydrolysis and the minimum complex of F1 for function as a rotary motor is the alpha3beta3gamma subcomplex.
These results demonstrated that the 5'-AGUUCCA-3' immediately downstream from ESE is a muscle-specific (Montrer EIF3K Protéines) exonic splicing silencer (MS-ESS) responsible for exclusion of exon 9 in vivo and in vitro
A report on the mechanism of exon skipping regulated by Fox-1 (Montrer A2BP1 Protéines), using the hF1gamma gene as a model system.
molecular dynamic analysis of interaction between the gamma-subunit and a C-terminal fragment of the beta-subunit of F1-ATPase
direction of F1-ATPase subunit gamma rotation
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14.
ATP synthase gamma chain, mitochondrial
, ATP synthase subunit gamma, mitochondrial
, F-ATPase gamma subunit
, mitochondrial ATP synthase, gamma subunit 1
, ATP synthase gamma-subunit gene encoding a mitochondrial protein
, F1 gamma