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Human Monoclonal CTPS Primary Antibody pour ELISA, WB - ABIN560531
David, Ittner, Gehrig, Nergenau, Shepherd, Halliday, Götz: Beta-amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes. dans Proteomics 2006
Show all 2 Pubmed References
CTPS1 inhibition selectively blocks smooth muscle cell proliferation without disturbing or even promoting re-endothelialization for effective vascular repair after injury.
Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
Data show that CTP synthase 1a (ctps1a) is more critical throughout the initial period of embryonic development than CTP synthase 1b (ctps1b).
CTP synthase forms the cytoophidium in human hepatocellular carcinoma.
The filament structures elucidate allosteric mechanisms of assembly and regulation that rely on a conserved conformational equilibrium. The findings may provide a mechanism for increasing human CTP synthase activity in response to metabolic state and challenge the assumption that metabolic filaments are generally storage forms of inactive enzymes.
Rods and rings (RR) are protein assemblies composed of CTPS1 and IMPDH2. Glutamine deprivation initiates reversible assembly of mammalian rods and rings.
results highlight a key and specific role of CTPS1 in the immune system by its capacity to sustain the proliferation of activated lymphocytes during the immune response
analysis of the kinetic properties of hCTPS1 and hCTPS2, and determination that Ser(68) is a major site of CTPS2 regulation by phosphorylation
CTP synthetase is phosphorylated by protein kinase A
Data indicate that protein kinase C phosphorylation at Ser(462) stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr(455) inhibits activity.
analysis of phosphorylation and regulation of human CTPS1 in human cells shows that GSK3 is a novel regulator of CTPS activity
studies provide novel information on the potential interacting proteins that may regulate CTPS1 function or intracellular localization
The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types
, CTP synthase 1
, CTP synthetase 1
, UTP--ammonia ligase 1
, cytidine 5'-triphosphate synthase
, CTP synthase 1-B
, CTP synthetase 1-B
, UTP--ammonia ligase 1-B
, CTP synthase a
, cytidine 5'-triphosphate synthetase
, cytidine 5-prime triphosphate synthetase
, CTP synthase 1-like
, CTP synthetase