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The expression of NHE3 in the rumen of sheep and cattle and its role in sodium transport are reported.
Lysophosphatidic acid stimulation of NHE3 exocytosis includes a signaling pathway that regulates fixation of NHE3 to the microvillar cytoskeleton.
1) NHE3 basal activity is regulated by a signaling complex that is controlled by sequential effects of two kinases, Akt and GSK-3, which act on a Ser cluster in the same NHE3 C-terminal domain that binds ezrin
CaMKII binding to and phosphorylation of the NHE3 C terminus are parts of the physiologic regulation of NHE3 that occurs in fibroblasts as well as in the brush border of an intestinal Na(+)-absorptive cell.
Regulation of NHE3 depends on the nature of the NHERF family member associating with NHE3 and the accompanying NHE3 complexes.
We demonstrate that NHE3-799C is a common variant of NHE3 that is enriched in Asian populations; however its presence seems to have limited clinical significance in humans and is not associated with compromised function or abnormal transport regulation.
This review focuses on novel findings of NHE3 in the intestine and the kidney as well as novel drug developments targeting NHE3. [review]
NHE3 binds to NHERF proteins via both an internal Class II PBM and C-terminal Class I PBM, which interact. The former determines NHE3 stability in the PM, and the latter determines total expression and percent PM expression.
Expression of NHE3 and DRA was reduced with high tacrolimus levels and impaired renal function after intestinal transplantation.
Recessive mutations in NHE3, a downstream target of GC-C, caused congenital sodium diarrhea and implied primary basal NHE3 malfunction as a predisposition for inflammatory bowel disease in a subset of patients.
CCH-mediated inhibition of NHE3 activity is not dependent on clathrin and involves lipid rafts and requires Cdc42.
Inflammation-induced loss of PDZK1 expression may contribute to the NHE3 dysfunction observed in the inflamed intestine.
Data demonstrate a role for Per1 in the transcriptional regulation of NHE3 and SGLT1 in the kidney.
Results demonstrate decreased transport activity in three SNPs of NHE3 and provide mechanistic insight into how these SNPs impact NHE3 function.
these findings indicate the importance of NHE3 in diabetic diarrhea and suggest LPA administration as a potential therapeutic strategy for management of diabetic diarrhea.
NHE3 may play a role in the pathogenesis of human cholesterol gallstone disease
Study identifies RSK2 as a new kinase that regulates NHE3 activity by direct phosphorylation.
the three NHE3 SNPs are unlikely to play a major role in the pathogenesis of SIDS in Caucasian infants;further genetic investigations in different ethnicities are required to determine whether variations in NHE3 are associated with an increased SIDS risk
C. difficile inhibits NHE3 in vivo, which creates an altered environment favored by C. difficile.
Myosin VI mediates the movement of NHE3 to the microvillus in intestinal epithelial cells.
PKC-eta associates with NHE3 and gamma tubulin to promote the cell polarity during migration.
Human NHE3, but not non-primates NHE3s, is ubiquitinated by Nedd4-2.
NHE3 can act as a direction sensor for cells and that NHE3 phosphorylation in persistent directional cell migration does not involve PI3K/Akt during electrotaxis.
Data suggest that NHE3 expression is significantly decreased in term placenta of patients with pre-eclampsia as compared to normotensive patients; NHE3 is almost undetectable in cytosol of preeclamptic syncytiotrophoblasts.
We propose that ouabain can simultaneously regulate renal tubule basolateral Na(+)-K(+)-ATPase and apical NHE3, leading to inhibition of transepithelial Na(+) transport.
displays Na+/H+ exchanger transport activity\; mediates sodium ion transport across the renal proximal tubule
sodium proton exchanger
, sodium/hydrogen exchanger 3
, solute carrier family 9 (sodium/hydrogen exchanger), member 3
, sodium/hydrogen exchanger 3 (nhe3)
, Sodium/hydrogen exchanger 3
, Na(+)/H(+) exchanger 3
, Na+/H+ exchanger homolog
, solute carrier family 9 member 3
, Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive)
, plasma membrane ion transport protein
, solute carrier family 9, member 3
, solute carrier family 9 (sodium/hydrogen exchanger)
, sodium/hydrogen exchanger