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Human SLC9A3R1 Protein expressed in HEK-293 Cells - ABIN2732190
Wang, Qin, Zhu: Expression of Na+/H+ exchanger regulatory factor 1 in autosomal-dominant polycystic kidney disease. dans The Journal of international medical research 2015
Low NHERF1 expression is associated with hypophosphatemia in calcium stone formers.
NHERF1 was found to be downregulated by HPV16 E6 rather than by HPV18 E6, leading to enhancement of ACTN4-mediated actin cytoskeleton organization, motility and invasion of cervical cancer cells both in vitro and in vivo. Thus, the enhancement of cell migration and invasion induced by HPV16 E6-mediated degradation of NHERF1 might be an important cause of cervical cancer carcinogenesis.
NHERF1 role in the colorectal cancer apoptosis.CTNNB1 represses NHERF1 expression by associating with TCF4 in colorectal cancer.
DNMT1 contributes to promoter hypermethylation and epigenetic NHERF1 silencing in colon cancer.
found that NHERF1 was associated with trophoblast differentiation and motility; stepwise experimental platform to explore new functions of ambiguously denoted candidate proteins
High expression of NHERF-1 is associated with triple-negative breast cancer.
Taken together, these findings suggest that the high dynamics of cytosolic NHERF1 provide cancer cells with a means of controlling chemotactic migration.
Studies support a role for NHERF-1 and NHERF-2 (Na+/H+ exchanger regulatory factors 1 and 2) in regulating the distribution of Group II metabotropic glutamate receptor (mGluRs) in the murine brain, while conversely the effects of the mGluR2/3 PDZ-binding motifs on receptor signaling are likely mediated by interactions with other PDZ scaffold proteins beyond the NHERF proteins.
The up-regulation of NHERF1 induced by the exposure to hypoxia in colon cancer cells depends on the activation of VEGFR2 signaling.
-catenin was predominantly associated with Na+/H+ exchanger regulating factor 1 (NHERF1) in a dynamic context and an increase of its oncogenic function through RAS-association domain family 1, isoform A (RASSF1A) inactivation in liver metastases.
Na+/H+ exchanger regulatory factor (NHERF1) expression level positively associates with G protein-coupled estrogen receptor (GPER) activation in ER-positive breast cancer.
The present results suggest a role for NHERF1 in the progression of breast cancer mediated by the nuclear distribution of the NHERF1 protein, as determined by the truncation or key site mutation of the PDZ-I domain.
NF2 localizes in nucleus when Ser518 is not phosphorylated, while phosphorylated form is present in cytoplasm and plasma membrane. Data suggest that binding of NF2 to TIMAP and EBP50 is critical in nuclear localization of NF2. (NF2 = neurofibromin 2; TIMAP = TGF-beta-inhibited membrane-associated protein; EBP50 = Ezrin-Radixin-Mosein binding phosphoprotein 50)
NHERF1/EBP50 encompasses the regulation of several major signaling pathways engaged in cancer, including the receptor tyrosine kinases PDGFR and EGFR, PI3K/PTEN/AKT and Wnt-beta-catenin pathways.
Data demonstrated that EBP50 overexpression inhibited the adhesion and migration of breast and cervical cancer cell lines and suppressed MMP-2 activity in these cells; while its knockdown promoted cell adhesion and migration, and enhanced the activity of MMP-2.This study reveals the anti-metastatic effect and a new mechanism of EBP50 action in breast and cervical cancer cells.
Data provide evidence for an important role of NHERF1 in the epithelial-mesenchymal transition of non-small-cell lung cancer cells, as well as migration.
This interaction is promoted by EPAC1 activation, triggering its translocation to the plasma membrane and binding to NHERF1. Our findings identify a new CFTR-interacting protein and demonstrate that cAMP activates CFTR through two different but complementary pathways - the well-known PKA-dependent channel gating pathway and a new mechanism regulating endocytosis that involves EPAC1.
we show here that NHERF1 loss from the PM is oncogenic in vivo through its influence on Wnt-APC-beta-catenin and Hippo-YAP pathways.
High EBP50 expression is associated with cervical cancer.
Using neutron spin echo spectroscopy (NSE), the authors show salt-concentration-dependent excitation of nanoscale motion at the tip of the C-terminal tail in the phosphomimic S339D/S340D mutant.
Along with several single loci, the epistatic QTLs, SLC9A3R1 and NOS2 control for total number of piglets born and number of piglets born alive in a F(2) Iberian by Meishan intercross.
Results strongly support an important role for NHERF1 in the regulation of Planar Cell Polarity signaling and the development of functional motile cilia.
our data identify EBP50 as a previously unidentified regulator of Nox1 and support that it promotes Nox1 activity by binding p47(phox) This interaction is pivotal for agonist-induced smooth muscle ROS, hypertrophy, and vasoconstriction and has implications for ROS-mediated physiological and pathophysiological processes.
The results provide evidence that NHERF1 mediates K(+) current activity through acceleration of the surface expression of ROMK1 K(+) channels in M-1 cells.
The NHERF1 is as putative molecular organizer of signal transduction in vomeronasal neurons.
NHERF1 mediates ANG II-induced activation of renal NHE3, which requires coordination between IRBIT and the NHERF1 PDZ1 domain in binding and transporting NHE3
These results indicate that PTH-mediated inhibition of renal phosphate transport involves phosphorylation of S77 of the NHERF-1 PDZ I domain and the dissociation of NHERF-1/Npt2a complexes.
the activation of PTEN and NHERF-1 may impede the evolution of macrophages beyond the M1 into M2 phenotype in tumor microenvironment.
Data show that interaction of the inducible nitric oxide synthase (iNOS) C-terminus with the PDZ domains of EBP50 protein or Pdzk1 protein CAP70 resulted greater nitric oxide (NO) synthesis.
The expression of EBP50 was not significantly different in the pseudopregnant uterus and decreased in the uteri subjected to activation of delayed implantation.
NHERF1 is differentially distributed to rafts and non-raft brush border membrane fractions of NHE3.
EBP50 expression is induced by inflammatory stimuli and potentiates NF-kappaB activation and inflammation in primary macrophages and VSMC.
siRNA knockdown of PEX7 reduced iNOS colocalization with the peroxisomal protein PMP70. Proteomic studies using MALDI-MS identified iNOS association with the 50-kD ezrin binding PDZ protein (EBP50).
EBP50 promotes focal adhesion turnover and vascular smooth muscle cells migration.
NHERF1 regulates PTH that differentially affects Na-dependent Pi transport at distinct stages of osteoblast proliferation and maturation
NHERF1 is required for normal osteoblast differentiation and matrix synthesis. In its absence, compensatory mechanisms maintain bone mass, but bone strength is reduced.
NHERF1 engages prolactin receptor in structural complexes that maintain the polarity and directional signaling via STAT5 activation, through expression upregulation and strategic localization at the basal membrane of alveolar cells.
that NHERF1 associates with NaPi-2b in enterocytes and regulates NaPi-2b adaptation.
EBP50 is critical for neointima formation and induces vascular smooth muscle cell proliferation by decreasing S-phase kinase protein2 stability, thereby accelerating the degradation of the cell cycle inhibitor p21(cip1).
Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone.
study found mainly nuclear localization of EBP50 in interphase cells, and its redistribution to cytoplasm during mitosis parallel with its phosphorylation; PP2A was identified as an interacting protein of EBP50 during pro-, prometa-, meta-, ana-, telophase, and early cytokinesis
This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
, Na+/H+ exchange regulatory co-factor
, ezrin-radixin-moesin binding phosphoprotein-50
, ezrin-radixin-moesin-binding phosphoprotein 50
, regulatory cofactor of Na(+)/H(+) exchanger
, solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1
, solute carrier family 9 isoform A3 regulatory factor 1
, sodium-hydrogen exchanger regulatory factor 1
, solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
, solute carrier family 9 sodium/hydrogen exchanger member 3 regulator 1
, solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2
, solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1
, ERM-binding phosphoprotein
, Na(+)/H(+) exchange regulatory cofactor NHE-RF
, solute carrier family 9 isoform 3 regulatory factor 1
, NHE3 kinase A regulatory protein 1
, SLC9A3 regulator 1 S homeolog
, solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 S homeolog