Recommendations are based on data provided indicating:
ELISA Kit Sensitivity
The recommended ELISA Kit will likely detect the antigen better in the approved sample types than the available alternatives.
ELISA Kit Specificity
The recommended ELISA Kit will likely detect the antigen in question with higher specificity in approved samples than the available alternatives.
The results will be likely more reproducible, with high inter- or intra-assay CV and Recovery (for values within the std curve) than the available alternatives.
ELISA Kit Robustness
The recommended assay will likely function better with approved sample types, and will not suffer from undue matrix interference than the available alternatives.
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LIG4 Antigen Profile
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
Alternative names and synonyms associated with LIG4
ligase IV, DNA, ATP-dependent (lig4) ELISA Kit
DNA ligase 4 (LIG4) ELISA Kit
DNA ligase 4 (LOC100212302) ELISA Kit
DNA ligase 4 (CpipJ_CPIJ005161) ELISA Kit
DNA ligase 4 (PTRG_09982) ELISA Kit
DNA ligase 4 (MCYG_05151) ELISA Kit
DNA ligase 4 (LOC657210) ELISA Kit
ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining (LIG4) ELISA Kit
DNA ligase IV (ATLIG4) ELISA Kit
ligase IV, DNA, ATP-dependent L homeolog (lig4.L) ELISA Kit
ligase IV, DNA, ATP-dependent (Lig4) ELISA Kit
DNA ligase 4 (Lig4) ELISA Kit
zgc:165595 ELISA Kit
lig4 ELISA Kit
DNA LIGASE IV ELISA Kit
LIG4 ELISA Kit
lig4-A ELISA Kit
5830471N16Rik ELISA Kit
tiny ELISA Kit
DNL4 ELISA Kit
Protein level used designations for LIG4
DNA ligase 4
, ligase IV, DNA, ATP-dependent
, DNA ligase IV
, DNA ligase (ATP) 4
, ligase4-like protein
, DNA ligase 4-like
, dsDNA break repair ligase
, polydeoxyribonucleotide synthase [ATP] 4
, DNA joinase
, DNA repair enzyme
, polynucleotide ligase