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MGMT promoter methylation was determined by methylation-specific polymerase chain reaction
MGMT methylation is a prognostic factor in newly diagnosed glioblastoma. In this study, we evaluated the rate of change of MGMT methylation during the clinical course of the disease, and we found a significant concordance between the first and the second MGMT methylation assessments, with MGMT methylation being stable in 75% of the cases
Findings show the cell-context dependent effects of PRIMA (Montrer PRIMA1 Protéines)-1MET irrespective of p53 (Montrer TP53 Protéines) status and suggest the role of O6-methylguanine-DNA methyltransferase (MGMT) as a potential molecular target of PRIMA (Montrer PRIMA1 Protéines)-1MET in MGMT-positive glioblastoma stem cell (GSCs).
MGMT methylation assay, of which PSQ appeared to be the best, could improve the predictive power for Glioblastoma patients with MGMT IHC- tumors
Both blood and tumor tissue MGMT and ERCC1 (Montrer ERCC1 Protéines) methylation were associated with cancer rectum.
MGMT promoter methylation may be an early biomarker for the diagnosis of breast cancer (Meta-Analysis)
Low MGMT expression assessed by immunochemistry in temozolomide-treated patients with pancreatic neuroendocrine tumors is associated with radiological objective response and increased progression-free survival.
Rs16906252C>T is associated with elevated risk for MGMT-methylated colorectal cancer.
Treatment of metastatic colorectal cancer (mCRC) with temozolomide driven by MGMT promoter hypermethylation in AT samples did not provide meaningful PFS rate at 12 weeks. This biomarker changed from AT to BT, indicating that testing BT biopsy or plasma is needed for refined target selection
the MGMT promoter homozygous rs1625649 (AA genotype) was found to correlate with a better PFS in patients with MGMT methylated glioblastoma
Snell, GHKRO, and PAPPA (Montrer PAPPA Protéines)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1 (Montrer NDRG1 Protéines)).
This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG (Montrer C16orf35 Protéines), as a key node in determining a carcinogenic threshold.
Findings suggest that O6-methylguanine-DNA methyltransferase (MGMT)-mediated temozolomide resistance is associated with increased histone acetylation.
Loss of MGMT expression and high Ezrin (Montrer EZR Protéines) protein expression leads to esophageal cancer.
Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.
ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa.
Roles of MGMT and MLH1 (Montrer MLH1 Protéines) proteins in alkylation-induced apoptosis and mutagenesis.
Repression of MGMT is associated with precancerous conditions in hyperplastic mucosa adjacent to colon cancer
GAMT (Montrer GAMT Protéines) and AGAT (Montrer GATM Protéines) mRNA are up-regulated 5.4- and 1.9-fold respectively in adult mdx (Montrer DMD Protéines) muscle compared to C57
MGMT-deficient cells would likely exhibit an increased mutational burden, but only following exposures to specific environmental mutagens such as the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a
, O6-methylguanine-DNA methyltransferase
, methylated-DNA--protein-cysteine methyltransferase
, methylguanine-DNA methyltransferase
, O-6-alkylguanine-DNA alkyltransferase
, 0-6-methylguanine-DNA methyltransferase
, O(6)-alkylguanine-DNA alkyltransferase
, O6-alkylguanine-DNA alkyltransferase
, O6-methylguanine-DNA methyltranferase