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The mechanism by which RAD52 depletion causes synthetic lethality in BRCA1 mutant cancer cells depends on the 5' endonuclease EEPD1, which normally functions to cleave stressed replication forks to initiate HR repair.
inhibition of ataxia telangiectasia mutated (ATM (Montrer ATM Protéines)) protein by siRNA or inhibitor treatment demonstrated that the acetylation of RAD52 at DSB sites is dependent on the ATM (Montrer ATM Protéines) protein kinase (Montrer CDK7 Protéines) activity, through the formation of RAD52, p300/CBP (Montrer CREBBP Protéines), SIRT2 (Montrer SIRT2 Protéines), and SIRT3 (Montrer SIRT3 Protéines) foci at DSB sites
n a cohort of patients with typical symptoms of ischemic heart disease, a common single nucleotide polymorphism of the human RAD52 gene has a role in increased hazard of death, showing that it may influence aging
RAD52 gene polymorphism is associated with colorectal cancer.
our study demonstrated that RAD52 polymorphisms were associated with colorectal cancer in a Chinese Han cohort
DNA-bound RAD52 is efficient at capturing ssDNA in trans.
Structure of the human DNA-repair protein RAD52 containing surface mutations has been reported.
Rad52 inverse strand exchange plays an important role in RNA-templated double strand break repair in vivo.
The mitotic DNA synthesis is RAD52 dependent, and RAD52 is required for the timely recruitment of MUS81 (Montrer MUS81 Protéines) and POLD3 (Montrer POLD3 Protéines) to common fragile sites in early mitosis.
Human RAD52-null cells retain a significant level of single-strand annealing (SSA (Montrer TRIM21 Protéines)) activity demonstrating perforce that additional SSA (Montrer TRIM21 Protéines)-like activities must exist in human cells. Moreover, the SSA (Montrer TRIM21 Protéines) activity associated with RAD52 is involved in, but not absolutely required for, most homology-directed repair (HDR (Montrer GATA3 Protéines)) subpathways. Specifically, a deficiency in RAD52 impaired the repair of DNA DSBs.
Results demonstrate that Rad52 depletion increased cell death, decreased myeloid cell frequency, and augmented the activity of CD8 (Montrer CD8A Protéines)+ T cells and NK effectors that ultimately led to reduced tumor growth. These data provide support for the notion of RAD52 as a potential oncogene (Montrer RAB1A Protéines), implicating a major role for the combined processes of recombinational repair and host immunity in determining risk for Squamous Cell.
In cancer-prone, heterozygous APC (Montrer APC Protéines) mutant mice, homozygous deletion of the Rad52 gene suppressed tumor growth and prolonged lifespan.
Rad54 (Montrer RAD54L Protéines) has a key function in maintaining genomic integrity of the developing germ cells.
Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm (Montrer ATM Protéines)-deficient mice.
RAD52 modulates the outcome of recombinant HIV-l vector infection by markedly reducing the efficiency of productive integration events
Inactivation of RAD52 aggravates X-ray and mitomycine C sensitivity in mice with RAD54 (Montrer RAD54L Protéines) gene degect.
Cells expressing Rad52 splice variants favor sister chromatid repair.
Results indicate that RAD52 cooperates with OGG1 (Montrer OGG1 Protéines) to repair oxidative DNA damage and enhances the cellular resistance to oxidative stress.
The complete cDNA sequences of the pig RAD51 (Montrer RAD51 Protéines), RAD52, and RAD54 (Montrer RAD54L Protéines) genes, which are closely related to homologous recombination events, arae identified using molecular cloning technique in pigs.
Rad51 (Montrer RAD51 Protéines) and Rad52 physically interact with CENP-ACaCse4 in vivo.
Rad52 prevents chromosome loss and truncation.
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair.
DNA repair protein RAD52 homolog
, recombination protein RAD52
, rhabdomyosarcoma antigen MU-RMS-40.23
, RAD52 homolog (S. cerevisiae)
, RAD52 homolog isoform alpha
, DNA repair protein RAD52
, DNA repair protein RAD52 homolog-like
, RAD52 homolog
, potential dsDNA break repair annealing factor
, DNA repair and recombination protein, putative
, RAD52 protein