Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher tous les synonymes
Sélectionnez vos espèces d'intérêt
RAD52 gene polymorphism is associated with colorectal cancer.
our study demonstrated that RAD52 polymorphisms were associated with colorectal cancer in a Chinese Han cohort
DNA-bound RAD52 is efficient at capturing ssDNA in trans.
Structure of the human DNA-repair protein RAD52 containing surface mutations has been reported.
Rad52 inverse strand exchange plays an important role in RNA-templated double strand break repair in vivo.
The mitotic DNA synthesis is RAD52 dependent, and RAD52 is required for the timely recruitment of MUS81 (Montrer MUS81 Protéines) and POLD3 (Montrer POLD3 Protéines) to common fragile sites in early mitosis.
Human RAD52-null cells retain a significant level of single-strand annealing (SSA (Montrer TRIM21 Protéines)) activity demonstrating perforce that additional SSA (Montrer TRIM21 Protéines)-like activities must exist in human cells. Moreover, the SSA (Montrer TRIM21 Protéines) activity associated with RAD52 is involved in, but not absolutely required for, most homology-directed repair (HDR (Montrer GATA3 Protéines)) subpathways. Specifically, a deficiency in RAD52 impaired the repair of DNA DSBs.
Data suggest RAD52 binds tightly to RPA (Montrer RPA1 Protéines)/ssDNA complex in presynaptic complex and inhibits RPA (Montrer RPA1 Protéines) turnover; during presynaptic complex assembly, most of RPA (Montrer RPA1 Protéines) and RAD52 is displaced from ssDNA, but some RAD52/RPA (Montrer RPA1 Protéines)/ssDNA complexes persist as interspersed clusters surrounded by RAD51 (Montrer RAD51 Protéines) filaments. (RAD52 = Rad52 DNA repair/recombination protein (Montrer RAD50 Protéines); RPA (Montrer RPA1 Protéines) = replication protein A (Montrer GPR153 Protéines); ssDNA = single-stranded DNA; RAD51 (Montrer RAD51 Protéines) = Rad51 (Montrer RAD51 Protéines) recombinase (Montrer RAG1 Protéines))
The C-terminal region of yRad52, but not of hRAD52, is involved in ssDNA annealing. This suggests that the second DNA binding site is required for the efficient ssDNA annealing by yRad52. We propose an updated model of Rad52-mediated ssDNA annealing.
Study discovered two cis (Montrer CISH Protéines)-expression quantitative trait loci SNPs in the RAD52 gene that are associated with its expression and are also associated with lung squamous cell carcinomas (LUSC) risk.
In cancer-prone, heterozygous APC (Montrer APC Protéines) mutant mice, homozygous deletion of the Rad52 gene suppressed tumor growth and prolonged lifespan.
Rad54 (Montrer RAD54L Protéines) has a key function in maintaining genomic integrity of the developing germ cells.
Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm (Montrer ATM Protéines)-deficient mice.
RAD52 modulates the outcome of recombinant HIV-l vector infection by markedly reducing the efficiency of productive integration events
Inactivation of RAD52 aggravates X-ray and mitomycine C sensitivity in mice with RAD54 (Montrer RAD54L Protéines) gene degect.
Cells expressing Rad52 splice variants favor sister chromatid repair.
Results indicate that RAD52 cooperates with OGG1 (Montrer OGG1 Protéines) to repair oxidative DNA damage and enhances the cellular resistance to oxidative stress.
The complete cDNA sequences of the pig RAD51 (Montrer RAD51 Protéines), RAD52, and RAD54 (Montrer RAD54L Protéines) genes, which are closely related to homologous recombination events, arae identified using molecular cloning technique in pigs.
Rad51 (Montrer RAD51 Protéines) and Rad52 physically interact with CENP-ACaCse4 in vivo.
Rad52 prevents chromosome loss and truncation.
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair.
DNA repair protein RAD52 homolog
, recombination protein RAD52
, rhabdomyosarcoma antigen MU-RMS-40.23
, RAD52 homolog (S. cerevisiae)
, RAD52 homolog isoform alpha
, DNA repair protein RAD52
, DNA repair protein RAD52 homolog-like
, RAD52 homolog
, potential dsDNA break repair annealing factor
, DNA repair and recombination protein, putative
, RAD52 protein