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Human Monoclonal ALOX15 Primary Antibody pour IHC (p), ELISA - ABIN513270
Calandria, Marcheselli, Mukherjee, Uddin, Winkler, Petasis, Bazan: Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1. dans The Journal of biological chemistry 2009
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Human Monoclonal ALOX15 Primary Antibody pour FACS, IF - ABIN2715951
Fredman, Li, Dalli, Chiang, Serhan: Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. dans Scientific reports 2012
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Cow (Bovine) Polyclonal ALOX15 Primary Antibody pour WB - ABIN2786489
McCaskie, Beilby, Hung, Chapman, McQuillan, Powell, Thompson, Palmer: 15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness. dans Human genetics 2008
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Human Polyclonal ALOX15 Primary Antibody pour WB - ABIN513269
Leconet, Petit, Peraldi-Roux, Bresson: Nonviral delivery of small interfering RNA into pancreas-associated immune cells prevents autoimmune diabetes. dans Molecular therapy : the journal of the American Society of Gene Therapy 2012
Human Polyclonal ALOX15 Primary Antibody pour ELISA, WB - ABIN449570
McDuffie, Maybee, Keller, Stevens, Garmey, Morris, Kropf, Rival, Ma, Carter, Tersey, Nunemaker, Nadler: Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. dans Diabetes 2007
Pinosylvin enhances the apoptosis of LPS (Montrer IRF6 Anticorps) preconditioned leukocytes by up-regulating ALOX 15 expression through ERK (Montrer EPHB2 Anticorps) and JNK (Montrer MAPK8 Anticorps).
indicate regulation of Alox15 mRNA expression in neuroblastoma (Montrer ARHGEF16 Anticorps) cells by histone modifications, and increasing Alox15 expression in differentiating neurons
The present study shows that rs7217186:C > T and rs2619112:G > A of ALOX15 are associated with increased risk of CAD (Montrer CAD Anticorps) in the North Indian population.
Results identify ALOX15, which was upregulated under low oxygen conditions and is associated with an increase in the rate of phagocytosis of apoptotic cells.
15-LOX-1 expression in colon and prostate cancer cells leads to reduced angiogenesis. These changes could be mediated by an increase in the expression of both ICAM-1 and the anti-angiogenic protein TSP-1.
Polymorphisms in the ALOX15 gene may influence periodontal disease pathogenesis. Hence, investigation of such polymorphisms could benefit the evaluation of lipoxins role in periodontal disease
Results suggest an evolution of ALOX15 (12/15-lipoxygenase)specificity.
Compound heterozygous mutations in DYNC2H1 (Montrer DYNC2H1 Anticorps) and ALOX15 were identified in miscarriages from two families with RPL. DYNC2H1 (Montrer DYNC2H1 Anticorps) is involved in cilia biogenesis and has been associated with fetal lethality in humans. ALOX15 is expressed in placenta and its dysregulation has been associated with inflammation, placental, dysfunction, abnormal oxidative stress response and angiogenesis.
Immunofluorescence analyses revealed that the ALOX15 protein consistently localizes to cell membrane during the course of ferroptosis. Importantly, treatments of cells with ALOX15-activating compounds accelerated cell death at low, but not high doses of erastin and RSL3
present in late-stage germ cells of the testis
upregulation of ALOX15 occurring in response to oxidative stress in germ cells of the male mouse leads to enhanced 4-hydroxynonenal production and subsequent pathways of deleterious protein modification
The data provide the first evidence to date that small molecules that target 12/15-LOX can prevent progression of beta-cell dysfunction and glycemic deterioration in models of type 1 diabetes.
Findings suggest a pivotal role for 12/15-lipoxygenase (12/15-LOX) in both caspase (Montrer CASP3 Anticorps)-dependent and caspase (Montrer CASP3 Anticorps)-independent apoptotic pathways following global cerebral ischemia and suggest a novel therapeutic approach to reduce brain injury following cardiac arrest.
The present study investigated the roles of arachidonate 15-lipoxygenase (Alox15) in the clearance of dying adipocytes by adipose tissue macrophages.
data support that endothelial, rather than monocytic/macrophagic, 12/15-LO has a critical role in hyperglycemia-induced ICAM-1 (Montrer ICAM1 Anticorps) expression, leukocyte adhesion, and subsequent local retinal barrier dysfunction.
This study determined that 1) deletion of 12/15-lipoxygenase (LOX (Montrer LOX Anticorps)) promotes the generation of epoxyeicosatrienoic acids, the cytochrome P-450 (Montrer CYP Anticorps)-derived metabolites in postmyocardial infarction (post-MI) healing; 2) acute exposure of fatty acids to 12/15-LOX(-/-) mice drives leukocyte (neutrophils and macrophages) clearance post-MI; and 3) metabolic transformation of fats is the significant contributor in leukocyte clearance
These data suggest that systemic inactivation of the Alox15 gene normalizes the reduced fertility of male Sec46Ala-Gpx4(+/-) mice by improving the motility of their sperm. If these data can be confirmed in humans, ALOX15 inhibitors might counteract male infertility related to GPX4 deficiency.
The 12/15-LOX plays an important role in the metabolism of eicosanoids in response to allergen-induced airway inflammation.
12/15-LO-derived oxidized lipids regulate histone modifications associated with profibrotic gene expression in MCs (Montrer SMCP Anticorps), and 12/15-LO can mediate similar actions of TGF-beta1 (Montrer TGFB1 Anticorps) and diabetes.
The crystal structure of a mammalian 12-lipoxygenase reveals a plausible substrate access channel for oxygen.
12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter (Montrer ABCA13 Anticorps) G1.
EPR (Montrer EREG Anticorps) spectroscopy and electrospray mass spectroscopy reveal distinctive features of the iron site in leukocyte arachidonate 12-lipoxygenase (Montrer ALOX12 Anticorps).
Results indicate 15-lipoxygenase modified LDL as a new inducer for LOX-1 (Montrer OLR1 Anticorps) expression and as a new ligand for LOX-1 (Montrer OLR1 Anticorps).
demonstrates 12-lipoxygenase and some 15-lipoxygenase enzyme activity
, arachidonate omega-6 lipoxygenase
, arachidonate 15-lipoxygenase
, arachidonate 12-lipoxygenase, leukocyte-type
, arachidonate 12-lipoxygenase, 12S-type
, Arachidonate 15-lipoxygenase
, erythroid cell-specific 15-lipoxygenase
, omega-6 lipoxygenase
, arachidonate lipoxygenase, epidermal