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Human Monoclonal ALOX15 Primary Antibody pour IHC (p), ELISA - ABIN513270
Calandria, Marcheselli, Mukherjee, Uddin, Winkler, Petasis, Bazan: Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1. dans The Journal of biological chemistry 2009
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Human Monoclonal ALOX15 Primary Antibody pour FACS, IF - ABIN2715951
Fredman, Li, Dalli, Chiang, Serhan: Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. dans Scientific reports 2012
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Human Polyclonal ALOX15 Primary Antibody pour ELISA, WB - ABIN449570
McDuffie, Maybee, Keller, Stevens, Garmey, Morris, Kropf, Rival, Ma, Carter, Tersey, Nunemaker, Nadler: Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. dans Diabetes 2007
Human Polyclonal ALOX15 Primary Antibody pour WB - ABIN513269
Leconet, Petit, Peraldi-Roux, Bresson: Nonviral delivery of small interfering RNA into pancreas-associated immune cells prevents autoimmune diabetes. dans Molecular therapy : the journal of the American Society of Gene Therapy 2012
Cow (Bovine) Polyclonal ALOX15 Primary Antibody pour WB - ABIN2786489
McCaskie, Beilby, Hung, Chapman, McQuillan, Powell, Thompson, Palmer: 15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness. dans Human genetics 2008
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ALOX15 orthologs, commonly known as 12/15-lipoxygenases, were suggested to exhibit mainly arachidonic acid 12-lipoxygenating specificity in mammals ranked in evolution lower than gibbons and 15-lipoxygenating specificity in the higher ranking primates [Review].
Study in the dextran sulfate sodium colitis model utilizing transgenic mice overexpressing human ALOX15 suggests a pro-inflammatory activity of human 15-LOX1.
Pinosylvin enhances the apoptosis of LPS preconditioned leukocytes by up-regulating ALOX 15 expression through ERK and JNK.
indicate regulation of Alox15 mRNA expression in neuroblastoma cells by histone modifications, and increasing Alox15 expression in differentiating neurons
The present study shows that rs7217186:C > T and rs2619112:G > A of ALOX15 are associated with increased risk of CAD in the North Indian population.
Results identify ALOX15, which was upregulated under low oxygen conditions and is associated with an increase in the rate of phagocytosis of apoptotic cells.
the results indicate that 15-LO-1 has an important role in the disease progression of osteoarthritis. Thus 15-LO-1 may be a good target for developing drugs in the treatment of osteoarthritis.
15-LOX-1 expression in colon and prostate cancer cells leads to reduced angiogenesis. These changes could be mediated by an increase in the expression of both ICAM-1 and the anti-angiogenic protein TSP-1.
Polymorphisms in the ALOX15 gene may influence periodontal disease pathogenesis. Hence, investigation of such polymorphisms could benefit the evaluation of lipoxins role in periodontal disease
Results suggest an evolution of ALOX15 (12/15-lipoxygenase)specificity.
Compound heterozygous mutations in DYNC2H1 and ALOX15 were identified in miscarriages from two families with RPL. DYNC2H1 is involved in cilia biogenesis and has been associated with fetal lethality in humans. ALOX15 is expressed in placenta and its dysregulation has been associated with inflammation, placental, dysfunction, abnormal oxidative stress response and angiogenesis.
Immunofluorescence analyses revealed that the ALOX15 protein consistently localizes to cell membrane during the course of ferroptosis. Importantly, treatments of cells with ALOX15-activating compounds accelerated cell death at low, but not high doses of erastin and RSL3
present in late-stage germ cells of the testis
Studied human umbilical cord mesenchymal stem cell (hucMSCs) transplantation in DSS-induced inflammatory bowel disease (IBD); hucMSC transplantation significantly relieved IBD symptoms thru the regulation of 15-LOX-1 expression and modulation of inflammatory responses in macrophages.
Findings suggest that 12/15-lipoxygenase (12/15-LO)-mediated enzymatic lipid oxidation serves as a key mechanism controlling eosinophil-directed coagulation and physiological hemostasis.
These results indicated that 15-LOX-1 is a potential target for inhibiting the trafficking of DCs to lymphoid organs and inflamed tissues and decreasing the inflammatory response attenuating symptoms of certain immunologic and inflammatory disorders such as dermatitis.
Kelavkar and Badr (1999) stated that the ALOX15 gene maps to 17p13.3 in close proximity to the tumor-suppressor gene TP53 and stated that the ALOX15 gene product is implicated in antiinflammation, membrane remodeling, and cancer development/metastasis.
we propose that increased ALOX15 expression in heart tissue under ischemic conditions may lead to increased production of 15-HETE, potentially contributing to thrombosis.
the results of the present study indicated that the natural products, CA, quercetin and morin hydrate, offer potential as adjuvant therapeutic agents for SMinduced toxicity, not only by reducing inflammation mediated by the p38 and LOX signaling pathways, but also by decreasing the generation of ROS and nitrate/nitrite.
15-LOX-1 re-expression downregulates the expression of MTA1 in colorectal cancer cell lines.
The data demonstrate that the db/db mouse is a suitable model for investigation of 12/15LO inhibitors in the development of inflammatory mediated type 2 diabetes, with a narrow window of therapeutic intervention prior to 8 weeks of age.
a specific endogenous metabolite of vitamin E, alpha-tocopherol hydroquinone, was a dramatically more potent inhibitor of ferroptosis than its parent compound, and inhibits 15-lipoxygenase via reduction of the enzyme's non-heme iron from its active Fe3+ state to an inactive Fe2+ state.
Alox15 exhibits pro-inflammatory activity in the dextran sulfate sodium mouse colitis model as indicated by genetic loss- and gain-of-function strategies.
Deletion of 12/15-lipoxygenase accelerates the development of aging-associated and instability-induced osteoarthritis.
upregulation of ALOX15 occurring in response to oxidative stress in germ cells of the male mouse leads to enhanced 4-hydroxynonenal production and subsequent pathways of deleterious protein modification
The data provide the first evidence to date that small molecules that target 12/15-LOX can prevent progression of beta-cell dysfunction and glycemic deterioration in models of type 1 diabetes.
Findings suggest a pivotal role for 12/15-lipoxygenase (12/15-LOX) in both caspase-dependent and caspase-independent apoptotic pathways following global cerebral ischemia and suggest a novel therapeutic approach to reduce brain injury following cardiac arrest.
The present study investigated the roles of arachidonate 15-lipoxygenase (Alox15) in the clearance of dying adipocytes by adipose tissue macrophages.
data support that endothelial, rather than monocytic/macrophagic, 12/15-LO has a critical role in hyperglycemia-induced ICAM-1 expression, leukocyte adhesion, and subsequent local retinal barrier dysfunction.
This study determined that 1) deletion of 12/15-lipoxygenase (LOX) promotes the generation of epoxyeicosatrienoic acids, the cytochrome P-450-derived metabolites in postmyocardial infarction (post-MI) healing; 2) acute exposure of fatty acids to 12/15-LOX(-/-) mice drives leukocyte (neutrophils and macrophages) clearance post-MI; and 3) metabolic transformation of fats is the significant contributor in leukocyte clearance
These data suggest that systemic inactivation of the Alox15 gene normalizes the reduced fertility of male Sec46Ala-Gpx4(+/-) mice by improving the motility of their sperm. If these data can be confirmed in humans, ALOX15 inhibitors might counteract male infertility related to GPX4 deficiency.
The 12/15-LOX plays an important role in the metabolism of eicosanoids in response to allergen-induced airway inflammation.
12/15-LO-derived oxidized lipids regulate histone modifications associated with profibrotic gene expression in MCs, and 12/15-LO can mediate similar actions of TGF-beta1 and diabetes.
In experimental postoperative ileus, 12/15-lipoxygenase was expressed, mainly in CX3CR1(+)/Ly6C(+) infiltrating monocytes, not Ly6G(+) neutrophils. 12/15-LOX mediates ileus resolution by producing proresolving docosahexaenoic acid-derived protectin DX.
we show that oxidized phospholipids generated by 12/15-LOX can act as substrates for key proteins required for effective autophagy and that cells deficient in this enzyme show evidence of autophagic dysfunction
SHH-responsive 5-lipoxygenase, 15-lipoxygenase and COX-2 modulate Dectin-1-induced inflammatory cytokines.
Effect of 12/15-LOX on colorectal tumorigenesis in mouse models could be affected by tumor cell type (human or mouse), relative 12/15 LOX activity in tumor cells and stroma as well as the relative tumor 13-HODE and 12-HETE levels.
These observations provide novel insights on the role of XO in 12/15-LO-induced JamA tyrosine phosphorylation and TJ disruption leading to increased vascular permeability in response to HFD.
The crystal structure of a mammalian 12-lipoxygenase reveals a plausible substrate access channel for oxygen.
12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1.
EPR spectroscopy and electrospray mass spectroscopy reveal distinctive features of the iron site in leukocyte arachidonate 12-lipoxygenase.
The conserved residue Leu597 actually drives the regiospecific hydroperoxidation of linoleic acid catalyzed by 15-lipoxygenase enzyme.
The study presents an atomic-level study of catalytically competent binding modes for linoleic acid to rabbit 15-lipoxygenase and compare the results to our previous work on arachidonic acid.
Results indicate 15-lipoxygenase modified LDL as a new inducer for LOX-1 expression and as a new ligand for LOX-1.
15-Lipoxygenase metabolites contribute to age-related reduction in acetylcholine-induced hypotension in rabbits.
demonstrates 12-lipoxygenase and some 15-lipoxygenase enzyme activity
, arachidonate omega-6 lipoxygenase
, arachidonate 15-lipoxygenase
, arachidonate 12-lipoxygenase, leukocyte-type
, arachidonate 12-lipoxygenase, 12S-type
, Arachidonate 15-lipoxygenase
, erythroid cell-specific 15-lipoxygenase
, omega-6 lipoxygenase
, arachidonate lipoxygenase, epidermal