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anti-Mouse (Murine) CCR7 Anticorps:
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Human Monoclonal CCR7 Primary Antibody pour CyTOF, FACS - ABIN4899110
Lee, Fertig, Jin, Sukumar, Pandey, Popel: Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. dans Nature communications 2014
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Human Polyclonal CCR7 Primary Antibody pour ELISA, FACS - ABIN152135
Schweickart, Raport, Godiska, Byers, Eddy, Shows, Gray: Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. dans Genomics 1995
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Human Monoclonal CCR7 Primary Antibody pour FACS - ABIN4895614
Santra, Tomaras, Warrier, Nicely, Liao, Pollara, Liu, Alam, Zhang, Cocklin, Shen, Duffy, Xia, Schutte, Pemble Iv, Dennison, Li, Chao, Vidnovic, Evans, Klein, Kumar, Robinson, Landucci, Forthal et al.: Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques. ... dans PLoS pathogens 2015
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Human Monoclonal CCR7 Primary Antibody pour FACS - ABIN4895619
Kaur, Sanford, Garry, Lang, Klumpp, Watanabe, Bronson, Lifson, Rosati, Pavlakis, Felber, Knipe, Desrosiers: Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus. dans Virology 2006
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Human Monoclonal CCR7 Primary Antibody pour FACS - ABIN2689061
Kim, Pelus, White, Broxmeyer: Macrophage-inflammatory protein-3 beta/EBI1-ligand chemokine/CK beta-11, a CC chemokine, is a chemoattractant with a specificity for macrophage progenitors among myeloid progenitor cells. dans Journal of immunology (Baltimore, Md. : 1950) 1998
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Human Monoclonal CCR7 Primary Antibody pour FACS - ABIN2689059
Birkenbach, Josefsen, Yalamanchili, Lenoir, Kieff: Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. dans Journal of virology 1993
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Human Monoclonal CCR7 Primary Antibody pour FACS - ABIN2689060
Burgstahler, Kempkes, Steube, Lipp: Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2. dans Biochemical and biophysical research communications 1995
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Human Monoclonal CCR7 Primary Antibody pour FACS - ABIN4895610
Iyer, Gangadhara, Victor, Gomez, Basu, Hong, Labranche, Montefiori, Villinger, Moss, Amara: Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+ and CXCR5- CD4 T Cell Responses in Rhesus Macaques. dans Journal of immunology (Baltimore, Md. : 1950) 2015
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Mouse (Murine) Monoclonal CCR7 Primary Antibody pour CyTOF, FACS - ABIN4900691
Irino, Takeuchi, Matsuda, Saikawa, Kawakubo, Wada, Takahashi, Nakamura, Fukuda, Omori, Kitagawa: CC-Chemokine receptor CCR7: a key molecule for lymph node metastasis in esophageal squamous cell carcinoma. dans BMC cancer 2014
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Mouse (Murine) Monoclonal CCR7 Primary Antibody pour FACS, IP - ABIN1981861
Adachi, Osada, Nakamura, Tamada, Hamano: Unique T cells with unconventional cytokine profiles induced in the livers of mice during Schistosoma mansoni infection. dans PLoS ONE 2013
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Ccr7 functions during axis formation as a GPCR to inhibit beta-catenin, likely by promoting Ca(2+) transients throughout the blastula.
Absence of macrophage low-density lipoprotein receptor-related protein 1 unexpectedly accelerates atherosclerosis regression, enhances reverse cholesterol transport, and increases expression of the motility receptor CCR7, which drives macrophage egress from lesions.
CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms in vivo.
CCR7 and its ligands are also involved in HEV-mediated homing of blood-derived lymphocytes to BALT, highlighting the essential impact of the CCR7-CCL19/21 axis in different aspects of BALT biology.
A critical role for CCR7-inducible lnc-Dpf3 in coupling epigenetic.
Analyzing wild-type and CCR7 deficient (CCR7(-/-)) mice, this study observed a retarded glomerulogenesis during renal development and a significantly decreased mesangial cellularity in adult CCR7(-/-) mice, as a consequence of less mesangial cell proliferation between embryonic day E17.5 and week 5 postpartum.
CCR7-CCL21Ser interactions guide the migration of cDC progenitors to the thymus.
we show that a 24 amino acids long N-terminal signal sequence promotes efficient recruitment of CCR7 to endoplasmic reticulum (ER) exit sites, thereby controlling efficient ER to Golgi trafficking of CCR7 on its way to reach the plasma membrane.
We show that during T cell migration within lymphatic organs the contributions of the integrin LFA-1 and the chemokine receptor CCR7 are complementary rather than positioned in a linear pathway, as they are during leukocyte extravasation from the blood vasculature
results suggest that CCR7(+) mononuclear cells in the liver could regulate obesity-induced hepatic steatosis via induction of IL-10-expressing iNKT cells
A crucial role of CCR7 in neuroinflammation during the priming of autoimmune CD4(+) T cells but not in the CNS.
role in early development of functional deficits and subchondral bone changes in the DMM (destabilization of the medial meniscus) osteoarthritis model
Data report that CCR7 mediates CD11c+ cell migration from the CNS parenchyma to the meningeal lymphoid vessels and eventually to the deep cervical lymph nodes during neuroinflammation. In the absence of CCR7, dendritic cells are retained in the CNS and exacerbate neuroinflammation.
Conditions for optimal dendritic cells guidance are perfectly provided by the CCL21 gradients measured in vivo. Furthermore, CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6) is crucial for haptotactic but dispensable for chemotactic CCL21 gradient sensing in vitro and confirm those observations in vivo.
CCR7 deficiency results in apoptosis of Sirpa- dendritic cells, which is counterbalanced by expansion of immature Sirpa+ dendritic cells that efficiently induce Treg generation.
These data show that CCR7-CCL19/CCL21 axis facilitates retention CD4(+) T lymphocytes at the site of collateral artery remodeling, which is essential for effective arteriogenesis.
Results demonstrated that the deletion of CCR7 significantly decreases levels of activated Notch1, and provide evidence that crosstalk between CCR7 and Notch1 promotes stemness in mammary cancer cells ultimately potentiating mammary tumor progression.
CCR7 deficiency lead to accumulation of CD8+ adipose tissue leukocytes, which was further exacerbated by HFD feeding.
in the current study, we used interval mapping to validate a locus on Chr 15, named Ity8, linked to Salmonella resistance in AcB60 mice. Global gene expression analysis during infection identified AcB60-specific expression of genes involved in Ccr7 signaling, including downstream effector Mapk11 (mitogen-activated protein kinase 11), located within the Ity8 interval, and representing a potential positional candidate gene
Taken together, these data suggest that CCR7 biases memory CD8 T cells toward IL-7-dependent niches over IL-15-dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets.
Prominent mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clearance from the FRT(female reproductive tract) while reducing tissue-associated inflammation and pathology; increased numbers of lymphocytes within the FRT result in pathogen clearance with reduced immune-mediated pathology
Study found that CCR7 is recruited to the immunological synapse and acts as co-stimulatory molecule in human T cells. CCR7 associates with the zeta chain of the TCR and recruits and activates the tyrosine kinase ZAP70 upon chemokine triggering.
CCR7 can also potentially be a novel target for the therapy of pSS.
We demonstrated that functional CCR7 expression-which may enable CCR7-expressing human mast cells to migrate to T-cell-rich tertiary lymphoid structres having CCR7 ligands and to enhance mediator production-was strongly induced in human mast cells by IL-33
CCR7 promotes the progression of hepatocellular carcinoma, and its expression was associated with poor survival.
CCL19-mRFP and CCL21-mRFP are versatile and powerful tools to study CCR7 and ACKR4 functions.
Study indicates that chemokine receptor CCR7 (CCR7) homodimerization critically regulates CCR7 ligand-dependent cell migration and intracellular signaling in multiple cell types.
protein expression elevated in synovial tissue from osteoarthritis patients
Results suggest that chemokine (C-C motif) receptor 7 (CCR7)promotes triple-negative breast cancer (TNBC) metastasis and may serve as a target for breast cancer diagnosis and treatment.
High CCR7 expression is associated with urinary bladder cancer metastasis.
these data indicate CCL19/CCR7 contributes to proliferation and invasion of ESCs, which are conducive to the pathogenesis of endometriosis through activating PI3K/Akt pathway
The research findings demonstrate for the first time that the chemokines CCL19, CCL21 and CCR7 play important roles in bone destruction by increasing osteoclast migration and resorption activity, and that has been linked to rheumatoid arthritis pathogenesis.
CXCR4, CCR7, VEGF-C and VEGF-D expression might have synergistic effects on the lymph node metastasis in patients with cervical cancer.
the acute GvHD (aGvHD) patients received higher percentage of CD4+CCR7+ T-cells in donor T-cells, whereas chronic GvHD (cGvHD) patients were transplanted with higher percentages of CD8+CCR7+ T-cells. Functional experiments demonstrated that CCR7+ T-cells exhibited higher potential for activation than CCR7- T-cells did.
these results demonstrated that CCL21/CCR7 may activate EMT in lung cancer cells via the ERK1/2 signaling pathway.
CCL21/CCR7 interaction was shown to allow NK cell adhesion to endothelial cells (ECs) and its reduction by hypoxia.
Study shows that miR-1275 can positively regulate CCR7 expression in squamous cell carcinoma of head and neck (SCCHN) with different mechanisms.
Study provide evidence that CCR7 mediates EMT progress via AKT pathway, which indicates that CCR7 has a key role in breast cancer progression.
Report an increased percentage of peripheral CCR7 T cells accompanied by endothelial dysfunction in patients with ankylosing spondylitis.
The analysis of gene amplification and mRNA levels showed the expression of CCR7 in breast cancer correlated with better prognosis.
Fluorescent dye-labeled gammadelta T cells from afferent and efferent lymph lack CCR7 surface expression and display high levels of CD62L compared with CD4 T cells, which do express CCR7.
CCR7 transcripts were minimally expressed in ex vivo and proliferating WC1(+)gammadelta T cells, a unique cell population with proinflammatory characteristics
the pattern of expression of CCR7 in different populations of porcine lymphocytes appears to be similar to that of human, highlighting the value of the pig as a useful animal model for biomedical studies.
Pre-translntation of sertli cell CCR7 significantly suppresses lymphocyte proliferation and prolongs allogeneic skin graft survival.
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.
C-C chemokine receptor type 7
, CC chemokine receptor 7
, chemokine (C-C motif) receptor 7 a
, chemokine (C-C motif) receptor 7
, c-C chemokine receptor type 7-like
, C-C CKR-7
, EBV-induced G-protein coupled receptor 1
, MIP-3 beta receptor
, chemokine (C-C) receptor 7
, epstein-Barr virus-induced G-protein coupled receptor 1
, EBV-induced G protein-coupled receptor 1
, Epstein-Barr virus induced G-protein coupled receptor
, Epstein-Barr virus induced gene 1
, lymphocyte-specific G protein-coupled peptide receptor
, chemokine receptor 7