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Absence of macrophage low-density lipoprotein receptor-related protein 1 unexpectedly accelerates atherosclerosis regression, enhances reverse cholesterol transport, and increases expression of the motility receptor CCR7, which drives macrophage egress from lesions.
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CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms in vivo.
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CCR7 and its ligands are also involved in HEV-mediated homing of blood-derived lymphocytes to BALT, highlighting the essential impact of the CCR7-CCL19/21 axis in different aspects of BALT biology.
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A critical role for CCR7-inducible lnc-Dpf3 in coupling epigenetic.
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Analyzing wild-type and CCR7 deficient (CCR7(-/-)) mice, this study observed a retarded glomerulogenesis during renal development and a significantly decreased mesangial cellularity in adult CCR7(-/-) mice, as a consequence of less mesangial cell proliferation between embryonic day E17.5 and week 5 postpartum.
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CCR7-CCL21Ser interactions guide the migration of cDC progenitors to the thymus.
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we show that a 24 amino acids long N-terminal signal sequence promotes efficient recruitment of CCR7 to endoplasmic reticulum (ER) exit sites, thereby controlling efficient ER to Golgi trafficking of CCR7 on its way to reach the plasma membrane.
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We show that during T cell migration within lymphatic organs the contributions of the integrin LFA-1 and the chemokine receptor CCR7 are complementary rather than positioned in a linear pathway, as they are during leukocyte extravasation from the blood vasculature
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results suggest that CCR7(+) mononuclear cells in the liver could regulate obesity-induced hepatic steatosis via induction of IL-10-expressing iNKT cells
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A crucial role of CCR7 in neuroinflammation during the priming of autoimmune CD4(+) T cells but not in the CNS.
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role in early development of functional deficits and subchondral bone changes in the DMM (destabilization of the medial meniscus) osteoarthritis model
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Data report that CCR7 mediates CD11c+ cell migration from the CNS parenchyma to the meningeal lymphoid vessels and eventually to the deep cervical lymph nodes during neuroinflammation. In the absence of CCR7, dendritic cells are retained in the CNS and exacerbate neuroinflammation.
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Conditions for optimal dendritic cells guidance are perfectly provided by the CCL21 gradients measured in vivo. Furthermore, CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6) is crucial for haptotactic but dispensable for chemotactic CCL21 gradient sensing in vitro and confirm those observations in vivo.
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CCR7 deficiency results in apoptosis of Sirpa- dendritic cells, which is counterbalanced by expansion of immature Sirpa+ dendritic cells that efficiently induce Treg generation.
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These data show that CCR7-CCL19/CCL21 axis facilitates retention CD4(+) T lymphocytes at the site of collateral artery remodeling, which is essential for effective arteriogenesis.
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Results demonstrated that the deletion of CCR7 significantly decreases levels of activated Notch1, and provide evidence that crosstalk between CCR7 and Notch1 promotes stemness in mammary cancer cells ultimately potentiating mammary tumor progression.
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CCR7 deficiency lead to accumulation of CD8+ adipose tissue leukocytes, which was further exacerbated by HFD feeding.
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in the current study, we used interval mapping to validate a locus on Chr 15, named Ity8, linked to Salmonella resistance in AcB60 mice. Global gene expression analysis during infection identified AcB60-specific expression of genes involved in Ccr7 signaling, including downstream effector Mapk11 (mitogen-activated protein kinase 11), located within the Ity8 interval, and representing a potential positional candidate gene
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Taken together, these data suggest that CCR7 biases memory CD8 T cells toward IL-7-dependent niches over IL-15-dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets.
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Prominent mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clearance from the FRT(female reproductive tract) while reducing tissue-associated inflammation and pathology; increased numbers of lymphocytes within the FRT result in pathogen clearance with reduced immune-mediated pathology