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Human CD46 Protein expressed in Human Cells - ABIN2215294
Douradinha, McBurney, Soares de Melo, Smith, Krishna, Barratt-Boyes, Evans, Nascimento, Marques: C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells. dans Virus research 2014
Show all 2 Pubmed References
CD46 delivers co-stimulatory signals for optimal CD8(+) T cell activity by augmenting nutrient-influx and fatty acid synthesis.
Only type-I interferon restricts viral replication of attenuated Measles virus (MV) Schwarz strain in mice, independently of the presence of hCD46 receptor.
CD46 levels were positive in 3.3% (n = 3) and negative in 96.7% (n = 90). Conclusion This study does not support the theory of measles virus as the cause of otosclerosis.
Findings demonstrate that CD46 is a key inhibitor of complement activation whose downregulation may be involved in the pathogenesis of bullous pemphigoid.
these data suggest a possible mechanism underlying the regulatory function of CD46 on T cells.
study demonstratede that MMP-9-mediated shedding of CD46 is an integral part of autocrine Th1 regulation and that this pathway is dysregulated in T cells from patients with systemic lupus erythematosus
the cell surface expression level of CD46 was markedly higher in patient myeloma cells with 1q gain than in those with normal 1q copy number.
Our findings reveal a novel role of CD46 in accelerating inflammatory responses upon meningococcal infection or LPS stimulation by regulating the functional polarization and survival of macrophages.
study reveals common CD46 and IFI44L SNPs associated with measles-specific humoral immunity, and highlights the importance of alternative splicing/virus cellular receptor isoform usage as a mechanism explaining inter-individual variation in immune response after live measles vaccine
study showed no genotype differences in CD46 IVS1-1724 C>G Single nucleotide polymorphis (SNP) between Recurrent Spontaneous Abortion and fertile women
Isoforms of CD46 impact on HHV-6B infection and thereby in part explain the distinct tropism of HHV-6AGS and HHV-6BPL1.
This study suggests that the promoter polymorphism (rs2796267, -496 A/G) CD46 gene may be related to susceptibility of acute renal allograft rejection in Korean kidney transplantation recipients.
provides insight into CD46 alternative splicing regulation with implications for its function in the immune system and for genetic disease
CD46 controls both Th1 activation and regulation via a miR-150-dependent mechanism.
Data show that CD28 antigen costimulation modulates CD46 antigen surface expression on activated T cells.
This review summarizes our current knowledge of disease-associated mutations in this complement inhibitor(CD46).
It was not discover any association between A304V or other CD46 SNPs and preeclampsia.
gene deficiency results in defective Th1 cell induction due to failure in metabolic reprogramming
Each mutant C3b bound MCP at reduced affinity, providing a molecular basis for its reduced cofactor activity in atypical hemolytic uremic syndrome.
The mutations in the regulators CFH, CFI and MCP involve loss-of-function, whereas those for C3 involve gain-of-function.
Changes in CD46 expression may lead to changes in VEGF and play a pathologic role in the development of age-related macular degeneration.
Our findings provide evidence for expression of CD46 in the mouse eye and a role for CD46 in protection against laser-induced choroidal neovascularization
This fusion is mediated by the interaction between viral glycoproteins expressed on the membrane of the infected cells and CD46 on the glial targets, and is also observed using cells expressing recombinant MV glycoproteins.
CD46 isoforms function as receptors for human herpesvirus 6 and measles virus
Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm and increased male fertility
CD46 has a role as a receptor for fusion and entry of human herpesvirus 6 into target cells
The results obtained in this study showed that both porcine CD46 and heparan sulfates play a major role in the initial steps of classical swine fever virus infection.
study found that sCD46 is not detectable in fetal and neonatal sera and that its plasma concentration increases progressively up to adulthood; also detected high- and low-sCD46 performers and show that this phenotype does not depend of environmen.
Study shows the existence of 10 distinct allelic versions of the CCP1 module of CD46; ectopic expression of the 10 bovine CD46 isoforms rendered the PK15 cells permissive to bovine viral diarrhea virus.
localization of CD46 on bovine sperm membrane
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
CD46 antigen, complement regulatory protein
, antigen identified by monoclonal antibody TRA-2-10
, complement membrane cofactor protein
, measles virus receptor
, membrane cofactor protein
, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
, trophoblast leucocyte common antigen
, trophoblast leukocyte common antigen
, trophoblast-lymphocyte cross-reactive antigen
, brain microvascular membrane cofactor
, membrane cofactor protein(GMP1-full)