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Mammalian Monoclonal DLG1 Primary Antibody pour ISt, IHC - ABIN1304943
Jafari, Esmaili, Toufan, Aghamollaei: Bilingual proficiency and cognitive reserve in Persian-English bilingual older adults. dans Aging clinical and experimental research 2015
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Human Monoclonal DLG1 Primary Antibody pour ICC, IF - ABIN4305323
Cui, Hayashi, Sun, Belmares, Cobey, Phan, Schweizer, Salter, Wang, Tasker, Garman, Rabinowitz, Lu, Tymianski: PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
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Human Monoclonal DLG1 Primary Antibody pour IF, IP - ABIN968224
Adey, Huang, Ormonde, Baumgard, Pero, Byreddy, Tavtigian, Bartel: Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding. dans Cancer research 2000
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Human Monoclonal DLG1 Primary Antibody pour IF, IP - ABIN968225
Caruana, Bernstein: Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene. dans Molecular and cellular biology 2001
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Human Polyclonal DLG1 Primary Antibody pour ELISA, WB - ABIN451674
Mahoney, Sammut, Xavier, Cunningham, Go, Brim, Stappenbeck, Miner, Swat: Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. dans Proceedings of the National Academy of Sciences of the United States of America 2006
Human Polyclonal DLG1 Primary Antibody pour ICC, IF - ABIN269417
Gardner, Naren, Bahouth et al.: Assembly of an SAP97-AKAP79-cAMP-dependent protein kinase scaffold at the type 1 PSD-95/DLG/ZO1 motif of the human beta(1)-adrenergic receptor generates a receptosome involved in receptor recycling ... dans The Journal of biological chemistry 2007
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Rat (Rattus) Polyclonal DLG1 Primary Antibody pour WB - ABIN1742275
Smalla, Sahin, Putzke, Tischmeyer, Gundelfinger, Kreutz: Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis. dans Neurochemical research 2009
Adrenergic modulation of Kv1.1 (Montrer KCNA2 Anticorps) was mediated by the signaling scaffold SAP97, which, through direct protein-protein interactions, escorts beta2 signaling to remove Kv1.1 (Montrer KCNA2 Anticorps) from the dendrite surface. This process promoted spike timing-dependent long-term synaptic potentiation at mouse hippocampal excitatory synapses.
that Pten, through the Dlg1-binding ability of its PDZ (Montrer INADL Anticorps)-binding domain , accumulates phosphorylated Eg5 (Montrer KIF11 Anticorps) at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes
Kif13b (Montrer KIF13B Anticorps) also negatively regulates Dlg1 stability in oligodendrocytes, in which Dlg1, in contrast to Schwann cells, enhances AKT (Montrer AKT1 Anticorps) activation and promotes myelination
Dlg1 regulates p38 (Montrer CRK Anticorps)-dependent proinflammatory cytokine production.
phenotypes of Dlg1-/- mice involving cellular disorganization and insufficient tissue elongation strongly suggest a defect in the convergent extension movements
Loss of Dlg1 confers strong predisposition to the development of pediatric B-ALL in a murine model.
data indicate that the surface expression and function of EAAT2b can be rapidly modulated through the disruption of its interaction with DLG1 by CaMKII (Montrer CAMK2G Anticorps) activation.
Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor receptor signaling.
lack of the Dlg1 gene induces a decrease in apoptotic epithelial cell death and the persistence of the common nephric duct, which result in a dysfunctional vesicoureteral junction and cause megaureter or hydronephrosis through vesicoureteral reflux
DLG1 influences distal ureter maturation via a non-epithelial cell autonomous mechanism involving reduced retinoic acid signaling, Ret (Montrer RET Anticorps) expression, and apoptosis.
These data support diverging presynaptic and postsynaptic roles of SAP97 N-terminal isoforms in synapse maturation and plasticity
Single nucleotide polymorphism in DLG1 gene is associated with schizophrenia.
Low expression of DLG1 is associated with Crohn's disease.
BAIAP2 (Montrer BAIAP2 Anticorps) is a candidate gene for mediating dendritic spine density abnormalities in schizophrenia. Data suggest that altered DNA methylation (Montrer HELLS Anticorps) in schizophrenia may be a mechanism for schizophrenia-related dendritic spine density reductions.
Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt/beta-catenin signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta phosphorylation.
Results suggest that discs large (Montrer DLG4 Anticorps) tumour suppressor (DLG1) expression may have an important role in the progression of early dysplastic cervical lesions, giving prognostic information.
Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia was identified.
Human papillomavirus oncoproteins E6 and E7 induce the loss of DLG1 from the cell borders and an increase in the level of DLG1 protein, reflecting the pattern observed in cervical lesions.
The study provides new evidence for understanding the transcriptional regulation of DLG1 and the changes in DLG1 expression during different biological processes.
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.
discs, large homolog 1 (Drosophila)
, synapse-associated protein 97
, disks large homolog 1
, Drosophila discs-large tumor suppressor homologue (synapse associated protein)
, embryo-dlg/synapse-associated protein 97
, presynaptic protein SAP97