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General |
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Antigène | Discs, Large Homolog 1 (Drosophila) (DLG1) Anticorps |
Reactivité | Humain, Souris, Rat (Rattus) Alternatives |
Hôte | Lapin Alternatives |
Clonalité | |
Conjugué | Inconjugué Alternatives |
Application |
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Alternatives
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Fournisseur | Connectez-vous pour afficher |
Détail du produitDétail du antigène Information d'application Stockage Images |
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Purification | Purified by Protein A. |
Immunogène | KLH conjugated synthetic peptide derived from human SAP97 |
Isotype | IgG |
Détail du antigèneDétail du produit Information d'application Stockage Images Haut de la page |
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Antigène | |
Autre désignation | Sap97 (DLG1 Antibody Extrait) |
Sujet |
The discs large (dlg) tumor suppressor gene was first identified in Drosophila through genetic analysis of germline mutations. Several mammalian homologs were subsequently identified and categorized into a protein family designated MAGUK (membrane-associated guanylate kinase homolog). The mammalian homolog of dlg, SAP 97, is also known as hdlg-1 (human) and NE-dlg (neuronal and endocrine). The rat synaptic protein SAP 90 (also designated PSD-95) also shares homology with these proteins. MAGUKs are localized at the membrane-cytoskeleton interface and contain several distinct domains which suggest a role for these proteins in intracellular signal transduction. Interaction of hdlg-1 and NE-dlg with the tumor suppresor protein APC suggest that MAGUK proteins may also play a role in regulation of growth. Synonyms: Discs large homolog 1, Disks large homolog 1, DLG 1, DLG1, DLG1_HUMAN, DLGH 1, DLGH1, HDLG, Presynaptic protein SAP97, SAP 97, SAP-97, SAP97, Synapse associated protein 97, Synapse-associated protein 97 |
ID gène | 1739 |
Pathways | Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response |
Information d'applicationDétail du produit Détail du antigène Stockage Images Haut de la page |
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Indications d'application |
IHC-P 1:100-500 IF(IHC-P) 1:50-200 |
Restrictions | For Research Use only |
StockageDétail du produit Détail du antigène Information d'application Images Haut de la page |
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Format | Liquid |
Concentration | 1 μg/μL |
Buffer | Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide. |
Agent conservateur | Sodium azide |
Précaution d'utilisation | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. |
Stock | -20 °C |
Stockage commentaire | Store at -20°C |
Date de péremption | 12 months |