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anti-Human FHOD3 Anticorps:
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Human Polyclonal FHOD3 Primary Antibody pour IHC, IHC (p) - ABIN4311640
Wooten, Hebl, Wolf, Greytak, Orr, Draper, Calvino, Kapur, Maron, Kullo, Ommen, Bos, Ackerman, Huggins: Formin homology 2 domain containing 3 variants associated with hypertrophic cardiomyopathy. dans Circulation. Cardiovascular genetics 2013
FHOD3 is a novel disease gene in hypertrophic cardiomyopathy, accounting for approximately 2% of cases.
These results indicate that RBM20 and PTBP1 play a role in the actin filament functional organization mediated by FHOD3 isoforms and suggest their possible involvement in heart diseases.
FHOD3 played a role in glioma linear migration.
Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo.
DCM-associated FHOD3 variant may cause DCM by interfering with actin filament assembly.
FHOD variants is with hypertrophic cardiomyopathy.
C-terminal phosphorylation by ROCK1 is sufficient for FHOD3 activation as evidenced by an increase in F-actin in HeLa cells.
Single nucleotide polymorphism in FHOD3 gene is associated with acute lymphoblastic leukemia.
actin dynamics regulated by Fhod3 are critical for sarcomere organization in striated muscle cells.
Perinatal KO of Fhod3 in the heart caused juvenile lethality at around day 10 after birth with enlarged hearts composed of severely impaired myofibrils, indicating that Fhod3 is crucial for postnatal heart development.
these findings suggest the possibility that Fhod3 contributes to the pathogenesis of cMyBP-C-related cardiomyopathy and that Fhod3 is critically involved in cMyBP-C-mediated regulation of cardiac function via direct interaction.
Up regulation of FHOD3 play a crucial role in the pathogenesis of cardiac hypertrophy in mouse model.
during embryonic cardiogenesis, Fhod3 functions as the essential reorganizer of actin filaments at the central region of maturating sarcomeres via the actin-binding activity of the FH2 domain
Analysis of casein kinase 2 alpha knockout mice showed that phosphorylation by casein kinase 2 is also required for proper targeting of muscle Fhod3 to the myofibrils in embryonic cardiomyocytes in situ.
embryonic heart of mice specifically expresses the Fhod3 mRNA isoform harboring the three alternative exons
Proteins that contain formin (FMN1\; MIM 136535) homology (FH) domains, such as FHOD3, play a role in regulation of the actin cytoskeleton (Kanaya et al., 2005
FH1/FH2 domain-containing protein 3
, formin homology 2 domain containing 3
, formin homolog overexpressed in spleen 2
, formin-family protein FHOS2
, formin homology 2 domain containing 3-like