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enpp1 can exert its function in tissues that are remote from its site of expression.
ENPP1 gene variants may have a potential impact on the occurrence of T2 diabetes mellitus in Northern Iranians.
ENPP1 K121Q polymorphism is associated with type 2 diabetes mellitus in Ukrainian population. In carriers of the minor Q-allele the risk of T2DM is 1.4x higher than in homozygotes in the main K-allele. The risk increases in patients with BMI >/= 25 kg/m2
this study shows that ENPP1 is biomarker candidate for endometriosis
ENPP1 rs997509 polymorphism is associated with type 2 diabetes mellitus development in Ukrainian population.
This meta-analysis revealed that the K121Q (rs1044498 C > A) in the ENPP1 gene is a risk factor for Coronary Heart Disease.
these results show that ENPP1 polymorphism influences lower anterior face height, the distance from the upper lip to the nasal floor, and lip shape
PC-1 (Montrer PCSK1 Protéines) works in conjunction with E3 ligase CHIP to regulate androgen receptor (Montrer AR Protéines) stability and activity.
Single nucleotide polymorphism in ENPP1 gene is associated with Gender differences in type 2 diabetes.
Single nucleotide polymorphism in ENPP1 gene is associated with developing of bone disorders in type 2 diabetes.
ENPP1 defines a subset of human B cells that differs significantly from mouse peritoneal B-1a and proposed human B-1 cells.
Evidence of a causative link between ENPP1 and alterations in insulin (Montrer INS Protéines) signaling, glucose uptake, and lipid metabolism in subcutaneous abdominal Adipose tissue of gestational diabetes, which may mediate insulin (Montrer INS Protéines) resistance and hyperglycemia in Gestational diabetes.
Results show that urine pyrophosphate (PPI) levels are increased in Npt2a-/- mice when compared to WT, possibly to protect from renal mineralization in the setting of hyperphosphaturia. However, the presence of two hypomorphic Enpp1asj/asj alleles decreases urine PPi and worsens renal calcium phosphate deposit formation in Npt2a-/- mice.
identified ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) as the first known mammalian enzyme lacking a NUDIX domain to generate pR from ADP-ribose on modified proteins in vitro
Vitamin D3 regulates Enpp1 expression, which presumably, in the context of adequate tissue non-specific alkaline phosphatase activity, provides phosphate to stimulate mineralisation.
ENPP1-Fc fusion protein prevents the mortality, vascular calcifications and sequela of disease in mouse models of generalized arterial calcification of infancy.
Expression of NPP1 and 5'-nucleotidase (Montrer ACPP Protéines) by valve interstitial cells promotes the mineralization of the aortic valve through A2aR (Montrer ADORA2A Protéines) and a cAMP/PKA/CREB (Montrer CREB1 Protéines) pathway.
Increased NPP1 expression and activity might contribute to the decreased mineralisation observed when osteoblasts are exposed to acid conditions.
NPP1 has a role in obesity and diabetes in a mouse model
we have characterized the phenotypic and histopathologic features of this spontaneous mutant mouse, designated as asj (Montrer ARSJ Protéines)-2J, and we have identified a large deletion/insertion mutation in the Enpp1 gene
these data highlight the key role of NPP1 in regulating calcification of both soft and skeletal tissues.
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.
ectonucleotide pyrophosphatase/phosphodiesterase 1
, ectonucleotide pyrophosphatase/phosphodiesterase family member 1
, ectonucleotidase enpp1
, E-NPP 1
, Ly-41 antigen
, alkaline phosphodiesterase 1
, membrane component chromosome 6 surface marker 1
, membrane component, chromosome 6, surface marker 1
, phosphodiesterase I/nucleotide pyrophosphatase 1
, plasma-cell membrane glycoprotein 1
, plasma-cell membrane glycoprotein PC-1
, 1 ectonucleotide pyrophosphatase/phosphodiesterase 1
, lymphocyte antigen 41
, phosphodiesterase I/nucleotide pyrophosphatase 1; 1 ectonucleotide pyrophosphatase/phosphodiesterase 1
, tiptoe walking