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anti-Human ARHGAP24 Anticorps:
anti-Mouse (Murine) ARHGAP24 Anticorps:
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Human Polyclonal ARHGAP24 Primary Antibody pour ICC, IF - ABIN4281511
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. dans Nature methods 2013
Results showed that ARHGAP24 expression was downregulated in lung cancer tissues and cell lines.
ARHGAP24 can suppress the development of MDA-MB-231 cells via the STAT3 signaling pathway, and sorafenib inhibits cell viability, migration, invasion, and STAT3 activation in MDA-MB-231 cells through ARHGAP24.
MicroRNA-590-5p regulates cell viability, apoptosis, migration and invasion of renal cell carcinoma cell lines through targeting ARHGAP24
ARHGAP24 plays a unique role in renal cell carcinoma progression as a tumor repressor.
this study clearly provided evidence that FilGAP, as well as IDH1 status, may be useful for predicting the behavior of astrocytomas. In addition, the FilGAP/Rac1 axis may serve as an important regulator of tumor progression in GBMs, probably through alteration of cell morphology.
ARHGAP24 may regulate pseudopod formation downstream of activated ARF6 in MDA-MB-231 human breast carcinoma cells.
Study identified FilGAP as a negative regulator of lymphocyte polarization and migration and shows that FilGAP may suppress lamellae formation at the front of migrating lymphocyte.
Src family tyrosine kinase signaling may regulate FilGAP through association with RBM10
FilGAP may contribute to change in cell motility of B-lymphocytes and in addition, its expression appears to be useful for predicting the behavior of B-cell lymphoma, in particular follicular lymphoma.
study suggests that Arf6 and phosphorylation of FilGAP may regulate FilGAP, and phosphorylation of Ser-402 may play a role in the regulation of cell spreading on fibronectin
Polymorphism rs346473 in the ARHGAP24 gene might be a part of the genetic variants.
FilGAP may function as a mediator of the regulation of Rac by Arf6.
Data indicate that phosphorylation of FilGAP by ROCK appears to promote amoeboid morphology.
Consistent with structural predictions, strain increases beta-integrin binding to FLNA, whereas it causes FilGAP to dissociate from FLNA, providing a direct and specific molecular basis for cellular mechanotransduction
sequencing of the ARHGAP24 gene in patients with focal segmental glomerulosclerosis (FSGS) identified a mutation that impaired its Rac1-GAP activity and was associated with disease in a family with FSGS
p73, a vascular cell-specific GTPase-activating protein, is an important modulator of angiogenesis
propose that RC-GAP72 affects cellular morphology by targeting activated Cdc42 and Rac1 GTPases to specific subcellular sites, triggering local morphological changes
FilGAP plays a role in protecting cells against force-induced apoptosis.
Point mutagenesis revealed that disruption of the FLNa-FilGAP interface perturbs cell spreading. FilGAP does not bind FLNa homologs FLNb or FLNc establishing the importance of this interaction to the human FLNa mutations
Increased levels of active Rac1 and Cdc42 were measured in Arhgap24 knockdown experiments, which influenced podocyte cell shape and membrane dynamics.
ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA\; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004
RAC1- and CDC42-specific GTPase-activating protein of 72 kDa
, filamin-A-associated RhoGAP
, rho GTPase-activating protein 24
, rho-type GTPase-activating protein 24
, rhoGAP of 73 kDa
, sarcoma antigen NY-SAR-88
, Down-regulated in nephrectomized rat kidney 2