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anti-Human ROBO2 Anticorps:
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Human Polyclonal ROBO2 Primary Antibody pour CyTOF, FACS - ABIN4900196
Geutskens, Hordijk, van Hennik: The chemorepellent Slit3 promotes monocyte migration. dans Journal of immunology (Baltimore, Md. : 1950) 2010
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Human Monoclonal ROBO2 Primary Antibody pour CyTOF, FACS - ABIN4900566
Guijarro-Muñoz, Cuesta, Alvarez-Cienfuegos, Geng, Alvarez-Vallina, Sanz: The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis. dans Experimental cell research 2012
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Human Polyclonal ROBO2 Primary Antibody pour ICC, IF - ABIN4350856
Sanz-Pamplona, Berenguer, Cordero, Molleví, Crous-Bou, Sole, Paré-Brunet, Guino, Salazar, Santos, de Oca, Sanjuan, Rodriguez-Moranta, Moreno: Aberrant gene expression in mucosa adjacent to tumor reveals a molecular crosstalk in colon cancer. dans Molecular cancer 2014
determined the crystal structure of the tandem Ig4-5 domains (D4-5) of human Robo2 and found that a hydrophobic surface on D4 mediates close homotypic contacts with a reciprocal D4
human placental multipotent mesenchymal stromal cell express Slit2 and both Robo1 and Robo4 are present in human umbilical vein endothelial cells.
ROBO2 variants were not found to be associated with nonsyndromic vesicoureteral reflux with or without renal hypoplasia/dysplasia, providing further evidence for genetic heterogeneity
ROBO2 and RASSF2A gene methylations may be related to gastric tumorigenesis, and ROBO2 gene methylation is associated with sporadic gastric cancer.
Overexpression of ROBO2 induces its tumor suppressive effects in Breast cancer
ROBO2 somatic mutation is associated with myelodysplastic syndrome progression. Overexpression of ROBO2 produces anti-proliferative and pro-apoptotic effects in leukemia cells. This effect was lost in ROBO mutants and ROBO-SLIT2 signaling is impaired.
Common variation near ROBO2 is associated with expressive vocabulary in infancy.
Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract
Down-regulation of ROBO2 expression is associated with prostate cancers.
Frameshift mutations of ROBO1 and ROBO2 genes and alteration of ROBO2 expression in gastric and colorectal cancers suggest that both genes might play roles in the pathogenesis of both cancers.
The finding that a polymorphism associated with the ROBO2 gene, which is involved in neurodevelopment, confers risk for the common emotionally reactive, impulsive aspects of conduct disorder, independent of concurrent risk for psychopathy.
Results not completely rule out that some ROBO2 variants may be the sole cause of vesicoureteric reflux, but it is clear from the overall frequency that most of them cannot be.
data suggests the importance of abrogation of SLIT2-ROBO1 and SLIT2-ROBO2 interactions in the initiation and progression of CACX and also for early diagnosis and prognosis of the disease
two differentially expressed isoforms were isolated and identified. Exons 1 and 2 of human ROBO2a lie in an inherently unstable DNA segment at human chromosome 3p12.3.
Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.
a relatively high frequency of ROBO2 variants (5.1%) was found in familial vesicoureteral reflux
mRNA expression of ROBO2 in lymphocytes was significantly reduced in the autistic group
gene variants in ROBO2 are rare causes of VUR in humans. Our results provide further evidence for the genetic heterogeneity of this disorder
repulsive Slit-Robo2-Ena signaling exerts an extrusive force downstream of JNK to eliminate scrib cells from epithelia by disrupting E-cadherin.
The authors describe a distinct mechanism to inhibit Robo1 repulsion and promote midline crossing, in which Roundabout2 (Robo2) binds to and prevents Robo1 signaling.
a Robo2-mediated mechanism, independent of signaling, is essential to limiting Slit distribution and which might be relevant to the regulation of Slit-mediated short-range signaling in additional systems
Data identify Robo2 and Robo3 as key effectors of Hb9 in regulating nervous system development.
Data show that Robo and Robo2 promote midline repulsion, while Robo2 and Robo3 specify the position of longitudinal axon pathways.
Study found that lateral positioning does not rely on structural differences between the Robo1 and Robo2 receptors-neither in their ectodomain nor cytoplasmic domains instead expression differences alone can account for lateral pathway selection.
At the CNS midline, Slit functions as a repellent for tracheal branches and this function is mediated primarily by Robo. Robo2 is necessary for the tracheal response to the attractive Slit signal and its function is antagonized by Robo.
robo, robo2, and robo3 play a role in the guidance of sensory axons in the Drosophila embryo by both slit-dependent and slit-independent mechanisms.
axon guidance molecules roundabout2 and roundabout3 (robo2/3) are necessary for serotonergic neuron differentiation
midline-secreted Slit activates Robo/Robo2 signalling to control the migration of the vmd1a sensory precursor cells
Trans signaling by Robo2 contributes to the normal positioning of the thoracic Chordotonal (Cho) stretch receptor organs.
Slit and Robo-family proteins act to maintain the distinct cellular composition of the developing lamina and the lobula cortex
robo2 is required for heart assembly
Results describe the role of Slit and its transmembrane receptors Roundabout (Robo) and Roundabout2 (Robo2) during morphogenesis of the Drosophila heart tube, a process analogous to early heart formation in vertebrates.
Genetic analysis showed that Caspase-3, Caspase-9, and p38 MAPK interacted with Slit1a-Robo2 signaling.
The N-terminal domain unique to Robo3a.1 mediates blockade of Robo2 repulsive activity.
Robo2-Slit and Dcc-Netrin1 coordinate the axonal projection choices of neurons developing in the forebrain.
These results reveal that subtype-specific activity of Robo2 regulates subcircuit morphogenesis in the trigeminal sensory system.
Robo2_tv2 is expressed differentially in most non-neuronal tissues of adult zebrafish whereas robo2_tv1 expression to a great extent is restricted to the brain and eye.
Increased arborization in robo2 mutants was phenocopied by dominant-negative Robo2 expressed in single retinal ganglion cells and rescued by full-length Robo2, indicating that Robo2 acts cell-autonomously.
Robo2 acted initially to split the tract of the postoptic commissure into discrete fascicles upon entering a broad domain of Slit1a expression in the ventrocaudal diencephalon.
Study concludes that Robo1 and Robo2 have redundant functions to guide multiple aspects of the complex cell migration of the facial nucleus, as well as regulating axon trajectories and suppressing formation of ectopic axons.
Robo2 acts non-autonomously as a stroma suppressor gene by restraining myofibroblast activation and T-cell infiltration.
High robo-2 expression is associated with hepatic fibrosis.
Here the authors find that the developmental axon guidance receptor Roundabout 2 (Robo2) is critical for the maintenance of inhibitory synapses in the adult ventral tegmental area (VTA), a brain region important for the production of the neurotransmitter dopamine.
Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling. Results demonstrate that a migratory subset of motor neurons respond to floor plate-derived Slit repulsion to properly control the timing of contralateral migration.
While Slit1 and Robo2 are only expressed in peripheral axons and their cell bodies, Slit2, Slit3 and Robo1 are also expressed in satellite cells of the dorsal root ganglion, Schwann cells and fibroblasts of peripheral nerves.
Robo1/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice
Roundabout receptor (Robo) genes are expressed in pulmonary neuroendocrine cells (PNECs), a rare, innervated epithelial population. Robo inactivation in mouse lung results in an inability of PNECs to cluster into sensory organoids and triggers increased neuropeptide production upon exposure to air.
Cardiac defects in mutants for Robo or Slit range from membranous ventricular septum defects to bicuspid aortic valves.
These observations from mutant Slit and Robo mice give great support for Slit/Robo role in neural crest cell migration during Enteric Nervous System development.
Loss of Robo2 resulted in a failure of the normal separation of the mesenchyme from the Wolffian duct/ureteric epithelium.
Slit2 signaling through Robo1 and Robo2 has a role in retinal neovascularization
Mycbp2 and Robo2 were found to cooperate within a genetic network that has profound effects on axon guidance
Slit/Robo signaling imposes a restriction force on spiral ganglia neurons to ensure their precise positioning for correct spiral ganglia-cochlear hair cells innervations.
Report role of Robo2 in development of the caval veins and pericardium.
Inactivation of Robo 2 leads to mispositioning of the stomach in the thoracic instead of the abdominal cavity, which likely contributes to poor lung inflation and lethality at birth, reminiscent of congenital diaphragmatic hernia.
Robo2 signaling acts as a negative regulator on nephrin to influence podocyte foot process architecture.
Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes.
Slits and Robo-2 are required for the formation of an accurate glomerular map in the ventral region of the olfactory bulb .
This gene belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. The encoded protein is a receptor for SLIT2, molecules known to function in axon guidance and cell migration. Defects in this gene are the cause of vesicoureteral reflux type 2. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
roundabout homolog 2
, roundabout 2 precursor
, Roundabout2 protein
, roundabout, axon guidance receptor, homolog 2 (Drosophila)
, roundabout, axon guidance receptor, homolog 2
, roundabout homolog 2-like
, SGP cluster fusion defects 4
, roundabout 2
, Robo 2
, LOW QUALITY PROTEIN: roundabout homolog 2