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Slit3 (and slit-2 (Montrer SLIT2 Protéines)) coordinate neuron axonal pathfinding within the embryonic axon tracts along with Robo2 (Montrer ROBO2 Protéines) and Dcc (Montrer DCC Protéines)-Netrin1.
Data show that Hedgehog (Montrer SHH Protéines) signaling is required for commissure formation, glial bridge formation, and the restricted expression of the guidance molecules slit1a, slit2 (Montrer SLIT2 Protéines), slit3 and sema3d (Montrer SEMA3D Protéines).
Overexpression of Slit3 (Montrer SLIT1 Protéines) induces its tumor suppressive effects in Breast cancer.
Results show that silencing of Slit3 (Montrer SLIT1 Protéines) promoted proliferation, migration and invasion of A549 cells and induced epithelial-mesenchymal transition suggesting that Slit3 (Montrer SLIT1 Protéines) functions as a tumor suppressor in lung carcinoma.
Estrogen-dependent expression of SLIT3 (Montrer SLIT1 Protéines) may play a key role in regulating nerve-vessel interactions within the complex microenvironment of endometriosis lesions.
SLIT3 (Montrer SLIT1 Protéines) is increased with labour, and both amnion and myometrial studies describe a pro-inflammatory effect of SLIT3 (Montrer SLIT1 Protéines) in these tissues.
High SLIT3 (Montrer SLIT1 Protéines) expression is associated with high-grade gliomas.
SLIT3 (Montrer SLIT1 Protéines)-ROBO4 (Montrer ROBO4 Protéines) activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo.
results implicate the involvement of miR (Montrer MLXIP Protéines)-218-2 and its host gene SLIT3 (Montrer SLIT1 Protéines) in thyroid cancer cell invasion, migration, and proliferation
Slit3 treatment increased the in vivo homing efficiency of CD34 HSPCs to the BM in NOD/SCID mice, whereas Slit3-exposed HSPC migration in vitro was inhibited. Results support a role for Slit3 in human HSPC migration in vitro and homing in vivo.
three major members (Slit2/3 and Robo1 (Montrer ROBO1 Protéines)) of Slit/Robo family are widely expressed in the human normal and malignant ovarian tissues; but Slit/Robo signaling may not play an important role in regulating human ovarian cancer cell proliferation and migration
SLIT3 (Montrer SLIT1 Protéines) duplication on 5q35.1 predisposes to major depressive disorder
While Slit1 (Montrer SLIT1 Protéines) and Robo2 (Montrer ROBO2 Protéines) are only expressed in peripheral axons and their cell bodies, Slit2 (Montrer SLIT2 Protéines), Slit3 and Robo1 (Montrer ROBO1 Protéines) are also expressed in satellite cells of the dorsal root ganglion, Schwann cells and fibroblasts of peripheral nerves.
Heparan sulfate-deficient mouse endothelial cells was used to determine the co-reception function of heparan sulfate in Slit3-induced endothelial cell migration.
FREM1-deficient mice faithfully recapitulate many of the phenotypes seen in individuals with FREM1 deficiency and that variations in GATA4 and SLIT3 expression modulate some FREM1-related phenotypes in mice.
Report role of Slit3 in development of the caval veins and pericardium.
Robo-2 (Montrer ROBO2 Protéines)-mediated targeting of P2 axons along the dorsoventral axis of the OB is controlled by Slit-3 expression
Study identify that the homeobox (Montrer PRRX1 Protéines) gene Nkx2-5 (Montrer NKX2-5 Protéines) is required for early ventral restriction of Slit3 and that the T-box transcription factor Tbx2 (Montrer TBX2 Protéines) mediates repression of Slit3 in nonchamber myocardium.
The chemorepellent Slit3 promotes monocyte migration.
During blood vessel development, Slit3 gene expression (and that of Slit2) are linked to posttranscriptional regulation of Robo receptors.
Data suggest that the Slit family of axon guidance molecules (Slit 1 (Montrer SLIT1 Protéines)-3) and their Robo 1 (Montrer ROBO1 Protéines) and 2 receptors contribute to the topographic targeting of basal vomeronasal axons.
Experiments with triple mutant mice demonstrate a key role for Slit3 signaling in vertebrate midline commissural axon guidance.
The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene.
slit homolog 3
, slit homolog 3 protein
, slit homolog 3 (Drosophila)
, slit homolog 3 protein-like
, multiple EGF-like domains protein 5
, multiple epidermal growth factor-like domains protein 5
, multiple epidermal growth factor-like domains 5