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Human SMURF1 Protein expressed in Wheat germ - ABIN1320726
Wang, Zhang, Weng, Qiao, Ma, Xiao, Yu, Pan, Sun et al.: Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in ... dans The Journal of biological chemistry 2013
Expression of Smurf1 was increased with WHO grade and was consistent with poor prognosis of gliomas.
Smurf1 interacts with and targets Securin (Montrer PTTG1 Protéines), an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation.
Smurf1 overexpression decreases USP25 (Montrer USP25 Protéines) protein turnover, and the E3 ligase enzymatic activity of Smurf1 is required for USP25 (Montrer USP25 Protéines) degradation.
SMURF1 can be potentially used as a clinical biomarker and target for novel treatment of human GC.
Uev1A (Montrer UBE2V1 Protéines) appears to be involved in the BMP signaling pathway in which it collaborates with a ubiquitin E3 ligase Smurf1 to promote Smad1 (Montrer GARS Protéines) degradation in a Ubc13 (Montrer UBE2N Protéines)-independent manner.
High smurf1 expression is associated with neoplasms.
activation of AMPK (Montrer PRKAA1 Protéines) upregulated Smad6 (Montrer SMAD6 Protéines) and Smurf1 and thereby enhanced their interactions, resulting in its proteosome-dependent degradation of ALK2 (Montrer ACRV1 Protéines).
we propose that the PKA-Smurf1-PIPKIgamma pathway has an important role in pulmonary tumorigenesis and imposes substantial clinical impact on development of novel diagnostic markers and therapeutic targets for lung cancer treatment.
SMU (Montrer MLXIP Protéines)RF1 is increased in patients with pulmonary arterial hypertension
Data suggest that SMURF1 is required for S phase progression; SMURF1 promotes ubiquitination-dependent degradation of WEE1 (Montrer WEE1 Protéines); these functions of SMURF1 appear to be linked and may be important in cell proliferation and tumorigenesis. (SMURF1 = SMAD specific E3 ubiquitin protein ligase 1; WEE1 (Montrer WEE1 Protéines) = wee 1 (Montrer WEE1 Protéines) homolog [S pombe] protein)
Six2 (Montrer SIX2 Protéines) mediates the protective effects of GDNF on damaged DA neurons by regulating Smurf1 expression.
TGF-beta (Montrer TGFB1 Protéines) inhibited osteoblastic differentiation by inducing the MAPK-ERK (Montrer MAPK1 Protéines) pathway which upregulated the expression of ubiquitin ligase (Montrer RNF123 Protéines) SMURF1 and resulted in reduced presence of osteogenic proteins.
demonstration that Smurf1 acts as a brake for integrin activation by controlling Kindlin-2 (Montrer FERMT2 Protéines) protein levels, a new mechanism that permits precise modulation of integrin-mediated cellular functions
miR (Montrer MLXIP Protéines)-140-5p and SMURF1 are key regulators of disease pathology in pulmonary arterial hypertension
Smurf1 is required for selective autophagy of Mycobacterium tuberculosis and host defense against tuberculosis infection.
Smurf1 regulates glucose metabolism and inhibits osteoblast differentiation. Smurf1 function requires the presence of serine 148 (S148) in Smurf1.
Smurf1 mediates NGF (Montrer NGFB Protéines) signaling and ubiquitinates RhoA (Montrer RHOA Protéines) in growth cones, regulating the need for local translation and degradation.
Smurf-mediated endocytosis of Patched1 (Montrer PTCH1 Protéines) is required in sonic hedgehog (Montrer SHH Protéines) signal reception
Inhibition of rhBMP-2-induced ALP (Montrer CCL21A Protéines) activity by intracellular delivery of SMURF1 in murine calvarial preosteoblast cells.
Data demonstrate that Smurf1 and Smurf2 (Montrer SMURF2 Protéines) have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.
In Xenopus embryos, the BMP pathway is a major physiological target of Smurf1. We propose that in normal development Smurf1 cooperates with secreted BMP antagonists to limit BMP signaling in dorsal ectoderm.
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.
Smad ubiquitination regulatory factor 1
, E3 ubiquitin-protein ligase SMURF1
, SMAD specific E3 ubiquitin protein ligase 1
, e3 ubiquitin-protein ligase SMURF1-like
, E3 ubiquitin ligase SMURF1
, SMAD-specific E3 ubiquitin-protein ligase 1
, Smad-specific E3 ubiquitin ligase 1
, SMAD ubiquitination regulatory factor 1