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GLT would confer protection against renal injury by protecting against lipid accumulation and glutathione depletion, at least in part, through suppression of ADA/XO/UA pathway.
ADA levels were found to be increased in polycystic ovary syndrome patients compared to controls.
Alanine scanning results showed that His17, Gly184, Asp295, and Asp296 exerted the greatest effects on protein energy, suggesting that they played crucial roles in binding to inhibitors.
Adenosine deaminase-1 is an immune regulator of the follicular helper T cell.Adenosine deaminase-1 interaction with CD26 is impaired during HIV infection.
Studied levels of mucin 16 (CA125), adenosine deaminase and midkine as tumor markers in nonsmall cell lung cancer-associated malignant pleural effusion.
The authors found significant neurological and cognitive alterations in untreated Adenosine Deaminase deficiency-severe combined immunodeficiency patients. These included motor dysfunction, EEG alterations, sensorineural hypoacusia, white matter and ventricular alterations in MRI as well as a low mental development index or IQ.
Results provide evidence that ADA SNPs rs12190871 and rs121908723 are risk factors for contracting tuberculous pericarditis.
this study shows that ADA is biomarker candidate for endometriosis
this study characterizes the long-term outcome of ADA-deficient patients, who survived 5 or more years after therapy
ADA levels were found to be higher among patients, and revealed a possible link between evening rise and severity of auditory hallucinations as well as morning rise and severity of avolition-apathy in patients with schizophrenia.
In this study, we compared the activity of human adenosine deaminase (hADA) expressed in transgenic seeds of three different plant species: pea (Pisum sativum L.), Nicotiana benthamiana L. and tarwi (Lupinus mutabilis Sweet). All three species were transformed with the same expression vector containing the hADA gene driven by the seed-specific promoter LegA2 with an apoplast targeting pinII signal peptide.
Simvastatin reversed IL-13-suppressed adenosine deaminase activity, leading to the down-regulation of adenosine signaling and inhibition osteopontin expression through the direct inhibition of IL-13-activated STAT6 pathway in COPD.
Mitochondrial Damage and Apoptosis Induced by Adenosine Deaminase Inhibition and Deoxyadenosine in Human Neuroblastoma Cell Lines
Adenosine deaminases ADA1 and ADA2 (ADAs) decrease the level of adenosine by converting it to inosine, which serves as a negative feedback mechanism. These results suggest the existence of a new mechanism, where the activation and survival of immune cells is regulated through the activities of ADA2 or ADA1 anchored to the cell surface.
Patients with tuberculous pleurisy who had high ADA values had a higher probability of manifesting pulmonary tuberculosis. High ADA values may help predict contagious pleuroparenchymal tuberculosis. The most common pulmonary involvement of tuberculous pleurisy showed a centrilobular nodular pattern.
our analysis shows that, mononuclear cells secretes ADA in response to leishmanial infection and the elevated serum ADA activity is associated with VL and PKDL, and serum ADA activity can be used as prognostic marker to monitor the course of the treatment.
association between the occurrence of polycystic ovary syndrome with altered ADA activity and genetic distribution of G22A and A4223C polymorphisms of the ADA1 gene
High level of ADA is associated with obesity.
diagnostic value of serum adenosine deaminase (ADA) activity as a useful tool to differentiate HIV mono- and co-infection, was investigated.
Platelet aggregation and adenosine deaminase (ADA) activity were evaluated in pregnant women living with some disease conditions including hypertension, diabetes mellitus and human immunodeficiency virus infection.
Pulmonary alveolar proteinosis in adenosine deaminase-deficient mice
Dietary regulation of adenosine deaminase activity in stomach, small intestine and spleen of mice
Data indicate that untreated murine adenosine deaminase ADA(-/-) Tregs show alterations in the plasma membrane CD39/CD73. ectonucleotidase machinery and limited suppressive activity via extracellular adenosine.
ADA is upregulated in NOD dendritic cells, which results in their exuberant and spontaneous activation, which triggers autoimmune T cell activation.
The catalytic mechanism of Mus musculus adenosine deaminase (ADA) has been studied by quantum mechanics and two-layered ONIOM calculations
Adenosine deaminase is necessary but not sufficient to confer puromycin aminonucleoside sensitivity to podocytes.
adenosine deaminase deficient results in deoxy-ATP accumulation and leads to reduced thymic T cell production
Transactivation by a duodenum-specific enhancer requires functional GATA4 binding sites
ADA-deficient B cells exhibit a higher propensity to undergo B cell receptor-mediated apoptosis than their wild-type counterparts, and suggest a role for ADA in the survival of cells during antigen-dependent responses.
This study provides a basis for investigating the folding kinetics of murine ADA and folding mechanisms of (beta/alpha)8-barrel proteins using 19F NMR sepctroscopy.
RUNX1 transcription factor plays a significant role in regulating Ada gene expression in the trophoblast cell lineage.
These findings suggest that the A(2A)R plays a protective role in the ADA-deficient model of pulmonary inflammation.
Progesterone may have an antiseizure effect with the additional finding that decreased levels of adenosine deaminase that would have resulted in increased adenosine levels that exerts anticonvulsant effect via GABA-A receptors.
ADA/A2B adenosine receptor double-knockout mice exhibited enhanced pulmonary inflammation and airway destruction
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency.
study concludes that dictyocaulosis alters NTPDase, 5'-nucleotidase, and ADA activities of cow naturally infected by the parasite Dictyocaulus viviparus, in consequence the enzymes act as inflammatory markers
It was concluded that oxidative stress occurs in cattle experimentally infected by F. hepatica, mainly due to excessive ROS production in the course of fasciolosis, contributing to hepatic damage, and that increased in hepatic adenosine deaminase (ADA) activity may contribute to the inflammatory process.
Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase
the transition-state structures of PfADA, HsADA, and bovine ADA (BtADA) solved using competitive kinetic isotope effects (KIE) and density functional calculations
This is the first report that an inhibitor molecule (EHNA) with a nucleoside framework binds to the open form of ADA and the first observation of conformational change of ADA in the crystalline state.
Data demonstrate that dipeptidyl peptidase II can form a complex with adenosine deaminase, but with one order of magnitude higher dissociation constant than that of DPPIV.
after the immunotherapy, the rabbits showed an increase in the E-ADA activity when compared with control (78.62%), contributing for the change in the immune response.
both oxygenation of the tissue and adenosine deaminase activity in the medium support both growth and proliferation of wing discs.
Extra-cellular adenosine may function as a signal for energy allocation during immune response.
Our results indicate that ADA inhibition, besides increasing the interstitial adenosine level, intensifies the atrial A1 adenosinergic function in another (thyroid hormone-sensitive) way, suggesting a new mechanism of action of ADA inhibition
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia.
, adenosine deaminase