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findings show that AGS3 is not required for planar divisions of neural progenitors in the mouse neocortex. AGS3 is not recruited to the cell cortex and does not rescue LGN (Montrer GPSM2 Protéines) loss of function.
We conclude that LPS (Montrer TLR4 Protéines) priming increases AGS3 levels, which enhances lysosomal function and increases the capacity of macrophages to eliminate intracellular pathogens.
level of basal autophagy, autophagic induction, autophagic flux, autophagic degradation and the anti-autophagic action in macrophages that lacked Galphai3 (Montrer GNAI3 Protéines), AGS3, or RGS19 (Montrer RGS19 Protéines); or had been treated with pertussis toxin, were similar to controls
AGS3 has a role in the regulation of G-protein signaling in the immune system
these results indicate that GRK6 (Montrer GRK6 Protéines) complexes with AGS3-Galphai2 (Montrer GNAI2 Protéines) to regulate CXCR2 (Montrer CXCR2 Protéines)-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane.
The present study demonstrates an important role for GPSM1 in controlling the dynamics of cyst progression in an orthologous mouse model of autosomal dominant polycystic kidney disease.
These data suggest that Gpsm1 acts through a novel receptor-independent mechanism to facilitate renal tubular epithelial cell proliferation and renal tubular regeneration.
AGS3 null mice exhibited a lean phenotype, reduced fat mass, and increased nocturnal energy expenditure.
The GPR (Montrer ALDH18A1 Protéines) motif in this protein and other proteins is actually associated with activity as a GDI - guanine nucleotide dissociation inhibitor and not GTPase (Montrer RACGAP1 Protéines) activator as initially suggested.
The G-protein Regulatory motif of AGS3 is critical for regulating MUC1/Muc1 (Montrer MUC1 Protéines) expression and cytokine production in the inflammatory microenvironment.
Data support the notion that the Galpha (Montrer SUCLG1 Protéines), but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 (Montrer TRPC4 Protéines) activation and unveil new roles for RGS (Montrer PITX2 Protéines) and AGS3 in fine-tuning TRPC4 (Montrer TRPC4 Protéines) activities.
Activator of G-protein Signaling 3 is an important regulator of esophageal squamous cell carcinoma proliferation
Results confirmed that Ric-8A (Montrer RIC8A Protéines) can directly bind to AGS3S but failed to facilitate Galpha (Montrer SUCLG1 Protéines)(i)-induced suppression of adenylyl cyclase, suggesting that it may not serve as a guanine exchange factor for AGS3/Galpha (Montrer SUCLG1 Protéines)(i/o)-GDP complex in a cellular environment.
High GPSM1 gene methylation is associated with gastric tumor aggressiveness.
Data identified three new loci for type 2 diabetes with genome-wide significance: MIR129-LEP (Montrer LEP Protéines), GPSM1 and SLC16A13 (Montrer SLC16A13 Protéines).
Our data indicate that decreased expression of AGS3 is correlated with reduced levels of p-CREB (Montrer CREB1 Protéines) in the apoptotic model. The negative role of AGS3 in cell apoptosis was further confirmed by knocking down AGS3.
These results provide mechanistic insights into how reversible modulation of Galpha(i3) activity by AGS3 and GIV maintains the delicate equilibrium between promotion and inhibition of autophagy.
AGS3 receptor coupling to both Galphabetagamma and GPR (Montrer ALDH18A1 Protéines)-Galpha (Montrer SUCLG1 Protéines)(i) offer additional flexibility for systems to respond and adapt to challenges and orchestrate complex behaviors
G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
G-protein-signaling modulator 1
, activator of G-protein signaling 3
, G-protein signaling modulator 1 (AGS3-like, C. elegans)
, G-protein signalling modulator 1 (AGS3-like, C. elegans)
, G-protein signaling modulator 1 (AGS3-like)
, G-protein signaling modulator 1 L homeolog