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Human Polyclonal GRK7 Primary Antibody pour IHC (p), ELISA - ABIN544410
Weiss, Ducceschi, Horner, Li, Craft, Osawa: Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2001
Show all 2 Pubmed References
Defects in GRK1 or GRK7 cause patients to suffer from an inability to properly deactivate rhodopsin leading to problems with recovery and dark adaptation.
Phosphorylation of GRK1 and GRK7 by PKA occurs in the dark, when cAMP levels in photoreceptor cells are elevated.
synthesis of 29 of GRK1 or GRK7 partial peptides that cover the entire sequence of GRK1/GRK7, to see which interacts with recoverin.
The function of a grk7 is essential for cone vision in the zebrafish retina and argue that pigment bleaching and spontaneous decay alone are not sufficient for light adaptation and rapid cone response inactivation.
In situ hybridization and immunohistochemical studies localizes both GRK1B and GRK7-1 in the cone outer segments.
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation.
g protein-coupled receptor kinase GRK7
, G protein-coupled receptor kinase 7
, G-protein-coupled receptor kinase 7
, G protein-coupled receptor kinase 7B
, G protein-coupled receptor kinase 7-2
, rhodopsin kinase 2