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Data identify Spn (Montrer SPN Kits ELISA) as a critical adhesion and signaling protein that is essential for modulating glioblastoma cell invasion in the brain microenvironment. Spn (Montrer SPN Kits ELISA) suppresses brain tumor cell invasion, in part, via control of Rac1 GTPase (Montrer RACGAP1 Kits ELISA) activities and invadopodia disassembly. Its C-terminus binds directly to the beta 8 integrin cytoplasmic tail.
results indicate that spinophilin plays an important role in regulating the activity of Group I mGluRs as well as their influence on synaptic activity.
Low spinophilin expression enhances aggressive biological behavior of breast cancer.
Colorectal carcinoma expression of spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance.
spinophilin might play a previously unrecognized role in the pathogenesis of head and neck squamous cell carcinoma
Spn (Montrer SPN Kits ELISA) downregulation contributes to a more aggressive biologic behavior, induces chemoresistance, and is associated with a poorer survival in patients with advanced stages of colorectal carcinoma.
study found a substantial number of hepatocellular carcinomas (HCC (Montrer FAM126A Kits ELISA)) show reduced or absent Spn (Montrer SPN Kits ELISA) expression; the low expression of Spn (Montrer SPN Kits ELISA) in tumour tissue is an independent negative prognostic factor for clinical outcome in HCC (Montrer FAM126A Kits ELISA); spinophilin expression inversely correlates with proliferative activity
Studies suggest that any change in substrate specificity of the spinophilin : PP1 (Montrer PPA1 PLURAL_@12788@) holoenzyme complex was probably due to direct modification of a PP1 (Montrer PPA1 PLURAL_@12788@) substrate binding surface.
Spinophilin associates with both delta- and mu-OmicronR and G protein subunits in HEK293 cells participating in a multimeric signaling complex that displays a differential regulatory role in opioid receptor signaling.
Spinophilin-deficient mice have enhanced antidepressant response to desipramine compared with wild-type controls.
two homologs neurabin and spinophilin play important yet distinct roles in the regulation of anxiety- and depression-like behaviors in an age-dependent manner.
COPS5 (Montrer COPS5 Kits ELISA) overexpression reduced spinophilin in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0.05), leading to significant deficits in learning and memory skills
RanBP9 (Montrer RANBP9 PLURAL_@4829@) overexpression in transgenic mice led to striking reduction in the levels of spinophilin.
Canonical betaAR-mediated signaling coupled to PKA activation results in phosphorylation of spinophilin, disrupting its interaction with alpha2AARs and accelerating alpha2AAR (Montrer ADRA2A Kits ELISA) endocytic responses.
Findings support the concept that the inhibitory effects of SPL (Montrer SGPL1 Kits ELISA) on M3R (Montrer CHRM3 Kits ELISA) activity are mediated by RGS4 (Montrer RGS4 Kits ELISA).
changes in spinophilin/CaMKII (Montrer CAMK2G Kits ELISA) interactomes may contribute to changes in striatal dendritic spine density, morphology, and function during normal postnatal maturation and aging.
these data suggest that spinophilin is an upstream regulator required for normal growth and excitation-contraction coupling, but is dispensable for beta-adrenergic stimulation of adult cardiomyocytes.
Findings suggest that spinophilin restrains Angiotensin II-mediated sympathetic nervous system activation and is an unrecognized molecule with regard to central blood pressure control
We suggest that Spn (Montrer SPN Kits ELISA) may be the tumor suppressor gene located at 17q21.33 acting through Rb regulation.
Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1\; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997
, neurabin 2
, neural tissue-specific F-actin-binding protein II
, nuerabin 2
, neurabin II
, protein phosphatase 1, regulatory (inhibitor) subunit 9B
, protein phosphatase 1, regulatory subunit 9B, spinophilin