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anti-Rat (Rattus) USP33 Anticorps:
anti-Human USP33 Anticorps:
anti-Mouse (Murine) USP33 Anticorps:
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Human Polyclonal USP33 Primary Antibody pour ELISA, WB - ABIN545156
Li, Na, Wang, Schoen, Messing, Wu: Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. dans The Journal of biological chemistry 2002
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Human Polyclonal USP33 Primary Antibody pour IHC (p), IP - ABIN258287
Shenoy, Modi, Shukla, Xiao, Berthouze, Ahn, Wilkinson, Miller, Lefkowitz: Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. dans Proceedings of the National Academy of Sciences of the United States of America 2009
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Our study reveals the inhibitory function of Slit-Robo signalling in gastric cancer (GC) and uncovers a role of USP33 in suppressing cancer cell migration and epithelial-mesenchymal transition by enhancing Slit2-Robo1 signalling. USP33 represents a feasible choice as a prognostic biomarker for GC.
USP33 was downregulated in gastric adenocarcinoma.
Fluorescence-activated cell sorting experiment found no significant effect of USP33 on cell cycle, whereas the apoptotic caspase proteins were activated by USP33-overexpression and the interaction between USP33 and Robo1 protein was identified, and knockdown of Robo1 enhancing the oncogenic effect upon USP33-knockdown, suggesting that USP33 may inhibit tumor progression through Robo1 signaling.
USP33 may indirectly regulate the degradation and recycling of CXCR4 through deubiquitinating beta-arrestin2, promoting colorectal tumor cell metastasis.
the E3 ligase beta-TrCP regulates cellular USP33 levels by the ubiquitin-proteasomal proteolysis.
Data show thata combining cyclin-dependent kinase 2 (CDK2) antagonism and ubiquitin thioesterase 33 (USP33) depletion augments anaphase catastrophe via changes in centrosomal protein of 110 kDa (CP110) protein expression.
Data show that ubiquitin specific peptidase 33 (USP33) mediates nerve tissue proteins Slit-Robo signaling in lung cancer cell migration.
USP33 as a previously unknown tumor-suppressing gene.
Knockdown or chemical inhibition of p97 causes robust accumulation of USP33 due to inhibition of its degradation
nutrient starvation induces RALB deubiquitylation by accumulation and relocalization of the deubiquitylase USP33 to RALB-positive vesicles
using human cells, identification of a new mechanism for the regulation of centrosome duplication that requires USP33, a deubiquitinating enzyme that is able to regulate CP110 levels
VDU1 has a role in amplifying the increase in type 2 iodothyronine deiodinase activity that results from catecholamine-stimulated de novo synthesis
The solution structure of the ZnF UBP domain of USP33 has been determined.
VDU1 was identified as a protein partner of hSP56.
USP33 and Mdm2 function reciprocally and favor respectively the stability or lability of the receptor beta-arrestin complex
USPs 20 and 33 serve as novel regulators that dictate both post-endocytic sorting as well as the intensity and extent of beta(2)AR signalling from the cell surface.
Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling
Data uncover a previously unknown function of USP33 and reveal a new player in Slit-Robo signaling in cancer cell migration.
This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms.
ubiquitin carboxyl-terminal hydrolase 33
, ubiquitin specific protease 33
, ubiquitin specific peptidase 33
, universal stress protein
, ubiquitin carboxyl-terminal hydrolase 33-like
, Deubiquitinating enzyme 33
, Ubiquitin thioesterase 33
, Ubiquitin-specific-processing protease 33
, ubiquitin thiolesterase 33
, VHL-interacting deubiquitinating enzyme 1
, deubiquitinating enzyme 33
, pVHL-interacting deubiquitinating enzyme 1
, ubiquitin thioesterase 33
, ubiquitin-specific-processing protease 33
, Vhlh-interacting deubiquitinating enzyme 1