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these findings indicate a role for CD300a in allergic inflammation and its resolution
The results indicate that CD300a on MCs and DCs regulates neutrophil recruitment into the peritoneal cavity after cecal ligation and puncture (CLP).
Epithelial apoptotic cells negatively regulated commensal-mediated signaling in dendritic cells via CD300a for Treg cell proliferation.
Data show that peroxisome proliferator activator receptor delta (PPARdelta/beta) directly regulates CD300a protein in macrophages.
These results suggest that CD300a is involved in aluminium-induced Th2 skewing.
study demonstrates a new tumor immune evasion mechanism that is mediated through the interaction between phosphatidylserine and CD300a and we suggest that CD300c, similarly to CD300a, also interacts with phosphatidylserine.
CD300a-deficient mice showed increased neutrophil recruitment and improved bacterial clearance in the peritoneal cavity.
These results indicated that CD300a is a new phosphatidylserine receptor.
Molecular cloning and characterization of leukocyte mono-immunoglobulin-like receptor1 and 2 derived from mast cells [LMIR1] [LMIR2]
in a murine model of allergic peritonitis, neutralization of the murine homolog of IRp60, LMIR1, led to a significantly augmented release of inflammatory mediators and eosinophilic infiltration.
Results provide an insight into the novel set of paired receptors CD300a and CD300c that are distinctively expressed on CD56(bright) natural killers (NK) cells with varied effector functions and show there differential binding to their ligands phosphatidylethanolamine and phosphatidylserine (PS) resulting in their differential ability to affect CD56(bright) NK cell functions.
High CD300A expression is associated with diffuse large B-cell lymphoma.
US3 protein kinase of pseudorabies virus triggers the binding of the inhibitory natural killer cell receptor CD300a to the surface of the infected cell, and protects of virus infected cells against natural killer cell-mediated lysis.
Overall, these data indicate that CD300a is a novel Dengue virus binding receptor that recognizes phosphatidylethanolamine and phosphatidylserine present on virions and enhance infection.
CD300a induction by the hypoxic environment represents a mechanism of regulation of monocyte/macrophage pro-inflammatory responses at pathologic sites
interaction with phosphatidylserines inhibits IgE/FcepsilonRI-dependent anaphylactic basophil degranulation
The inhibitory receptor CD300a is regulator of monocytes transendothelial migration.
SHP-1, but not SHP-2 or the src homology 2 domain containing inositol 5' phosphatase SHIP, was utilized by CD300a for its inhibitory activity. These studies provide new insights into the function of CD300a in tuning T and B cell responses.
CD300a is expressed on human peripheral blood basophils and rapidly up-regulated upon cross-linking of IgE/Fc-epsilon-RI and suppresses anaphylactic degranulation.
our results indicate that phosphatidylethanolamine and phosphatidylserine are ligands for CD300a, and that this interaction plays an important role in regulating the removal of dead cells.
CD300a blocked TLR4-mediated and TLR9-mediated expression of pro-inflammatory mediators without affecting TLR3-mediated events.
differential expression on human TH1 and TH17 cell memory subsets
Down-regulation of CD300a is associated with HIV infection.
CD300a is an inhibitory receptor expressed by human natural killer (NK) cells, but surprisingly, not all NK clones are inhibited in a CD300a-dependent manner.
CD300a(+) human Th1 cells tend to be polyfunctional and after stimulation up-regulate Eomes.
CMRF35A and CMRF35H have roles in immunoglobulin signaling; CMRF35H is an inhibitory molecule [review]
IRp60 is constitutively expressed on mast cells but is down-regulated by eosinophil major basic protein and eosinophil-derived neurotoxin. Cross-linking of IRp60 led to inhibition of IgE-induced degranulation and stem cell factor-mediated survival
Human neutrophils from peripheral blood express the ITIM containing CD300a (also known as IRp60 and CMRF-35H) receptor. Co-ligation of CD300a with (FcgammaRIIa) activation receptor inhibited CD32a mediated signalling.
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene.
, CD300 antigen-like family member
, CMRF35-like molecule 8
, CD300 antigen-like family member A
, leukocyte mono-Ig-like receptor 1
, mast cell-derived paired immunoglobulin-like receptor 1
, myeloid-associated immunoglobulin-like receptor 1
, polymeric immunoglobulin receptor 4
, CD300a antigen
, CMRF35H leukocyte immunoglobulin-like receptor
, NK inhibitory receptor
, immunoglobulin superfamily member 12
, inhibitory receptor protein 60
, leukocyte membrane antigen
, immune inhibitory receptor CD300A