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GIMAP5 loss-of-function mutation results in T cell deficiencies.
These data,demonstrating the downregulation of the mRNA and protein expression levels of GIMAP5 and GIMAP6 in the tumor tissues and blood of patients with HCC, suggested the involvement of GIMAP5 and GIMAP6 in the pathogenesis of HCC, and indicate their possible use as diagnostic markers for HCC.
gimap5 has a role in maintaining peripheral tolerance and T cell homeostasis in the gut [review]
Data indicate that overexpression of GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) in HEK (human embryonic kidney)-293 cells resulted in increased Ca2+ accumulation within the mitochondria.
Notch signalling protects T-ALL cells from apoptosis by upregulating the expression of GIMAP5.
These data establish Gimap5 as a key regulator of hematopoietic integrity and lymphocyte homeostasis
A significant increase in systemic lupus erythematosus risk associated with the most common GIMAP5 haplotype was found (odds ratio 1.26, 95% CI 1.02 to 1.54, p = 0.0033).
Resutls show that Gimap5 is located in the endoplasmic reticulum, and the endogenous Gimap5 mRNA is up-regulated in activated T-cells.
These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same single nucleotide polymorphism in another autoimmune disease.
Data show that IAN5 polymorphisms are associated with susceptibility to Systemic lupus erythematosus and the development of clinical disease manifestations in a strictly Korean population.
Gimap5 is a critical inhibitor of GSK3-beta in the CD4+ T cells.
functional Gimap5 is required for optimal signaling through TCR and IL-7R in T cells.
The defects in T-cell cellularity were more severe in mice lacking both Gimap3 and Gimap5.
a novel link between Gimap5 and Foxo expression and provide evidence for a regulatory mechanism that controls Foxo protein expression and may help to maintain immunological tolerance.
Gimap5 is an important stabilizer of mouse hematopoietic progenitor cell survival.
mouse gimap5 is necessary for the survival of peripheral T cells, NK/NKT-cell development, and the maintenance of normal liver function
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene.
GTPase IMAP family member 5
, immune associated nucleotide 4 like 1
, immunity associated protein 3
, immunity-associated nucleotide 5 protein
, inhibitor of radiation- and OA-induced apoptosis, Irod/Ian5
, immunity-associated nucleotide 4 protein
, immunity-associated nucleotide 4-like 1 protein
, immunity-associated protein 3
, GTPase, IMAP family member 5