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The mRNA levels of H2-d1 in the prefrontal cortex, hippocampus, and hypothalamus and C1qb in the hippocampus of the DBA/2 J strain were significantly down-regulated as compared to those in the C57BL/6 J strain
many self-peptides in the L(d) system (or the HLA-B system) would exhibit enhanced binding to Arg(97) alleles compared with Trp(97) alleles.
The identification and characterization of two CD4+ T cell epitopes of Lpp20 helps understand the protective immunity of Lpp20 in H.pylori infection.
Data show that At early stages, tumors demonstrated reduced MHC class I expression and increased expression of natural killer group 2D ligands (NKG2D-L).
Presentation of a new H-2D(k)-restricted epitope in the Tax protein of human T-lymphotropic virus type I is enhanced by the proteasome inhibitor lactacystin
A deecline in H-2D(B) and H-2D(K) expression with increasing thickness of cutaneous melanomas in transgenic mice and its reversal by interferon gamma therapy results implicate a regulatory defect as a principal cause of the loss of MHC class I antigens.
Coexpression of a Ly49A transgene partially rescued NKT cell development in Ly49D/H2-Dd transgenics.
efficient control of solid allogeneic tumors by NK cells depends on codelivery of both B7-1 and major histocompatibility complex class I (H-2Dd)on the tumor cells.
crystallization of murine MHC class I H-2Db in complex with human beta2-microglobulin
Data show that, despite the absence of H2-D1 and H2-K1 moecules, adult Purkinje cell in these transgenic mice are monoinnervated as in wild-type animals.
class I single-chain trimers are more immunogenic than even preprocessed Ag in the form of an epitope minigene
results show that neuronal MHC class Ia (H2-K(b)/D(b)) molecules are present in motor axons, are important for organization of neuromuscular junctions and motor recovery after nerve lesion, and that Schwann cells may mediate their actions
Involved in the presentation of foreign antigens to the immune system.
H-2 class I histocompatibility antigen, D-B alpha chain
, H-2D cell surface glycoprotein
, H2-DC1-beta transplantation antigen protein
, MHC H2-D-q alpha-chain
, MHC class I H-2Dp
, MHC class I H2 antigen
, Q5k protein