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Human Polyclonal HSPA1A Primary Antibody pour IHC (p), WB - ABIN3043849
Fan, Jiang, Yang, Liu, Song, Pan: Effects of adrenergic agents on stress-induced brain microstructural and immunochemical changes in adult male Wistar rats. dans Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2011
Show all 13 Pubmed References
Human Polyclonal HSPA1A Primary Antibody pour ICC, IHC (fro) - ABIN3044190
Yi, Peng, Chang, Peng, Yan, Lin: Effect of pre-moxibustion on apoptosis and proliferation of gastric mucosa cells. dans World journal of gastroenterology 2007
Show all 11 Pubmed References
Human Monoclonal HSPA1A Primary Antibody pour FACS, ICC - ABIN5693238
Wu, Cao, Gao, Chen, Wang, Zumbika, Qian: Down-modulation of heat shock protein 70 and up-modulation of Caspase-3 during schisandrin B-induced apoptosis in human hepatoma SMMC-7721 cells. dans World journal of gastroenterology 2004
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Human Monoclonal HSPA1A Primary Antibody pour IF, IHC - ABIN6675378
Hu, Zhou, Yang, Wang, Zheng, Li, Yan, Wu: Sulforaphane-N-Acetyl-Cysteine inhibited autophagy leading to apoptosis via Hsp70-mediated microtubule disruption. dans Cancer letters 2018
Human Monoclonal HSPA1A Primary Antibody pour FACS, IF - ABIN2722570
Chang, Chen, Lin, Chiang, Chang, Hsieh, Chen, Sun, Cheng: Irradiation Enhances Abscopal Anti-tumor Effects of Antigen-Specific Immunotherapy through Regulating Tumor Microenvironment. dans Molecular therapy : the journal of the American Society of Gene Therapy 2019
Human Monoclonal HSPA1A Primary Antibody pour FACS, IF - ABIN2722572
Ramdzan, Polling, Chia, Ng, Ormsby, Croft, Purcell, Bogoyevitch, Ng, Gleeson, Hatters: Tracking protein aggregation and mislocalization in cells with flow cytometry. dans Nature methods 2012
Cow (Bovine) Polyclonal HSPA1A Primary Antibody pour WB - ABIN2777745
Narjoz, Marisa, Imbeaud, Paris, Delacroix, Beaune, De Waziers: Genomic consequences of cytochrome P450 2C9 overexpression in human hepatoma cells. dans Chemical research in toxicology 2009
Perturbation of the HSP70-HSP90 heat-shock protein axis stimulates degradation of endothelial VEGFR2.
HSP70, the earliest induced gene in the zebrafish retina after optic nerve injury, is a crucial factor for retinal ganglion cell survival and optic nerve regeneration.
HSP70 mRNA and protein were increased 2.2 fold at 0.5-24 hours after optic nerve injury then returned to control level.
gene expression regulation in ZF4 cells by heat and cold
hsp70 is required for embryonic lens development.
data suggest that HSF1 is involved in regulating constitutive lens specific expression of hsp70 in the embryonic zebrafish.
in rheumatoid arthritis Significantly higher Hsp70 (heat shock protein 70) expression was found on synovial cells than on skin fibroblasts; high co-expression of CD91 and Hsp70 on RA synovial cells
These results demonstrate that induction of Hsp70 in response to heat stress is dependent on ERK activation in Pac2 cells.
Hsp70 levels above the median were associated with a higher rate of progression to the accelerated/blast phase and a tendency toward shorter survival
In contrast to wild-type mice, HSPA1A transgenic mice exhibited generalized seizures very early during the kindling paradigm.
CM-695, a small molecule that induces the expression of the HSPA1A/B genes, increases the vessel wall levels of Hsp70 and prevents thrombosis at least as efficiently as rivaroxaban without increasing bleeding risk.
HSPA1A and HSPA8 have roles in parturition through stimulating immune inflammatory and estrogen response
HSPA1A/B induction is a novel approach to delay thrombus formation with minimal bleeding risk in knockout mice.
HspA1A-phosphoinositide binding is complex yet specific, is mediated by both electrostatic and hydrophobic interactions, is not related to the lipid-head charge, and depends on the physicochemical properties of the lipid.
The protective mechanism of HAS2 involves an increased expression of the heat-shock protein Hsp72, a chaperone with antiapoptotic activity
HspA1A embeds in membranes when bound to liposomes composed of cardiolipin and sulfatide.The two domains of HspA1A differentially bind to lipids, such as cardiolipin and sulfatide.
Knockdown lines were created for specific DSBs in regions of the chromosome that are coding for HSPA1A. Clonogenic cell survival was significantly lower in irradiated Hsp70 KD cells with low mHsp70 expression, than in ctrl cells.
genetic manipulation of Hsp72 does not lead to alterations in metabolic processes in cardiac tissue under resting conditions, but identifies mouse strain-specific differences in cardiac lipid accumulation and insulin-stimulated glucose clearance.
Data indicate that heat shock protein 70 (Hsp70) is higher in nuclear protein 1 (Nupr1+/-) haplodeficient mice, concomitant with improved insulin sensitivity.
HuR does not play a role in APA of the Hsp70.3 mRNA, and these two regulatory events appear to be mutually exclusive regulators of Hsp70.3 expression
Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance.
Activation of HSP-72 upregulates lung injury associated with Pseudomonas aeruginosa pneumonia.
In HSP72 knockout mice, impaired Parkin action was associated with retention of enlarged, dysmorphic mitochondria and paralleled by reduced muscle respiratory capacity, lipid accumulation, and muscle insulin resistance.
AMPK inhibits hypertrophy through, in part, an HSP72-associated mechanism via miR-1 and protein degradation pathways in skeletal muscle cells.
Pleural mesothelial cells can release Hsp72 in response to bacterial infection.
In heat stress conditions, Hsp73 is mobilized to prevent apoptosis in the testes and epididymis, and assists Hsp72 in the repair of stress-altered protein conformations.
Hsp72 had greater affinity for tau than Hsc70, but Hsc70 was 30 times more abundant than Hsp72 in human and mouse brain tissue.
Toll-like receptor agonists and febrile range hyperthermia synergize to induce heat shock protein 70 expression and extracellular release
Hsp72 overexpression accelerates the recovery from acute pancreatitis and may represent a potential treatment strategy.
hsp72 was more potent than hsc73 in generating protective immune responses against the class Ia-negative 15/0 tumors.
The silencing of heat shock protein 70 (Hsp70) enhances the metastatic properties of the HeLa, A549 and MCF7 cancer cell lines. The inability of cells to form cadherincatenin complexes in the absence of Hsp70 stimulates their detachment from neighboring cells. Epithelialtomesenchymal transition (EMT) pathway is activated leading cancer cells to acquire a mesenchymal phenotype and a higher ability for migration.
the molecular chaperone activities of HSPA1A most probably by affecting the allosteric communication between its two major domains.
has been indicated that Hsp70 protein exerts a very important protective action and renders cells more resistant to the harmful effects of doxorubicin.
HSPA1A single nucleotide polymorphism rs1008438 was associated with chronic obstructive pulmonary disease in smokers.
binding of IL-5 to IL-5Ralpha receptors enhances angiogenic responses by stimulating the expression of HSP70-1 via the eNOS signaling pathway.
Downregulation of HSPA1A impaired mesenchymal stem cell osteogenic and chondrogenic differentiation.
HSPA1A overexpression promotes lipid accumulation in hepatocytes.
Study demonstrates that HSP72 inhibits HDACi-induced apoptosis in Jurkat cell line.
In conclusion, HSP70 modulates NF-kappaB activation in alveolar macrophages of TB patients, through inhibiting IkappaB-alpha phosphorylation or acting as a chaperon molecule to prevent NF-kappaB binding to the target genes by facilitating degradation. The upregulated HSP70 may suppress the release of pro-inflammatory cytokines during active pulmonary tuberculosis infection, and prevent overwhelming tissue damage.
that HSPA6 and HSPA1A contribute to protection of differentiated human neuronal cells from cellular stress
ultramarathon running caused a substantial increase in eHsp72 concentration, but probiotic + glutamine supplementation did not affect eHsp72 levels
uHSP72 may be considered as a novel potential diagnostic biomarker for the early detection of Diabetic nephropathy (DN). Moreover, these data support the pivotal role of NLRP3 in the development and progression of DN
The G allele of rs1008438G>T of HSPA1A may be a protective factor for cervical cancer among ethnic Han Chinese from Yunnan.
measurable HSP72 was not associated with graft versus host disease following allogeneic hematopoietic cell transplantation
studies demonstrated that ovarian cancer cells isolated from patients with type II tumors released high levels of immunosuppressive cytokines (i.e., interleukin 10 and transforming growth factor beta) and HspA1A in vitro.
This study suggests that logotherapy affects the expression of cortisol, BDI, and pain scales in advanced cervical cancer patients, and that it does not affect the expression of HSP70.
Data suggest that two putative NEF (nucleotide exchange factors) orthologs, GRPEL1 and GRPEL2, modulate function of mitochondrial HSP70 (mtHSP70); both GRPEL1 and GRPEL2 associate with mtHSP70 as hetero-oligomeric subcomplex and regulate mtHSP70 transport. (GRPEL = mitochondrial GrpE-like protein; HSP70 = heat-shock protein 70)
High HSP72 expression is associated with Cluster Amplified Centrosomes in cancer.
mRNA levels of HSP family members (HSP70B', HSP72, HSP40/DNAJ, and HSP20/CRYAB) are upregulated by the intracellular MMP3 overload.
Data suggest that both ATP- and peptide-binding domains of HSPA1A can form complexes with an AU-rich element in VEGFA mRNA in vitro; only peptide-binding domain can recover cellular VEGFA mRNA in ribonucleoprotein immunoprecipitation; RNA-binding and mRNA-stabilizing functions of HSPA1A are independent of its protein chaperone cycle. (HSPA1A = heat shock 70 kDa protein 1A; VEGFA = vascular endothelial growth factor A)
overexpression of the HSP70.2 gene in multiple organs of transgenic mice improves survival during heatstroke by reducing hyperthermia, circulatory shock, and cerebral ischemia and damage
In vitro acute heat stress and Geranylgeranylacetone induction increased the level of Hsp70 which upregulated the expression of TLR2/4 and NOD1/2 in both the cell cultured models. However, the expression level of TLR4 was found to be highest followed by NOD2, TLR2 and NOD1.
protects glutamatergic synaptic transmission in olfactory cortex cells, against acute anoxia
A new SNP in the 3'-UTR of the hsp 70-1 gene in Bos taurus and Bos indicus
The purified 44-kD ATPase domain from HSP70 exhibited intrinsic ATP-ADP exchange activity and acid-stable autophosphorylation at Thr204.
The effect of culture conditions on expression of heat shock protein 70 and Bax protein in bovine blastocysts is reported.
that HSC70 preconditioning (1) attenuates the TNF-alpha response to endotoxin in macrophages in vitro, (2) induces cardiac functional tolerance to endotoxin and (3) reduces NF-kappaB activity, and TNF-alpha and ICAM-1 levels in heart tissue.
the presence of SNPs (C/- and G/T) in the 5'-UTR region of inducible Hsp70.1 ameliorates HS response and tolerance to heat of bovine peripheral blood mononuclear cells
This study showed that Hsp70 concentration is a reliable indicator of chronic stress but is not a reliable indicator of a single stressor when animals are exposed to multiple chronic stressors.
Five novel SNPs located in the 3' flanking region of the inducible bovine HSP70A1A gene were identified in a Chinese Holstein population.
Heat shock increased both HSP70 and IFNT expression in blastocysts.
the promoter region of bovine hsp70.1 gene is polymorphic and may be useful in selection of dairy cows for relatively better thermotolerance and higher milk production.
More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 mRNA was present at highest levels in transgenic SCNT embryos.
In Sahiwal cattle the mRNA expression of HSP70 and its protein concentration were higher (P<0.05) during peak summer (44 degrees C) and winter (10 degrees C) as compared to Frieswal cattle. This investigation supports the earlier information on the higher adaptability of indigenous cattle breeds to hot and humid conditions compared to the crossbreds of temperate cattle breeds.
Inhibition of Hsp70 by using the Hsp70 inhibitor KNK437 or knock down Hsp70 using siRNA exaggerated and overexpression of Hsp70 prevented the second phase disruption of lung endothelial integrity.
Prostaglandin E synthase interacts with inducible heat shock protein 70 after heat stress in bovine primary dermal fibroblast cells.
Hsp70-1A is a biomarker of low beef tenderness across the cattle breeds. [HSP70-1a]
It is suggested that 9 SNPs increase the susceptibility to mastitis due to their low polymorphisms and can be used as molecular markers to breed the dairy cows resistant to mastitis.
The present study was carried out to analyze the expression of heat shock proteins in different tissues and to contrast heat stress phenotypes in response to chronic heat stress.
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
, heat shock 70kD protein 1A
, stress protein HSP70
, heat shock 70kDa protein 1A
, 68 kDa heat shock protein
, heat shock 70 kDa protein 1A
, heat shock 70 kDa protein 3
, heat shock protein, 70 kDa 3
, inducible heat shock protein 70
, heat shock 70 kDa protein 1/2
, heat shock 70 kDa protein 1A/1B
, heat shock protein 70-1
, dnaK-type molecular chaperone HSP70-1
, heat shock-induced protein
, heat shock 70 kDa protein 1B
, heat shock 70 kDa protein 2
, heat shock 70kDa protein 1B
, 70 kda heat shock protein-2
, heat shock 70 kD protein 2
, heat-shock 70-kilodalton protein 1B
, heat shock protein 70
, heat shock protein 70.1
, heat-shock protein 70