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Human mucosal-associated invariant T cells possess capacity for B cell help via MR1-mediated immunoglobulins production.
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Early endosomal TLR9 activation is important for MR1-mediated bacterial antigen presentation in B cells.
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Polymorphism in MR1 gene is associated with susceptibility to tuberculosis.
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we have shown that MR1-mediated MAIT cell activation is tightly regulated at several levels. Efficient MR1-mediated MAIT cell activation requires both intact bacteria to access an acidified endolysomal compartment and activation of the APC through NF-kappaB or interferon signaling pathways.
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results suggest that high expression of MR-1 is involved in hepatocellular carcinoma progression
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Data show that the major histocompatibility complex, class I-related protein (MR1) antigen presentation is characterized by a rapid 'off-on-off' mechanism that is strictly dependent on antigen availability.
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endosome-mediated trafficking of MR1 allows for selective sampling of the intracellular environment
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Studies indicate that the antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells.
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Data indicate that high expression of CD26 ia a specific markers to define major histocompatibility complex, class I-like sequence protein MR1-restricted mucosa-associated invariant T (MAIT) cells.
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Mucosal-associated invariant T cell adaptation was a direct consequence of exposure to various exogenous MR1-restricted epitopes.
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[review] Mucosal-associated invariant T-cell (MAIT) T-cell antigen receptor recognizes riboflavin and folic acid metabolites bound by MR1 in a conserved docking mode and thus acts like a pattern recognition receptor.
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MR1 tetramers allow precise phenotypic characterization of human and mouse mucosal-associated invariant T cells.
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A novel MR1B isoform probably plays a physiological role complementary to MR1A with respect to mucosal-associated invariant T cells development and/or function.
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Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress.
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metabolites of vitamin B represent a class of antigen that are presented by MR1 for MAIT-cell immunosurveillance; as many vitamin biosynthetic pathways are unique to bacteria and yeast, data suggest that MAIT cells use these metabolites to detect microbial infection
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Mutagenesis of MR1 showed that only two residues, which were centrally positioned and on opposing sides of the antigen-binding cleft of MR1, were essential for MAIT cell activation
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Taken together these results strongly suggest that MR1 needs to bind proteasome-independent ligands in order to properly reach the cell surface.
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fact that MR1 seems mainly intracellular might offer clues as to the process, given the precedence in other class I molecules
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MR1 molecules can associate with the peptide-loading complex and can be detected at low levels at the surface of transfected cells.
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Our results demonstrated a preferential association of MR1 with beta(2)-microglobulin in MHC class I-deficient B cell lines.
