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PVRL2 is a plasma cholesterol-responsive gene acting at endothelial sites of vascular inflammation to regulate transendothelial migration of leukocytes.
Results suggest that modulation of the expression of receptors and CD112 compensates for CD155 deficiency in immune surveillance against methylcholanthrene-induced tumors.
We showed that cadherin and nectin in the junctions of A431 cells and human keratinocytes are located in separate clusters.
nectin-afadin system plays essential roles in coupling cell-cell adhesion and the cortical actin scaffold in spermatids at Sertoli-spermatid junctions and in subsequent sperm morphogenesis
Our functional analyses indicate that the infertility phenotype of nectin-2-deficient male mice is caused by a combination of reduced migration to the oviduct, spermatozoa-zona binding, and sperm-oocyte fusion
nectins and afadin are involved in dynamic epithelial remodeling during mouse development
Nectin-2 expression in Sertoli cells is believed via cross-talking between CREB, c-Jun, and Sp1 family protein.
Inactivated nectin-2 and nectin-3 disrupted the nectin-afadin-actin system, and finally the actin filaments disappeared. As a result, the specialization lost the holding function and detachment of spermatids was observed.
expressed in early epithelial structures of the nephron generated from metanephric mesenchyme
Nectin-2 is required to maintain structure and function of the intercalated disc and protects the heart from pressure-overload-induced cardiac dysfunction.
Nectin-2 mutation in men with severe teratospermia
In the infection with 3 MLD50 (50 % mouse lethal dose), effective resistance was not observed in transgenic mice expressing nectin-2Ig.
Our data provide important structural and biochemical determinants responsible for the recognition of nectin-2 by TIGIT.
Chromosomal breakpoints involved the PVRR2 gene in 19q31 is associated with Diffuse Large B-Cell Lymphomas.
energetic basis for the TIGIT/nectin-2 interaction and revealed that an "aromatic key" of nectin-2 is critical for this interaction, whereas variations in the lock were tolerated.
Serum levels of nectin-2 may have diagnostic roles for colorectal cancer patients.
Soluble form of nectin-2 is required for exerting the resistance against HSV-2 infection.
PVRL2, TOMM40 and APOE might be associated with human longevity.
Nectin-3 trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation.
Chorionic gonadotropin induces vascular endothelial growth factor (VEGFA)-dependent downregulation of nectin 2, which increases the endothelial permeability in the coculture system.
Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion.
Data show that a high expression of CD112 and CD155 (DNAM-1 ligands) on leukemic blasts.
a possible etiologic role of PRR2 in nonsyndromic cleft lip with or without cleft palate
The CD112 is highly expressed in colon carcinoma tissues and cell lines.
The authors now show that human cytomegalovirus targets CD112 for proteasome-mediated degradation by 48 h post-infection, thus removing both activating ligands for DNAM-1 from the cell surface during productive infection.
Data show that both PVR and Nectin-2 represent specific ligands for the DNAM-1 triggering receptor.
differences in the N termini of herpes simplex virus type 1 and 2 gDs that influence functional interactions with the human entry receptor Nectin-2
Analysis of the ligands for triggering NK receptors revealed the consistent expression of cd155 and cd112 in myeloid leukemias, and less frequent expression in lymphoblastic leukemias
There is an allelic association of sequence variation in PVRL2 and the severity of multiple sclerosis.
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
poliovirus receptor-related protein 2
, herpes virus entry mediator B
, herpesvirus entry mediator B
, murine herpes virus entry protein B
, murine herpesvirus entry protein B
, poliovirus receptor homolog
, poliovirus sensitivity
, poliovirus receptor related 2
, poliovirus receptor-related 2 (herpesvirus entry mediator B)
, herpesvirus entry protein B
, poliovirus receptor-like 2