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this study describes SLy1 as an immunoregulatory protein, which is involved in the generation of adaptive immune responses during L. monocytogenes infection, and provides a model of how SLy1 regulates T-cell proliferation.
Sly1 is an essential molecular component for the full activation of adaptive immunity
expression of the Notch (Montrer NOTCH1 Protéines) signaling mediator RBP-J (Montrer RBPJ Protéines) and the Notch (Montrer NOTCH1 Protéines) target genes Hes-1 and Hes-5 (Montrer HES5 Protéines) was markedly reduced in MZ but not FO B cells of Sly1(d/d) mice.
anti-apoptotic protein required for T cell differentiation to the CD4 (Montrer CD4 Protéines)+CD8 (Montrer CD8A Protéines)+ stage, likely to be involved in mTOR (Montrer FRAP1 Protéines) complex activation
The protein encoded by this gene contains a Src homology-3 (SH3) domain and a sterile alpha motif (SAM), both of which are found in proteins involved in cell signaling. This protein may function as a signaling adapter protein in lymphocytes.
SAM and SH3 domain containing 3
, SAM and SH3 domain-containing protein 3
, SH3 protein expressed in lymphocytes homolog
, Novel SH3 and SAM domain containing protein
, SH3 protein expressed in lymphocytes