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Human Angiopoietin-Like 4 (ANGPTL4) interaction partners

1. Studied association of plasma angiopoietin like 4 (ANGPTL4), plasma lipid levels levels, and body mass index in both normal weight and obese children and adolescents. Results showed a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile.

2. knockdown of ANGPTL-4 suppressed HG-induced cell proliferation, inflammatory response, and ECM accumulation inhibiting NF-kappaB signaling pathway in MCs

3. We show that the PPARb/d inverse agonist PT-S264 impairs transcription initiation by decreasing recruitment of activating Mediator subunits, RNA polymerase II, and TFIIB, but not of TFIIA, to the ANGPTL4 promoter.

4. ANGPTL4 is down-regulated in gestational diabetes mellitus and participates in promoting insulin resistance and secretion of inflammatory cytokines.

5. Recently two proteins, angiopoietin-like protein 3 and 4, have emerged from genetic studies as being factors that significantly modulate plasma triglyceride levels and coronary artery disease. ..Here we report the crystal structures of the fibrinogen-like domains of both proteins. These structures offer new insights into the reported loss of function mutations

6. G allele at the rs116843064 polymorphic locus of the ANGPTL4 gene was associated with a lower prevalence of metabolic syndrome (MetS).

7. valuable insights into the relationship between ANGPTL4 and LPL in human adipose tissue

8. Data suggest that angiopoietin like-4 (ANGPTL4) contributes to pathological vascular remodelling in capillary cerebral amyloid angiopathy and that detection of ANGPTL4 levels may improve current diagnostics.

9. Molecular mechanisms by which ANGPTL4 functions in eye diseases, such as diabetic retinopathy, age-related macular degeneration and uveal melanoma.[review]

10. ANGPTL4 is uniquely induced by hypoxia in cultured SGC cells and is essential for tumour growth and resistance to anoikis through different mechanisms.

11. Gastric antral vascular ectasia in liver cirrhosis is associated with increased expression of miR-3667 maybe linked with ANGPTL4 gene.

12. Adipocyte-derived ANGPTL4 drives disease progression under obese conditions and is a potential therapeutic target for treating obese breast cancer patients.

13. the action of PVT1 is moderately attributable to its repression of ANGPTL4 via association with the epigenetic repressor Ezh2.

14. Taken together, our data suggest that serum ANGPTL3 and 4 levels are influenced by nutritional status and fasting and could be involved in the metabolic disturbances present in obesity and anorexia nervosa.

15. ANGPTL4 was immunohistochemically detectable in 76 out of 109 osteosarcoma cases. ANGPTL4 was induced by hypoxia in 6 osteosarcoma cell lines, under the control of the HIF-1alpha transcription factor.

16. Carriers of p.E40K, a variant that abolishes ANGPTL4 ability to inhibit lipoprotein lipase, have lower odds of T2D (odds ratio 0.89, 95% confidence interval 0.85-0.92, p = 6.3 x 10(-10)), lower fasting glucose, and greater insulin sensitivity.

17. A relevant role of ANGPTL-4 in human obesity and its involvement in long-term body weight changes.

18. Data indicate that the angiopoietin-like protein 4 (ANGPTL4)-mediated upregulation of tristetraprolin expression regulates the stability of chemokines in human colon epithelial cells.

19. The data suggest that exercise-induced ANGPTL4 is secreted from the liver and driven by a glucagon-cAMP-PKA pathway in humans. These findings link the liver, insulin/glucagon, and lipid metabolism together.

20. Study data support dual roles for ANGPTL4 in urothelial carcinoma progression, either as a tumor suppressor or oncogene, in response to microenvironmental context.

Mouse (Murine) Angiopoietin-Like 4 (ANGPTL4) interaction partners

1. Angptl4 increases the maximum mitochondrial oxidative capacity through AMPK activation in skeletal muscle cells. Lack of Angptl4 mitigates exercise-induced skeletal muscle AMPK activation. Angptl4-deficient mice show a lower endurance to exercise

2. Adipose Tissue ANGPTL4 in regulating peripheral lipid deposition, influencing whole-body lipid and glucose metabolism and the progression of atherosclerosis.

3. GPIHBP1-independent pathway for clearance of plasma TGs in Angptl4(-/-)Gpihbp1(-/-) mice

4. Adipocyte-derived ANGPTL4 drives disease progression under obese conditions and is a potential therapeutic target for treating obese breast cancer patients.

5. BAT specific deletion of ANGPTL4 results in enhanced lipoprotein lipase activity, circulating triglyceride clearance and thermogenesis. Absence of ANGPTL4 in BAT increased fatty acid oxidation and reduced fatty acid synthesis.

6. ANGPTL4 promotes PCSK-mediated intracellular cleavage of LPL in adipocytes, likely contributing to regulation of LPL in adipose tissue.The data provide further support for an intracellular action of ANGPTL4 in adipocytes.

7. inactivation of ANGPTL4 improves glucose tolerance, at least partly via a gut microbiota-dependent mechanism

8. miR-134 accelerates atherogenesis by promoting lipid accumulation and proinflammatory cytokine secretion via the ANGPTL4/LPL pathway

9. Functional studies in Angptl4-deficient mice confirm improved insulin sensitivity and glucose homeostasis.

10. Data show that angiopoietin-like protein 4 (ANGPTL4)deficiency in mice knockout (ANGPTL4(-/-)) exacerbated colonic inflammation induced by dextran sulfate sodium (DSS) or stearic acid.

11. Angptl4 is induced early in fasting to divert uptake of fatty acids and triglycerides away from adipose tissues.

12. haematopoietic ANGPTL4 deficiency increases atherogenesis through regulating myeloid progenitor cell expansion and differentiation, foam cell formation and vascular inflammation.

13. Following ANGPTL4 downregulation, the proliferation and invasion abilities of gastric cancer (GC)cell lines were suppressed as determined by MTT and Transwell assays, and cell apoptosis level and sensitivity to cisplatin were increased as determined by flow cytometry and MTT assay. In conclusion, these findings suggest that ANGPTL4 may be a new potential therapeutic target for GC

14. The influence of H2O2 on ANGPTL4 provided new insight into the mechanism of atherosclerosis.

15. The reduction of plasma triglyceride levels in Angptl4(-/-) mice and increase following Angptl4 overexpression suggest that changes in plasma triglyceride metabolism do not regulate alpha-cells in the pancreas. Our findings corroborate recent data showing that increased plasma amino acids and their transport into alpha-cells link glucagon receptor blockage to alpha-cell hyperplasia

16. study demonstrates the key role of Angptl4 in glucocorticoid-augmented hepatic ceramide production that induces whole-body insulin resistance.

17. 1) ANGPTL4 is not involved in the triglyceride-lowering effect ofbile acids ; 2) ANGPTL4 promotes bile acids absorption during taurocholic acid supplementation via a mechanism dependent on the gut microbiota.

18. physiological changes in adipose tissue ANGPTL4 expression during fasting and cold resulted in inverse changes in the amount of mature-glycosylated LPL in wild-type mice, but not Angptl4(-/-) mice. We conclude that ANGPTL4 promotes loss of intracellular LPL by stimulating LPL degradation after LPL processing in the endoplasmic reticulum (ER).

19. This study shows that TNF-alpha, by a Foxo1 dependent pathway, increases the transcription of ANGPTL4 which is secreted by the cells and causes inactivation of LPL.

20. Angptl4-deficient mice show impaired insulin secretion and dysmorphic pancreatic islets.

Pig (Porcine) Angiopoietin-Like 4 (ANGPTL4) interaction partners

1. The ANGPTL4 G/A polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) showed a significant effect on intramuscular fat

Cow (Bovine) Angiopoietin-Like 4 (ANGPTL4) interaction partners

1. increase in angiopoietin-like protein 4 messenger RNA across multiple models of altered energy balance identifies it as an adipokine that is uniquely responsive to changes in energy balance in the lactating dairy cow

2. These findings indicate that liver and adipose tissue are key sources of ANGPTL4 in cattle; the protein was also highly abundant in ruminal epithelium, making it possible that commensal microbes may influence ANGPTL4 synthesis and secretion.

Zebrafish Angiopoietin-Like 4 (ANGPTL4) interaction partners

1. These results suggest that the microbiota might regulate host intestinal Angptl4 protein expression and peripheral fat storage by suppressing the activity of an intestine-specific transcriptional enhancer.