Aperçu des produits pour anti-ANGPTL4 (ANGPTL4) Anticorps

Human Angiopoietin-Like 4 (ANGPTL4) interaction partners

1. Low ANGPTL4 expression is associated with childhood obesity.

2. SNP rs11672433, a high-frequency locus in the ANGPTL4 gene, does not influence the predisposition to brain arteriovenous malformation or its effect is too small to be detected in the present size sample set.

3. Levels of ANGPTL4 in the circulation and HDLs (Montrer CSF1R Anticorps) were increased in type 2 diabetics altering lipid metabolism.

4. High expression of ANGPTL4 is associated with drug resistance in prostate cancer.

5. circulating ANGPTL3 (Montrer ANGPTL3 Anticorps) and ANGPTL 4 expression was significantly elevated in hepatocellular carcinoma cases compared to chronic hepatitis patients and controls

6. this study suggests that the presence of C allele of rs1044250 and G allele of rs2278236 in ANGPTL4 gene is associated with higher risk of moderate/severe proteinuria in renal transplant patients

7. These results suggested that ANGPTL4 was essential for proliferation and metastasis of lung cancer cells.

8. The mutant tumors exhibited impaired proliferation, anoikis resistance, and migratory capability and had reduced adenylate energy charge. Further investigations also revealed that cANGPTL4 regulated the expression of Glut2 (Montrer SLC2A2 Anticorps)

9. Data indicate angiopoietin-like 4 (ANGPTL4) as a key player that coordinates an increase in cellular energy flux crucial for EMT (Montrer ITK Anticorps) via an ANGPTL4/14-3-3gamma (Montrer YWHAG Anticorps) signaling axis.

10. The authors now show: (1) that ANGPTL4 inactivates LPL (Montrer LCP1 Anticorps) by catalyzing the unfolding of its hydrolase domain; (2) that binding to GPIHBP1 (Montrer GPIHBP1 Anticorps) renders LPL (Montrer LCP1 Anticorps) largely refractory to this inhibition; and (3) that both the LU domain and the intrinsically disordered acidic domain of GPIHBP1 (Montrer GPIHBP1 Anticorps) are required for this protective effect.

Cow (Bovine) Angiopoietin-Like 4 (ANGPTL4) interaction partners

1. increase in angiopoietin-like protein 4 messenger RNA across multiple models of altered energy balance identifies it as an adipokine that is uniquely responsive to changes in energy balance in the lactating dairy cow

2. These findings indicate that liver and adipose tissue are key sources of ANGPTL4 in cattle; the protein was also highly abundant in ruminal epithelium, making it possible that commensal microbes may influence ANGPTL4 synthesis and secretion.

Mouse (Murine) Angiopoietin-Like 4 (ANGPTL4) interaction partners

1. Following ANGPTL4 downregulation, the proliferation and invasion abilities of gastric cancer (GC)cell lines were suppressed as determined by MTT and Transwell assays, and cell apoptosis level and sensitivity to cisplatin were increased as determined by flow cytometry and MTT assay. In conclusion, these findings suggest that ANGPTL4 may be a new potential therapeutic target for GC

2. The influence of H2O2 on ANGPTL4 provided new insight into the mechanism of atherosclerosis.

3. The reduction of plasma triglyceride levels in Angptl4(-/-) mice and increase following Angptl4 overexpression suggest that changes in plasma triglyceride metabolism do not regulate alpha-cells in the pancreas. Our findings corroborate recent data showing that increased plasma amino acids and their transport into alpha-cells link glucagon receptor (Montrer GCGR Anticorps) blockage to alpha-cell hyperplasia

4. study demonstrates the key role of Angptl4 in glucocorticoid-augmented hepatic ceramide production that induces whole-body insulin (Montrer INS Anticorps) resistance.

5. 1) ANGPTL4 is not involved in the triglyceride-lowering effect ofbile acids ; 2) ANGPTL4 promotes bile acids absorption during taurocholic acid supplementation via a mechanism dependent on the gut (Montrer GUSB Anticorps) microbiota.

6. physiological changes in adipose tissue ANGPTL4 expression during fasting and cold resulted in inverse changes in the amount of mature-glycosylated LPL (Montrer LPL Anticorps) in wild-type mice, but not Angptl4(-/-) mice. We conclude that ANGPTL4 promotes loss of intracellular LPL (Montrer LPL Anticorps) by stimulating LPL (Montrer LPL Anticorps) degradation after LPL (Montrer LPL Anticorps) processing in the endoplasmic reticulum (ER).

7. This study shows that TNF-alpha (Montrer TNF Anticorps), by a Foxo1 (Montrer FOXO1 Anticorps) dependent pathway, increases the transcription of ANGPTL4 which is secreted by the cells and causes inactivation of LPL (Montrer LPL Anticorps).

8. Angptl4-deficient mice show impaired insulin (Montrer INS Anticorps) secretion and dysmorphic pancreatic islets.

9. Angptl4 induces obesity-associated metabolic disorders. The present study suggested that Angptl4 promotes liver steatosis and lipolysis, in addition to impairing liver function; while Angptl4 improves glucose tolerance and insulin (Montrer INS Anticorps) resistance, in addition to causing the downregulation of various insulin (Montrer INS Anticorps) signaling pathway-associated genes.

10. ANGPTL4 is part of a shuttling mechanism that directs fatty acids derived from circulating triglyceride-rich lipoproteins to brown adipose tissue during cold.

Pig (Porcine) Angiopoietin-Like 4 (ANGPTL4) interaction partners

1. The ANGPTL4 G/A polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) showed a significant effect on intramuscular fat

Zebrafish Angiopoietin-Like 4 (ANGPTL4) interaction partners

1. These results suggest that the microbiota might regulate host intestinal Angptl4 protein expression and peripheral fat storage by suppressing the activity of an intestine-specific transcriptional enhancer.