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anti-Human ANGPTL4 Anticorps:
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Human Polyclonal ANGPTL4 Primary Antibody pour FACS, IHC (p) - ABIN653155
Wan, Wen, Dong, Tang, Liu, Liu, Tao, Gao, Sun, Cao, Fan, Wu: Establishment of monoclonal HCC cell lines with organ site-specific tropisms. dans BMC cancer 2015
Show all 2 Pubmed References
Human Polyclonal ANGPTL4 Primary Antibody pour ELISA, WB - ABIN1169313
Broxmeyer, Srour, Cooper, Wallace, Hangoc, Youn: Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors. dans Blood cells, molecules & diseases 2012
Human Polyclonal ANGPTL4 Primary Antibody pour WB - ABIN526478
Makoveichuk, Sukonina, Kroupa, Thulin, Ehrenborg, Olivecrona, Olivecrona: Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 are formed. dans Biochemical and biophysical research communications 2012
Human Polyclonal ANGPTL4 Primary Antibody pour ELISA, WB - ABIN565533
Yokouchi, Eto, Nishimura, Takeda, Kaburagi, Yamamoto, Yasuda: Angiopoietin-like protein 4 (ANGPTL4) is induced by high glucose in retinal pigment epithelial cells and exhibits potent angiogenic activity on retinal endothelial cells. dans Acta ophthalmologica 2013
Study data support dual roles for ANGPTL4 in urothelial carcinoma progression, either as a tumor suppressor or oncogene (Montrer RAB1A Anticorps), in response to microenvironmental context.
ANGPTL4 levels are increased in both plasma and adipose tissues of subjects with hypertension.
Low ANGPTL4 expression is associated with childhood obesity.
SNP rs11672433, a high-frequency locus in the ANGPTL4 gene, does not influence the predisposition to brain arteriovenous malformation or its effect is too small to be detected in the present size sample set.
Levels of ANGPTL4 in the circulation and HDLs (Montrer CSF1R Anticorps) were increased in type 2 diabetics altering lipid metabolism.
High expression of ANGPTL4 is associated with drug resistance in prostate cancer.
circulating ANGPTL3 (Montrer ANGPTL3 Anticorps) and ANGPTL 4 expression was significantly elevated in hepatocellular carcinoma cases compared to chronic hepatitis patients and controls
this study suggests that the presence of C allele of rs1044250 and G allele of rs2278236 in ANGPTL4 gene is associated with higher risk of moderate/severe proteinuria in renal transplant patients
These results suggested that ANGPTL4 was essential for proliferation and metastasis of lung cancer cells.
The mutant tumors exhibited impaired proliferation, anoikis resistance, and migratory capability and had reduced adenylate energy charge. Further investigations also revealed that cANGPTL4 regulated the expression of Glut2 (Montrer SLC2A2 Anticorps)
increase in angiopoietin-like protein 4 messenger RNA across multiple models of altered energy balance identifies it as an adipokine that is uniquely responsive to changes in energy balance in the lactating dairy cow
These findings indicate that liver and adipose tissue are key sources of ANGPTL4 in cattle; the protein was also highly abundant in ruminal epithelium, making it possible that commensal microbes may influence ANGPTL4 synthesis and secretion.
haematopoietic ANGPTL4 deficiency increases atherogenesis through regulating myeloid progenitor cell expansion and differentiation, foam cell formation and vascular inflammation.
Following ANGPTL4 downregulation, the proliferation and invasion abilities of gastric cancer (GC)cell lines were suppressed as determined by MTT and Transwell assays, and cell apoptosis level and sensitivity to cisplatin were increased as determined by flow cytometry and MTT assay. In conclusion, these findings suggest that ANGPTL4 may be a new potential therapeutic target for GC
The influence of H2O2 on ANGPTL4 provided new insight into the mechanism of atherosclerosis.
The reduction of plasma triglyceride levels in Angptl4(-/-) mice and increase following Angptl4 overexpression suggest that changes in plasma triglyceride metabolism do not regulate alpha-cells in the pancreas. Our findings corroborate recent data showing that increased plasma amino acids and their transport into alpha-cells link glucagon receptor (Montrer GCGR Anticorps) blockage to alpha-cell hyperplasia
study demonstrates the key role of Angptl4 in glucocorticoid-augmented hepatic ceramide production that induces whole-body insulin (Montrer INS Anticorps) resistance.
1) ANGPTL4 is not involved in the triglyceride-lowering effect ofbile acids ; 2) ANGPTL4 promotes bile acids absorption during taurocholic acid supplementation via a mechanism dependent on the gut (Montrer GUSB Anticorps) microbiota.
physiological changes in adipose tissue ANGPTL4 expression during fasting and cold resulted in inverse changes in the amount of mature-glycosylated LPL (Montrer LPL Anticorps) in wild-type mice, but not Angptl4(-/-) mice. We conclude that ANGPTL4 promotes loss of intracellular LPL (Montrer LPL Anticorps) by stimulating LPL (Montrer LPL Anticorps) degradation after LPL (Montrer LPL Anticorps) processing in the endoplasmic reticulum (ER).
This study shows that TNF-alpha (Montrer TNF Anticorps), by a Foxo1 (Montrer FOXO1 Anticorps) dependent pathway, increases the transcription of ANGPTL4 which is secreted by the cells and causes inactivation of LPL (Montrer LPL Anticorps).
Angptl4-deficient mice show impaired insulin (Montrer INS Anticorps) secretion and dysmorphic pancreatic islets.
Angptl4 induces obesity-associated metabolic disorders. The present study suggested that Angptl4 promotes liver steatosis and lipolysis, in addition to impairing liver function; while Angptl4 improves glucose tolerance and insulin (Montrer INS Anticorps) resistance, in addition to causing the downregulation of various insulin (Montrer INS Anticorps) signaling pathway-associated genes.
The ANGPTL4 G/A polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) showed a significant effect on intramuscular fat
These results suggest that the microbiota might regulate host intestinal Angptl4 protein expression and peripheral fat storage by suppressing the activity of an intestine-specific transcriptional enhancer.
This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.
PPARG angiopoietin related protein
, angiopoietin-like protein 4
, angiopoietin-related protein 4
, fasting-induced adipose factor
, hepatic angiopoietin-related protein
, hepatic fibrinogen/angiopoietin-related protein
, peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein
, fibrinogen/angiopoietin-related protein
, major histocompatibility complex region NG27
, secreted protein Bk89
, PPARG angiopoietin-related protein
, angiopoietin-like 4
, angiopoietin-like secreted glycoprotein 4
, angiopoietin-related protein 4-like
, angiopoietin-like 4 protein