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Genes coregulated by CDK8 (Montrer CDK8 Protéines)/19 and NFkappaB (Montrer NFKB1 Protéines) include IL8 (Montrer IL8 Protéines), CXCL1 (Montrer CXCL1 Protéines), and CXCL2 (Montrer CXCL2 Protéines).
Moreover, it identified CDK19 and CDK8 (Montrer CDK8 Protéines) to be specifically overexpressed during prostate cancer progression, highlighting their potential as novel therapeutic targets in advanced prostate cancer.
High CDK19 expression is associated with osteosarcoma.
On stimulation of TLR9 (Montrer TLR9 Protéines), CDK8 (Montrer CDK8 Protéines)/19 positively regulates inflammatory gene transcription in cooperation with NF-kappaB (Montrer NFKB1 Protéines) and C/EBPbeta (Montrer CEBPB Protéines).
Data suggest that, during neurogenesis, Mediator complex cyclin-dependent kinases (CDK8, CDK19) interact directly with PRC2 (polycomb repressive complex 2) subunit EZH2 (enhancer of zeste homolog 2), as well as SUZ12 (suppressor of zeste 12 homolog).
Mediator-associated kinases CDK8 (Montrer CDK8 Protéines) and CDK19 restrain increased activation of key super-enhancer-associated genes in acute myeloid leukaemia (AML (Montrer RUNX1 Protéines)) cells
Microarrays identified target genes for each CDK (Montrer CDK4 Protéines), and we selected six genes: two target genes of CDK8 (Montrer CDK8 Protéines), two target genes of CDK19 and two genes that were targets for both.
CDK8 (Montrer CDK8 Protéines) and CDK19, individually interact with PRMT5 (Montrer PRMT5 Protéines) and WDR77 (Montrer WDR77 Protéines), and their interactions with PRMT5 (Montrer PRMT5 Protéines) cause transcriptional repression of C/EBPbeta (Montrer CEBPB Protéines) target genes.
This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex.
CDC2-related protein kinase 6
, CDK8-like cyclin-dependent kinase
, cell division cycle 2-like 6 (CDK8-like)
, cell division cycle 2-like protein kinase 6
, cell division protein kinase 19
, cyclin dependent kinase 19 variant 2
, cyclin-dependent kinase (CDC2-like) 11
, cyclin-dependent kinase 11
, death-preventing kinase
, cyclin-dependent kinase 8