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anti-Mouse (Murine) CLOCK Anticorps:
anti-Rat (Rattus) CLOCK Anticorps:
anti-Human CLOCK Anticorps:
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Human Polyclonal CLOCK Primary Antibody pour IHC (p), ELISA - ABIN543943
Marino, Holt, Chen, Davis: Shift work, hCLOCK T3111C polymorphism, and endometriosis risk. dans Epidemiology (Cambridge, Mass.) 2008
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Human Polyclonal CLOCK Primary Antibody pour ChIP, WB - ABIN151057
Jin, Shearman, Weaver, Zylka, de Vries, Reppert: A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. dans Cell 1999
Show all 6 Pubmed References
Human Monoclonal CLOCK Primary Antibody pour ICC, ELISA - ABIN969059
Lee, Paik, Kang, Lim, Kim: Allelic variants interaction of CLOCK gene and G-protein beta3 subunit gene with diurnal preference. dans Chronobiology international 2007
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Human Polyclonal CLOCK Primary Antibody pour ELISA, WB - ABIN564129
Kalamvoki, Roizman: Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression. dans Proceedings of the National Academy of Sciences of the United States of America 2010
Polyclonal CLOCK Primary Antibody pour ChIP, IP - ABIN540419
Shearman, Weaver: Photic induction of Period gene expression is reduced in Clock mutant mice. dans Neuroreport 1999
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Human Polyclonal CLOCK Primary Antibody pour IHC - ABIN965906
Steeves, King, Zhao, Sangoram, Du, Bowcock, Moore, Takahashi: Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei. dans Genomics 1999
Show all 9 Pubmed References
Data suggest that the clock genes PERIOD and TIMELESS in peripheral clocks show reduction in both expression level and rhythmicity with age.
Spliceosome factors target tim mRNA to control clock protein accumulation and circadian behavior in Drosophila.
In vivo functional characterization of PER O-GlcNAcylation sites indicates that O-GlcNAcylation at PER(S942) reduces interactions between PER and CLOCK (CLK), the key transcriptional activator of clock-controlled genes
experiments define the genetic architecture required to initiate circadian clock function in Drosophila, reveal mechanisms governing circadian activator stability that are conserved in perhaps all eukaryotes, and suggest that Clk, cyc, and cry expression is sufficient to drive clock expression in naive cells
propose that the dCLK/CYC-controlled TTFL operates differently in subsets of pacemaker neurons, which may contribute to their specific functions
ClkAR mutants showed significantly faster age-related locomotor deficits. Accelerated locomotor decline of the ClkAR mutant required expression of the PDF receptor and correlated to an apparent loss of dopaminergic neurons in the brain
Here we demonstrate that the transcription factor CLOCKWORK ORANGE (CWO) antagonizes CLK-CYC E-box binding, thus enhancing the removal of CLK-CYC from E-boxes to maintain transcriptional repression. This process requires PER, which suggests that PER-TIM and CWO cooperate to maintain a transcriptionally repressed state by removing CLK-CYC from E-boxes
these results demonstrate a key role of Clk post-transcriptional control in stabilizing circadian transcription.
Our findings suggest a novel role for clock protein phosphorylation in governing the relative strengths of entraining modalities by adjusting the dynamics of circadian gene expression.
These results demonstrate that CLK phosphorylation influences the circadian period by regulating CLK activity and progression through the feedback loop.
Computational dissection of CLK/CYC context-specific binding sites reveals sequence motifs for putative partner factors, which are predictive for individual binding sites
usp8 loss of function (RNAi) or expression of a dominant-negative form of the protein (USP8-DN) enhances CLK/CYC transcriptional activity and alters fly locomotor activity rhythms
CLK has specific targets in different tissues, implying that important CLK partner proteins and/or mechanisms contribute to gene-specific and tissue-specific regulation
CTRIP destabilizes CLK protein in a PER-independent manner and helps degradation of phosphorylated PER and TIM in the morning
dPER(DeltaCBD) does not provoke the daily hyperphosphorylation of dCLOCK, indicating that direct interactions between dPER and dCLOCK are necessary for the dCLOCK phosphorylation
findings show that Clk and cyc act during starvation to modulate the conflict of whether flies sleep or search for food
Here we examined the consequences of loss of clock function on reproductive fitness in Drosophila melanogaster with mutated period (per(0)), timeless (tim(0)), cycle (cyc(0)), and Clock (Clk(Jrk)) genes
dCLK levels are critical in mediating the direct photostimulation of locomotor activity in Drosophila.
Stress response genes protect against lethal effects of sleep deprivation in Drosophila
role for VRI in the rhythmic repression of output genes that cycle in phase with Clk
Data suggest that Clock1a coordinates mesoderm development and primitive hematopoiesis in embryos by up-regulating Nodal-Smad3 signaling; Clock1a alterations produce embryonic defects with shortened body length, lack of ventral tail fin, or partial defect of the eyes; Clock1a activates Smad3a promoter via its E-box1 element. (Clock1a = clock circadian regulator a; Nodal = nodal modulator 1; Smad3a = SMAD family member 3a)
effect of CRY in repressing transcription mediated by CLOCK-BMAL heterodimer
zCRY and zPER2 regulate the sub-cellular distributions of zCLOCK.
Clock plays important roles in regulating the circadian rhythms in photoreceptor cells
endogenous CLOCK is essential for the transcriptional regulation of period1 in the embryo
Clock is a DENR target in mouse circadian timekeeping
identified a new protein-protein interaction mechanism in which CLOCK can directly regulate cell metabolism via the mitochondrial membrane transporter SLC25A10.
the Bmal1 and Per2 rhythms in the SCN are dissociable and likely regulated by distinct circadian oscillators. Bmal1 is the component of a Bmal1/REV-ERBa/ROR loop and Per2 a Per/Cry/BMAL1/CLOCK loop.
mouse primary-cultured urothelial cells were derived from wild-type and Clock mutant mice (Clock(Delta19/Delta19) ), presenting a nocturia phenotype
The findings demonstrate that nucleus accumbens excitatory signaling via Gria1 expression is integral to the effects of Clock gene disruption on manic-like behaviors.
Study provides evidence that sensation of bladder fullness (SBF) may have a circadian rhythm, which is created by functional circadian changes of Piezo1 and TRPV4 being controlled by clock genes to be active during wakefulness and inactive during sleep. Abnormalities of clock genes disrupt SBF, and induce nocturia.
Clock inhibits adipogenic differentiation of preadipocytes via GILZ.
The predicted CLOCK regulated miRNAs at two time points participated in extremely diverse pathways. The study validated nine miRNAs (miR-125a-3p, miR-144, miR-199a-5p, miR-199b*, miR-200a, miR-200b, miR-203, miR-449a, and miR-96), which were involved in the same signaling pathway-hippo signaling pathway.
Together these data indicate that NRF2 and clock comprise an interlocking loop that integrates cellular redox signals into tissue-specific circadian timekeeping.
Ovarian hormones protect female ClockDelta19/Delta19 mice from the development of age-dependent cardiomyopathy even though Clock function is disturbed.
The authors demonstrated here that Clock knockout mice resisted chemical carcinogen-induced tumorigenesis by suppressing epidermal growth factor (EGF) receptor-mediated proliferation signals.
Data show that differentially expressed in chondrocytes 1 protein (DEC1) and circadian locomoter output cycles kaput protein (CLOCK) bound to E-boxes in the beta1 subunit of the Na(+)/K(+)-ATPase (ATP1B1) promoter and suppressed the expression of ATP1B1.
HNF4A strongly transrepresses the transcriptional activity of the CLOCK:BMAL1 heterodimer.
Carcinogenic exposure decreased BMAL1 and CRYI- expression in the skin, CLOCK expression was upregulated and CRYl downregulated in tumor compared to normal skin. BMAL1 expression increased under disrupted light regimen; melatonin treatment affected CLOCK expression in tumors and CRYI in skin at the carcinogens application sites.
CLOCK phosphorylation by AKT on Ser-845 regulates its nuclear translocation and the expression levels of certain core circadian genes in insulin-sensitive tissues.
The expression of Epcam mRNA, which is a functional marker of potential hepatic stem-like cells, was controlled by LEF1, which was regulated by CLOCK.
Results indicate that circadian locomotor output cycles kaput protein (CLOCK) overexpression triggers the formation of atherosclerotic plaques by directly upregulating plasminogen activator inhibitor 1 (PAI-1) expression.
Low expression of CLOCK protein is associated with kidney tumor.
Clock:BMAL1 promotes a transcriptionally permissive chromatin landscape that primes its target genes for transcription activation rather than directly activating transcription. Environmental or pathological conditions can reprogram the rhythmic expression of clock-controlled genes.
PML mediates the binding of PER2 to BMAL1 in the BMAL1/CLOCK heterodimer and is an important component in the organization of a functional clock complex in the nucleus.
The aim of this study was to investigate, in fibroblasts from genetic Parkinson's disease patients carrying parkin mutations, the interplay between mitochondrial bioenergetics and the cell autonomous circadian clock.
Eight CLOCK SNPs are associated with ADHD risk in Brazilian population.
Loss of protective endothelial CLOCK expression aggravates TGF-beta/ROCK1-modulated endothelial to mesenchymal transition progression, which contributes to the vulnerability of human carotid plaque.
the messenger RNA expression of brain and muscle ARNT-like 1 (BMAL1) and circadian locomotor output cycles kaput (CLOCK) genes is altered by low doses (5 mJ/cm(2) ) of ultraviolet B in the immortalized HaCat human keratinocyte cell line.
The frequency of the TT-genotype and 3111T-allele of the Clock 3111T/C gene polymorphic marker in the Caucasian women with insomnia is higher as compared to control.
We found a significant association with CLOCK rs12649507 and cluster headache
In patients with insomnia, significantly higher levels of melatonin in the early morning hours were found in carriers of the CLOCK TT genotype in comparison with carriers of the minor C allele.
our present research illustrates a novel insight into the circadian clock proteins, CLOCK and BMAL1, which can promote the proliferation, migration, and invasion of cancer cells by affecting the formation of F-actin.
Basal and insulin-stimulated glucose uptake were significantly reduced upon CLOCK depletion. The findings suggest an essential role for the circadian coordination of skeletal muscle glucose homeostasis and lipid metabolism in humans.
The antidepressants efficacy of subjects with rs11932595 AA genotype was significantly higher than those with GG+GA genotypes (p = 0.035). But this p-value was not significant after false discovery rate (FDR) adjustment.
The proliferation of cells significantly decreased after the expression of CLOCK was knocked down in HepG2 cells.
The present study confirmed that circadian dysfunction is associated with the risk of PD in a Chinese population at the genetic level and provided a potential genetic locus related to PD and CLOCK rs1801260 polymorphism is associated with susceptibility to Parkinson's Disease.
The CLOCK SNP may affect daytime gastric motility less than food stimulation.
Significant associations for polymorphisms in CLOCK, NPSR1 and SLC6A3 with traffic crash parameters in professional bus drivers were found.
As a novel CLOCK-dependent diurnal gene, TIMP3 inhibits the expression of inflammatory cytokines that are up-regulated by UV irradiation in human keratinocytes.
the CLOCK gene polymorphism is one of factors determining elastic properties of vascular wall
Rhythmic luciferase activity from clock gene luciferase reporter cells lines was used to test the effect of p38 MAPK inhibition on clock properties as determined using the damped sine fit and Levenberg-Marquardt algorithm.Glioma treatment with p38 MAPK inhibitors may be more effective and less toxic if administered at the appropriate time of the day.
data suggest that SNP variability in the CLOCK gene for rs6850524 and rs11932595 is associated with idiopathic recurrent spontaneous abortion in pregnancies from Slovenia and Serbia
Results indicated that inhibiting the circadian gene Clock expression can reverse the cisplatin resistance of ovarian cancer SKOV3/DDP cell lines by affecting the protein expression of drug resistance genes during which autophagy plays an important role.
the second half of the photolyase homology region (PHR) of CRY is important for repression through facilitating interaction with CLOCK
This gene product regulates circadian rhythm and metabolism. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone acetyltransferase. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.
, clock homolog (mouse)
, clock homolog
, circadian locomoter output cycles protein kaput
, circadian locomoter output cycles protein kaput-like
, circadian locomoter output cycles kaput
, circadian locomoter output cycles kaput protein
, class E basic helix-loop-helix protein 8
, circadian rhythmicity protein CLOCK