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anti-Mouse (Murine) CTGF Anticorps:
anti-Human CTGF Anticorps:
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Human Polyclonal CTGF Primary Antibody pour IHC (p), WB - ABIN3042771
Li, Zhang, Wang, Zheng, Chen: Nicousamide blocks the effects of advanced glycation end products on renal cells. dans European journal of pharmacology 2012
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Human Polyclonal CTGF Primary Antibody pour ICC, IF - ABIN152147
Alfaro, Deskins, Wallus, DasGupta, Davidson, Nanney, A Guney, Gannon, Young: A physiological role for connective tissue growth factor in early wound healing. dans Laboratory investigation; a journal of technical methods and pathology 2012
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Human Polyclonal CTGF Primary Antibody pour IF (p), IHC (p) - ABIN672636
Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats. dans International journal of clinical and experimental pathology 2014
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Polyclonal CTGF Primary Antibody pour WB - ABIN540825
Igarashi, Okochi, Bradham, Grotendorst: Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. dans Molecular biology of the cell 1993
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Human Polyclonal CTGF Primary Antibody pour IHC, WB - ABIN3016900
Zheng, Guan, Jia, Wang, Pang, Lv, Xiao, Wang, Zhang, Xue: The coordinated roles of miR-26a and miR-30c in regulating TGFβ1-induced epithelial-to-mesenchymal transition in diabetic nephropathy. dans Scientific reports 2018
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Human Polyclonal CTGF Primary Antibody pour IHC, WB - ABIN6670448
: Retracted: 'Anti-fibrotic actions of Ghrelin by inhibition of the NADPH oxidase-ROS signaling pathway' by Qian Wang, Xin Sui, Rui Chen, Peiyong Ma, Tao Ding, Dianjun Sui, and Ping Yang. dans Clinical and experimental pharmacology & physiology 2018
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Human Polyclonal CTGF Primary Antibody pour ELISA, WB - ABIN2473120
Sánchez de la Muela, Zudaire, Robles, Rosell, Aguera, De Castro, Isa, Berián: [Survival analysis in renal cell carcinoma with invasion of the vena cava]. dans Actas urologicas españolas 1991
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Human Polyclonal CTGF Primary Antibody pour Func, IF - ABIN2473119
Moussad, Brigstock: Connective tissue growth factor: what's in a name? dans Molecular genetics and metabolism 2000
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Human Monoclonal CTGF Primary Antibody pour IHC, WB - ABIN2718889
Santolla, Lappano, Cirillo, Rigiracciolo, Sebastiani, Abonante, Tassone, Tagliaferri, Di Martino, Maggiolini, Vivacqua: miR-221 stimulates breast cancer cells and cancer-associated fibroblasts (CAFs) through selective interference with the A20/c-Rel/CTGF signaling. dans Journal of experimental & clinical cancer research : CR 2018
Human Polyclonal CTGF Primary Antibody pour IHC, WB - ABIN6139189
Xiao, Ye, Zhou, Huang, Liu, Huang, Zhu, Wu, Zhang, Cai: Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-β/Smads signaling pathway. dans Archives of biochemistry and biophysics 2018
our data identify tumor cell-derived CTGF as a keystone in the hepatocellular carcinoma (HCC) microenvironment, activating nearby Hepatic stellate cells (HSC) that transmit progrowth signals to HCC cells, and this interaction is susceptible to inhibition by an anti-CTGF antibody
High CTGF expression is associated with peritoneal fibrosis.
Secretion of CCN2 by cardiomyocytes is not pro-fibrotic, while fibroblast-derived CCN2 can modulate fibrosis in the heart. In conclusion we found that cardiomyocyte-derived CCN2 is dispensable for cardiac fibrosis, while inhibiting CCN2 induction in activated fibroblasts is sufficient to abrogate the cardiac fibrotic response to angiotensin II
results show that the myofibers are critical mediators of the deleterious effects associated with CTGF in Muscular dystrophy and acutely injured skeletal muscle.
EGFR regulates CCN2 fibrotic signalling in the kidney.
miR-18a was decreased during lung fibrosis in vitro and in vivo, as well as in patients with IPF. Moreover, knockdown of miR-18a led to fibrogenesis in lung fibroblasts, whereas enhanced expression of miR-18a attenuated TGF-beta1-induced lung fibrosis by directly targeting the regulation of connecting tissue growth factor.
we also found that CTGF/CCN2 is expressed in astrocytes and neurons, predominantly in dorsal areas of spinal cord from symptomatic hSOD1G93A mice. Together, these results reveal that CTGF/CCN2 might be a novel therapeutic target to ameliorate symptoms and improve the quality of life of ALS patients.
Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis.
These results reveal a novel mechanism of macrophage migration into glomeruli with nephritis mediated by connective tissue growth factor derived from mesangial cells.
miR-26b-5p interacted with 3'UTRs of Col1a2 and CTGF, and circ_000203 could block the interactions of miR-26b-5p and 3'UTRs of Col1a2 and CTGF.
early myocardial CTGF mRNA expression (six hours) after Ang-II exposure is likely dependent on latent TGF-beta activation via the canonical Smad-dependent pathway in resident cardiac cells.
These results indicate that the hepatocytic expression of TGF-beta and CTGF is mediated by Wnt signalling in Schistosoma japonicum infection.
Data (including data from studies using transgenic mice) suggest that Ctgf secreted from vascular endothelium in pancreas plays critical role in up-regulation of insulin secretion in pancreatic beta-cells during pregnancy; here, pregnant mice with global Ctgf haplo-insufficiency (heterozygous for loss-of-function mutation) (a) exhibit impairment in maternal beta-cell proliferation and (b) develop gestational diabetes.
The data demonstrate that MMP13 and CTGF play a crucial role in modulation of fibrogenic mediators while promoting hepatic fibrogenesis.
p-SMAD2/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 induced CTGF exp p-SMAD2/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 induced CTGF expression during tooth development.
Ctgf is the direct target gene of SOX9 in chondrocytes and nucleus pulposus cells.
As shown in mouse model of kidney fibrosis CTGF is significantly involved in fibrosis-associated renal lymphangiogenesis through regulation of, and direct interaction with, VEGF-C.
CTGF and BMP2 are induced following myocardial ischemia in mice and humans.
this study suggested that CTGF antibody protected podocytes against injury in DN mice by reducing beta-catenin overexpression and preventing podocyte EMT, which might provide new insight into the mechanism of CTGF inhibition in the treatment of DN.
LPA-LPA1 signaling initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.
ADAM17/EGFR-dependent ERK activation mediated thrombin-stimulated CTGF expression in human lung fibroblasts.
TGF-beta 1/CTGF based on the p38 MAPK signaling pathway play an important role in the occurance and development of hypertrophy of human lumbar ligamentum flavum.
connective tissue growth factor (CTGF) was the target gene regulated by miR-133b.
Here it is demonstrated that S1P activates YAP and that the S1P receptor 2 (S1PR2/S1P2) mediates S1P-induced YAP activation in both human and mouse hepatocellular carcinoma (HCC) cells. S1P promotes YAP-mediated upregulation of cysteine-rich protein 61 and connective tissue growth factor (CTGF), and stimulates HCC cell proliferation
Results provide new insights into the cross-talk among different cell types in the tumor microenvironment and suggest cancer-associated fibroblasts (CAFs) play an unappreciated role in melanoma metastasis and progression by being essential for tumor neovascularization via the production of CCN2.
In conclusion, circulating levels of CCN2 measured in the acute phase of STEMI were not associated with final infarct size, left ventricular function or new clinical events.
Inhibiting CTGF could improve inflammatory response.
miR-145 suppressed the progression of AAD [acute aortic dissection] by targeting CTGF [connective tissue growth factor], suggesting that a miR-145/CTGF axis may provide a potential therapeutic target for AAD.
tumor-secreted CTGF/VEGFA alone is sufficient to activate paired mammary fibroblasts from the same patient via ROCK1 and JunB signaling.
CCN2 is synthesized and secreted as a preproprotein that is autoinhibited by its two N-terminal domains and requires proteolytic processing and homodimerization to become fully biologically active.
In regards to extracellular matrix remodelling, treprostinil significantly reduced PDGF-BB-TGF-beta1-CTGF induced synthesis and deposition of collagen type I and fibronectin, in a cAMP sensitive manner
Curcumin can suppress TGF-beta1-induced CTGF expression in human gingival fibroblasts through the interruption of Smad2 signaling.
a significant negative correlation between hsamiR1455p and CTGF in ovarian cancer development, is reported.
These results suggest that Angiotensin II induces CTGF expression and extracellular matrix accumulation through a special TGF-beta-independent interaction between the NF-kappaB and Smad2/3 signals elicited by the AT1/PKCalpha/p38 MAPK pathway.
Connective tissue growth factor (CTGF), a matricellular protein, combines with TGF-beta in the pathomechanism of many fibrotic disorders. This interaction takes place in asthma as well, as fibroblast to myofibroblast transition contributes to bronchial wall remodelling in persistent asthma.
Study describes the molecular and biological characteristics of CTGF, its regulation and various functions in the spectrum of development and regeneration to fibrosis. [review]
This work indicates that NELL-1, HMGB1, and CCN2 might enhance bone defect healing via the recruitment of endogenous cells and induction of vascularization and act via different processes than BMP2.
TRAF1, CTGF, and CX3CL1 genes are hypomethylated in osteoarthritis
Down-regulation of CTGF could markly decrease proliferation.
Bovine CCN2 exhibits unique expression patterns during preimplantation development, and is required for the proper expression of key regulatory genes in bovine blastocysts.
Results confirm the prodevelopmental actions of activin A and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF were inhibitory to development.
The results indicate that CTGF suppresses the synthesis of biglycan but newly induced that of decorin in the cells when the cell density is low.
Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
this study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.
CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development
Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2-, GFAP-and GFAP/Nestin-positive cells, activated p44/42 signaling, and upregulated fibronectin. In human glioma cells, it induced GFAP and nestin.
Data show that connective-tissue growth factor regulates signalling through the Wnt pathway, in accord with its ability to bind to the Wnt co-receptor LDL receptor-related protein 6 (LRP6).
These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.
A significant increase in TGF-beta1 and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.
Stretch is an important primary trigger for CTGF-induction in the overloaded heart.
Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.
TGF-beta1 can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.
Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.
CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.
Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.
CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.
CTGF level was not altered in model of obliterative bronchiolitis.
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
CCN family member 2
, Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
, fibroblast inducible secreated protein
, fibroblast inducible secreted protein
, hypertrophic chondrocyte-specific gene product 24
, hypertrophic chondrocyte-specific protein 24
, IGF-binding protein 8
, insulin-like growth factor-binding protein 8
, connective tissue growth-related protein
, connective tissue growth factor
, connective tissue growth factor XCTGF
, Connective tissue growth factor
, connective tissue growth factor-like