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These results reveal a novel mechanism of macrophage migration into glomeruli with nephritis mediated by connective tissue growth factor derived from mesangial cells.
miR (Montrer MLXIP Protéines)-26b-5p interacted with 3'UTRs of Col1a2 (Montrer COL1A2 Protéines) and CTGF, and circ_000203 could block the interactions of miR (Montrer MLXIP Protéines)-26b-5p and 3'UTRs of Col1a2 (Montrer COL1A2 Protéines) and CTGF.
early myocardial CTGF mRNA expression (six hours) after Ang-II (Montrer AGT Protéines) exposure is likely dependent on latent TGF-beta (Montrer TGFB1 Protéines) activation via the canonical Smad (Montrer SMAD1 Protéines)-dependent pathway in resident cardiac cells.
These results indicate that the hepatocytic expression of TGF-beta (Montrer TGFB1 Protéines) and CTGF is mediated by Wnt (Montrer WNT2 Protéines) signalling in Schistosoma japonicum infection.
Data (including data from studies using transgenic mice) suggest that Ctgf secreted from vascular endothelium in pancreas plays critical role in up-regulation of insulin (Montrer INS Protéines) secretion in pancreatic beta-cells during pregnancy; here, pregnant mice with global Ctgf haplo-insufficiency (heterozygous for loss-of-function mutation) (a) exhibit impairment in maternal beta-cell proliferation and (b) develop gestational diabetes.
The data demonstrate that MMP13 (Montrer MMP13 Protéines) and CTGF play a crucial role in modulation of fibrogenic mediators while promoting hepatic fibrogenesis.
p-SMAD2 (Montrer SMAD2 Protéines)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 (Montrer TGFB1 Protéines) induced CTGF exp p-SMAD2 (Montrer SMAD2 Protéines)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 (Montrer TGFB1 Protéines) induced CTGF expression during tooth development.
Ctgf is the direct target gene of SOX9 (Montrer SOX9 Protéines) in chondrocytes and nucleus pulposus cells.
As shown in mouse model of kidney fibrosis CTGF is significantly involved in fibrosis-associated renal lymphangiog (Montrer VEGFC Protéines)enesis through regulation of, and direct interaction with, VEGF-C.
CTGF and BMP2 (Montrer BMP2 Protéines) are induced following myocardial ischemia in mice and humans.
TRAF1 (Montrer TRAF1 Protéines), CTGF, and CX3CL1 (Montrer CX3CL1 Protéines) genes are hypomethylated in osteoarthritis
Down-regulation of CTGF could markly decrease proliferation.
PVT1 was able to bind and degrade miR26b to promote connective tissue growth factor (CTGF) and angiopoietin 2 (ANGPT2 (Montrer ANGPT2 Protéines)) expression.
CTGF can reduce glycolysis and mitochondrial OXPHOS pathways by increasing mtTFA (Montrer TFAM Protéines) protein degradation and in turn reduces cancer migration and invasion in oral squamous cell carcinoma (OSCC).
Results show that mRNA and serum expression levels of Cyr61 (Montrer CYR61 Protéines), CTGF, and VEGF (Montrer VEGFA Protéines) in muscle tissues of patients with polymyositis (PM)/dermatomyositis (DM). These data suggest that these genes may be involved in the pathogenesis mainly by affecting the formation of blood vessels and promoting inflammatory response.
This study study discovered a positive feedback loop between CTGF and CCL18 (Montrer CCL18 Protéines) in hepatocellular carcinoma metastasis.
Serum connective tissue growth factor (CTGF) is a promising diagnostic biomarker for rheumatoid arthritis (RA).
Connective tissue growth factor (CTGF) is an important mediator of renal allograft fibrosis, and urinary CTGF (CTGFu) levels correlate with the development of allograft interstitial fibrosis. We evaluated the predictive value of CTGF protein expression in 160 kidney transplant recipients with paired protocol biopsies at 3 months and 5 years after transplantation.
Lymphangiogenesis during tubulointerstitial fibrosis to be associated with increased expression of CTGF and VEGF-C (Montrer VEGFC Protéines) in human obstructed nephropathy as well as in diabetic kidney disease. vitro, CTGF induced VEGF-C (Montrer VEGFC Protéines) production in HK-2 (Montrer HK2 Protéines) cells, while CTGF siRNA suppressed transforming growth factor beta1-induced VEGF-C (Montrer VEGFC Protéines) upregulation.
miR132 may target CTGF in regulating fibrosis in Ang (Montrer ANG Protéines) IItreated cardiac fibroblasts.
Results confirm the prodevelopmental actions of activin A (Montrer INHBA Protéines) and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF (Montrer HGF Protéines) were inhibitory to development.
The results indicate that CTGF suppresses the synthesis of biglycan (Montrer BGN Protéines) but newly induced that of decorin (Montrer DCN Protéines) in the cells when the cell density is low.
Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
this study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.
CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development
Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2 (Montrer SOX2 Protéines)-, GFAP (Montrer GFAP Protéines)-and GFAP (Montrer GFAP Protéines)/Nestin (Montrer NES Protéines)-positive cells, activated p44 (Montrer GTF2H2 Protéines)/42 signaling, and upregulated fibronectin (Montrer FN1 Protéines). In human glioma cells, it induced GFAP (Montrer GFAP Protéines) and nestin (Montrer NES Protéines).
Data show that connective-tissue growth factor regulates signalling through the Wnt (Montrer WNT2 Protéines) pathway, in accord with its ability to bind to the Wnt (Montrer WNT2 Protéines) co-receptor LDL receptor (Montrer LDLR Protéines)-related protein 6 (LRP6 (Montrer LRP6 Protéines)).
These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.
A significant increase in TGF-beta1 (Montrer TGFB1 Protéines) and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.
Stretch is an important primary trigger for CTGF-induction in the overloaded heart.
Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.
TGF-beta1 (Montrer TGFB1 Protéines) can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.
Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.
CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.
Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.
CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.
CTGF level was not altered in model of obliterative bronchiolitis.
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
CCN family member 2
, Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
, fibroblast inducible secreated protein
, fibroblast inducible secreted protein
, hypertrophic chondrocyte-specific gene product 24
, hypertrophic chondrocyte-specific protein 24
, IGF-binding protein 8
, insulin-like growth factor-binding protein 8
, connective tissue growth-related protein
, connective tissue growth factor
, connective tissue growth factor XCTGF
, Connective tissue growth factor
, connective tissue growth factor-like