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anti-Mouse (Murine) FDFT1 Anticorps:
anti-Rat (Rattus) FDFT1 Anticorps:
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Human Polyclonal FDFT1 Primary Antibody pour IHC (p), WB - ABIN389052
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... dans Proceedings of the National Academy of Sciences of the United States of America 2002
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Human Polyclonal FDFT1 Primary Antibody pour IHC (p), ELISA - ABIN4369832
Jiang, McKenzie, Conrad, Shechter: Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase. dans The Journal of biological chemistry 1993
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Cow (Bovine) Polyclonal FDFT1 Primary Antibody pour WB - ABIN4271866
Healey, Collier, Griffin, Schuberth, Sandra, Smith, Mahan, Dieuzy-Labaye, Sheldon: Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis. dans Journal of immunology (Baltimore, Md. : 1950) 2016
Human Polyclonal FDFT1 Primary Antibody pour ICC, IF - ABIN4311300
Wu, Hsu, Chen, Yu, Chang, Tai, Liu, Su, Chang, Yu: Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas. dans Molecular & cellular proteomics : MCP 2010
This study demonistrated that fdft1 is regulate the neuronal cholesterol synthesis during neurite outgrowth.
Result provides the first in vivo evidence that SS plays a regulatory role in cholesterol metabolism through modulation of HMG-CoA reductase (Montrer HMGCR Anticorps) activity and cholesterol biosynthesis.
VEGF (Montrer VEGFA Anticorps) expression, APOPTOSIS, AND ANGIOGENESIS in squalene synthase -ablated neural stem cells wERE strongly upregulated
The results indicate that the ennea-peptide CLSPHSMFC, tetra-peptides SMFC, CKTE, and WHQW can effectively inhibit Squalene Synthase activities (IC50 values equal to 64, 76, 87, and 90 muM, respectively)
The minor allele in FDFT1 was associated with advanced fibrosis in the non-steatotic but not in the steatotic subgroup in patients with chronic hepatitis C.
Up-regulation of SQS promotes metastasis of lung cancer by enhancing tumor necrosis factor-alpha receptor (Montrer TNFRSF1A Anticorps) 1 and nuclear factor-kappaB activation and matrix metallopeptidase (Montrer ECEL1 Anticorps) 1 expression.
Several critical residues that are involved in binding of NADPH (Montrer NQO1 Anticorps) have been identified in the active site of squalene synthase.
HCV infection increases FDFT1 protein level but not FDFT1 mRNA level.
ABHD5 (Montrer ABHD5 Anticorps), PGRMC1 (Montrer PGRMC1 Anticorps) and SQS are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically BCC with clear cell features.
FDFT1 and its encoded enzyme, squalene synthase, may play an important role in prostate cancer development and its aggressive phenotypes.
CTSB (Montrer CTSB Anticorps) and FDFT1 are excluded as candidates for keratolytic winter erythema
NASH (Montrer SAMSN1 Anticorps) is intimately related to fibrosis progression, the FDFT1 SNP is a good candidate for a link with inflammation and fibrosis.
In multivariate models adjusted for age, body mass index, diabetes, waist/hip ratios, and levels of glycated hemoglobin (Montrer HBB Anticorps), the NAFLD (Montrer TSC2 Anticorps) activity score was associated with the SNP rs2645424 on chromosome 8 in farnesyl diphosphate farnesyl transferase 1 (FDFT1)
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.
farnesyl-diphosphate farnesyltransferase 1
, squalene synthase
, Squalene synthetase
, FPP:FPP farnesyltransferase
, squalene synthase-like
, farnesyl-diphosphate farnesyltransferase
, squalene synthetase
, farnesyl diphosphate farnesyltransferase
, presqualene-di-diphosphate synthase