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This study demonistrated that fdft1 is regulate the neuronal cholesterol synthesis during neurite outgrowth.
Result provides the first in vivo evidence that SS plays a regulatory role in cholesterol metabolism through modulation of HMG-CoA reductase (Montrer HMGCR Protéines) activity and cholesterol biosynthesis.
VEGF (Montrer VEGFA Protéines) expression, APOPTOSIS, AND ANGIOGENESIS in squalene synthase -ablated neural stem cells wERE strongly upregulated
The results indicate that the ennea-peptide CLSPHSMFC, tetra-peptides SMFC, CKTE, and WHQW can effectively inhibit Squalene Synthase activities (IC50 values equal to 64, 76, 87, and 90 muM, respectively)
The minor allele in FDFT1 was associated with advanced fibrosis in the non-steatotic but not in the steatotic subgroup in patients with chronic hepatitis C.
Up-regulation of SQS promotes metastasis of lung cancer by enhancing tumor necrosis factor-alpha receptor (Montrer TNFRSF1A Protéines) 1 and nuclear factor-kappaB activation and matrix metallopeptidase (Montrer ECEL1 Protéines) 1 expression.
Several critical residues that are involved in binding of NADPH (Montrer NQO1 Protéines) have been identified in the active site of squalene synthase.
HCV infection increases FDFT1 protein level but not FDFT1 mRNA level.
ABHD5 (Montrer ABHD5 Protéines), PGRMC1 (Montrer PGRMC1 Protéines) and SQS are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically BCC with clear cell features.
FDFT1 and its encoded enzyme, squalene synthase, may play an important role in prostate cancer development and its aggressive phenotypes.
CTSB (Montrer CTSB Protéines) and FDFT1 are excluded as candidates for keratolytic winter erythema
NASH (Montrer SAMSN1 Protéines) is intimately related to fibrosis progression, the FDFT1 SNP is a good candidate for a link with inflammation and fibrosis.
In multivariate models adjusted for age, body mass index, diabetes, waist/hip ratios, and levels of glycated hemoglobin (Montrer HBB Protéines), the NAFLD activity score was associated with the SNP rs2645424 on chromosome 8 in farnesyl diphosphate farnesyl transferase 1 (FDFT1)
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.
farnesyl-diphosphate farnesyltransferase 1
, squalene synthase
, Squalene synthetase
, FPP:FPP farnesyltransferase
, squalene synthase-like
, farnesyl-diphosphate farnesyltransferase
, squalene synthetase
, farnesyl diphosphate farnesyltransferase
, presqualene-di-diphosphate synthase