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EAF1 (239-268) and TAF7 (205-235) peptide interactions were both mapped to the same groove formed by H3 and H4 helices of MED26 N-terminal domain.
the MED26-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes
MED26 can function as a molecular switch that interacts first with TFIID in the Pol II initiation complex and then exchanges TFIID for complexes containing ELL/EAF and P-TEFb to facilitate transition of Pol II into the elongation stage of transcription.
Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation
findings identify MED19/MED26 as a probable composite REST interface in Mediator and further clarify the mechanistic basis by which Mediator facilitates REST-imposed epigenetic restrictions on neuronal gene expression
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
mediator of RNA polymerase II transcription subunit 26
, CRSP complex subunit 7
, mediator complex subunit 26
, activator-recruited cofactor 70 kDa component
, cofactor required for Sp1 transcriptional activation subunit 7
, cofactor required for Sp1 transcriptional activation, subunit 7 (70kD)
, cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa
, transcriptional coactivator CRSP70
, solute carrier family 35, member E1
, CRSP70-like protein