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Human Monoclonal SMARCD3 Primary Antibody pour IF, ELISA - ABIN562916
Flajollet, Lefebvre, Cudejko, Staels, Lefebvre: The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor. dans Molecular and cellular endocrinology 2007
Show all 3 Pubmed References
Human Monoclonal SMARCD3 Primary Antibody pour ELISA, WB - ABIN394383
Watanabe, Ui, Kanno, Ogiwara, Nagase, Kohno, Yasui: SWI/SNF factors required for cellular resistance to DNA damage include ARID1A and ARID1B and show interdependent protein stability. dans Cancer research 2014
Data show that the combination of GATA binding protein 4 (Gata4 (Montrer GATA4 Anticorps)), T-box transcription factor 5 (Tbx5 (Montrer TBX5 Anticorps)) and BRG1-associated factor 60C protein (Baf60c) is sufficient for inducing adipose tissue-derived mesenchymal stem cells (ADMSCs) to form cardiomyocytes.
Inhibition of Wnt5a (Montrer WNT5A Anticorps) by either RNAi knockdown or blocking antibody reversed Smarcd3 -induced epithelial-mesenchymal transition. Thus, Smarcd3 epigenetically regulates epithelial-mesenchymal transition by activating WNT (Montrer WNT2 Anticorps) signaling pathways.
Deptor (Montrer DEPTOR Anticorps) is induced by the Baf60c-Six4 (Montrer SIX4 Anticorps) transcriptional complex and mediates activation of Akt (Montrer AKT1 Anticorps) and glycolytic metabolism by Baf60c in a cell-autonomous manner
BAF60c promotes lipogenesis in vivo and increases triglyceride levels, demonstrating its role in metabolic adaption to activate the lipogenic program in response to feeding and insulin (Montrer INS Anticorps).
Data show a combination of only five genes (-BCL6 (Montrer BCL6 Anticorps), T (BRACHYURY (Montrer TBX1 Anticorps)), c-MYC (Montrer MYC Anticorps), MITF (Montrer MITF Anticorps) and BAF60C (SMARCD3) rapidly and efficiently convert postnatal chorion and decidual cells into chondrocytes.
BAF6 (Montrer MYOD1 Anticorps)0c phosphory (Montrer SMARCA1 Anticorps)lati (Montrer SNRPA Anticorps)on on a conserved threonine is the signal that promotes inc (Montrer MYOD1 Anticorps)orporation of MyoD-BAF60c into a Brg1-based SWI/SNF complex, which remodels the chromatin & activates transcription of MyoD-target genes.
GTNB (Montrer DTNB Anticorps) directs cardiogenesis from human embryonic stem cells and induces correct cardiac development.
BAF60c represents a new coregulator that constitutes an important anchoring point by which the SWI (Montrer SMARCA1 Anticorps)/SNF (Montrer SNRPA Anticorps) complex is recruited to nuclear receptors and other transcription factors
Tat (Montrer TAT Anticorps)-mediated activation of the HIV promoter requires the SWI (Montrer SMARCA1 Anticorps)/SNF (Montrer SNRPA Anticorps) complex in synergy with the coactivator p300 (Montrer EP300 Anticorps).
Baf60c is re-expressed in the Muller glial cells that re-enter the cell cycle after neurotoxic damage
work revealed functional redundancy between Baf60a (Montrer SMARCD1 Anticorps) and Baf60c in maintaining oxidative and glycolytic metabolism in skeletal myofibers and exercise endurance. Unexpectedly, mice lacking these two factors in skeletal muscle were protected from diet-induced and age-associated metabolic disorders. Transcriptional profiling analysis identified the muscle thermogenic gene program and myokine secretion as key pathways that inte
These data suggested that Baf60c plays an important role in cardiomyocyte proliferation in heart development and regeneration. This is the first study indicating that Baf60c contributes to the heart regeneration in vertebrates.
postmitotic expression SOD1G93A mutant gene promotes a FAPS phenotype in C2C12 cells, by upregulating HDAC4 (Montrer HDAC5 Anticorps) protein and preventing the BAF60C-SWI (Montrer SMARCA1 Anticorps)/SNF (Montrer SNRPA Anticorps) complex myogenic commitment
regulates the Nodal/Bone Morphogenetic Protein antagonist Cerberus (Montrer CER1 Anticorps) and the Baf60c/Smarcd3 subunit of the Brg1 (Montrer SMARCA4 Anticorps)/Brm (Montrer SMARCA2 Anticorps)-associated factors (BAF (Montrer BANF1 Anticorps)) chromatin-remodelling complex
Overexpression of transcription factors MYOCD (Montrer MYOCD Anticorps) and SRF alone or in conjunction with Mesp1 (Montrer MESP1 Anticorps) and SMARCD3 enhanced the basal but necessary cardio-inducing effect of the previously reported GATA4 (Montrer GATA4 Anticorps), TBX5 (Montrer TBX5 Anticorps), and MEF2C (Montrer MEF2C Anticorps).
MyoD (Montrer MYOD1 Anticorps) and the SWI (Montrer SMARCA1 Anticorps)/SNF (Montrer SNRPA Anticorps) subunit BAF60c interact on the regulatory elements of MyoD (Montrer MYOD1 Anticorps)-target genes in myoblasts, prior to activation of transcription.
Smarcd3, encoding Baf60c, a subunit of the BAF (Montrer BANF1 Anticorps) complexes, is expressed specifically in the heart and somites in the early mouse embryo
propose a critical role for Baf60c in Notch (Montrer NOTCH1 Anticorps)-dependent transcription and left-right asymmetry
Two highly related subunits of the core SWI (Montrer SMARCA1 Anticorps)/SNF (Montrer SNRPA Anticorps) complex, BAF60c1 and BAF60c2, interact physically with retinoid receptors and are coactivators for retinoic acid receptors.
Smarcd3 regulates the timing of zebrafish myogenesis onset [Smarcd3]
Overexpression of smarcd3b and gata5 in zebrafish results in an enlarged heart, whereas combinatorial loss of cBAF components inhibits cardiac differentiation, demonstrating that Smarcd3b and Gata5 can induce a primitive, progenitor cell-like state.
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3-like
, 60 kDa BRG-1/Brm-associated factor subunit C
, BRG1-associated factor 60C
, SWI/SNF complex 60 kDa subunit C
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
, Swp73-like protein
, chromatin remodeling complex BAF60C subunit
, mammalian chromatin remodeling complex BRG1-associated factor 60C