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anti-Human TEAD4 Anticorps:
anti-Mouse (Murine) TEAD4 Anticorps:
anti-Rat (Rattus) TEAD4 Anticorps:
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Human Monoclonal TEAD4 Primary Antibody pour IP, RNAi - ABIN563135
Benhaddou, Keime, Ye, Morlon, Michel, Jost, Mengus, Davidson: Transcription factor TEAD4 regulates expression of myogenin and the unfolded protein response genes during C2C12 cell differentiation. dans Cell death and differentiation 2012
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Cow (Bovine) Polyclonal TEAD4 Primary Antibody pour IF, WB - ABIN2777935
Appukuttan, McFarland, Davies, Atchaneeyasakul, Zhang, Babra, Pan, Rosenbaum, Acott, Powers, Stout: Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina. dans Investigative ophthalmology & visual science 2007
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Cow (Bovine) Polyclonal TEAD4 Primary Antibody pour IHC, WB - ABIN2780491
Chen, Baty, Maeda, Brooks, Baker, Ueyama, Gursoy, Saba, Salama, London, Stewart: Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation. dans Circulation 2004
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the transcriptional regulators in the Hippo pathway, Tead4 and Yap1 (Montrer YAP1 Anticorps), are required for general vertebrate epimorphic regeneration as well as for organ size control in appendage regeneration
TEAD4, the transcription factor that mediates Hippo-YAP (Montrer YAP1 Anticorps) signalling, undergoes alternative splicing facilitated by the tumour suppressor RBM4 (Montrer RBM4 Anticorps).
Studied the effect of TEAD4 acylation on its interaction with YAP (Montrer YAP1 Anticorps) and TAZ (Montrer TAZ Anticorps); found YAP (Montrer YAP1 Anticorps) and TAZ (Montrer TAZ Anticorps) bind in a similar manner to both acylated and non-acylated TEAD4. Also found TEAD4 acylation significantly enhances its stability.
High TEF3 (Montrer TRIM37 Anticorps) expression is associated with cell cycle progression and angiogenesis in colon cancer.
TEAD1 (Montrer TEAD1 Anticorps) and TEAD4 are oncogenic factors, whose aberrant activation are, in part, mediated by the silence of miR (Montrer MLXIP Anticorps)-377-3p, miR (Montrer MLXIP Anticorps)-1343-3p and miR (Montrer MLXIP Anticorps)-4269.
Osmotic stress promotes TEAD4 cytoplasmic translocation via p38 MAPK (Montrer MAPK14 Anticorps) in a Hippo-independent manner. Stress-induced TEAD inhibition predominates YAP (Montrer YAP1 Anticorps)-activating signals and selectively suppresses YAP (Montrer YAP1 Anticorps)-driven cancer cell growth.
The transcription factor TEAD4 regulates a pro-metastasis transcription program in a YAP (Montrer YAP1 Anticorps)-independent manner in CRC (Montrer CALR Anticorps), thus providing a novel mechanism of TEAD4 transcriptional regulation and its oncogenic role in CRC (Montrer CALR Anticorps), independently of the Hippo pathway.
our work provides a structural basis for understanding the regulatory mechanism of TEAD4-mediated gene transcription
Our results suggest that TEAD4 plays a role in the pathophysiology of atypical teratoid/rhabdoid tumor, which represents a new insight into the biology of this aggressive tumor
It was found that the TEAD4-YAP (Montrer YAP1 Anticorps) complex in the nuclei may be related closely to transcriptions of G1 arrest-related genes.
Collectively, these results indicate that human papillomavirus 16 E6 induces upregulation of APOBEC3B (Montrer APOBEC3B Anticorps) through increased levels of TEADs, highlighting the importance of the TEAD-APOBEC3B (Montrer APOBEC3B Anticorps) axis in carcinogenesis.
TEAD4 mRNA was found to be upregulated between the 16-cell and morula stages, and nuclear localization of the TEAD4 protein was detected at the morula stage, as well as in subsequent developmental stages. TEAD4 downregulation did not affect embryonic development until the blastocyst stage, and TEAD4-downregulated embryos were capable of forming the TE under both 5% and 21% O2 conditions.
AP-1 (Montrer JUN Anticorps)- and TEAD4-associated cis (Montrer CISH Anticorps)-regulatory elements form hubs for multiple signalling-responsive transcription factors and define the cistrome that regulates vascular and hematopoietic development by extrinsic signals.
Data show that TEAD family of transcription factors Tead1 (Montrer TEAD1 Anticorps) and Tead4-regulated gene expression in differentiating primary myoblasts.
Dual-luciferase reporter gene analysis showed that RTEF-1 is a direct target of mir (Montrer MLXIP Anticorps)-125a-5p, which regulates angiogenesis by repressing RTEF-1 expression and modulating eNOS (Montrer NOS3 Anticorps) and VEGF (Montrer VEGFA Anticorps) expression.
TEAD4 establishes the energy homeostasis essential for blastocoel formation.
These results show that RTEF-1-stimulated IGFBP-1 (Montrer IGFBPI Anticorps) expression may be central to the mechanism by which RTEF-1 attenuates blood glucose levels.
Vgll1 (Montrer VGLL1 Anticorps) interacts with TEAD4 in a manner similar to the transcription coactivators, as well as oncogenes YAP (Montrer YAP1 Anticorps) and TAZ (Montrer TAZ Anticorps), despite having a varied primary sequence. Vgll1 (Montrer VGLL1 Anticorps) has the potential to promote cancer progression.
endothelial-specific RTEF-1 overexpressing mice had enhanced angiogenic sprouting and vascular structure remodeling, resulting in the formation of a denser and more highly interconnected superficial capillary plexus
Data suggest that altered subcellular localization of TEAD4 in blastomeres dictates first mammalian cell fate specification.
TEAD factors directly induce Myogenin (Montrer MYOG Anticorps), CDKN1A (Montrer CDKN1A Anticorps) and Caveolin 3 (Montrer CAV3 Anticorps) expression to promote myoblast differentiation.
Gata3 (Montrer GATA3 Anticorps) and Cdx2 (Montrer CDX2 Anticorps) can act in parallel pathways downstream of Tead4 to induce the expression of common and independent targets in the trophoblast lineage, whereas Oct4 (Montrer POU5F1 Anticorps) is required for continued repression of trophoblast fate in the embryonic lineage
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.
TEA domain family member 4
, M-CAT binding factor
, M-CAT-binding factor
, transcriptional enhancer factor TEF-3
, related transcription enhancer factor 1B
, transcription factor 13-like 1
, transcription factor RTEF-1
, transcriptional enhancer factor 1-related
, transcriptional enhancer factor 3
, transcriptional enhancer factor 1-related protein
, ETF-related factor 2
, ETF-related factor-2
, FGF-regulated 19
, TEF-1-related factor 1
, TEF-1-related factor FR-19