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Cow (Bovine) Polyclonal CDON Primary Antibody pour ELISA, ICC - ABIN4297093
Kang, Feinleib, Knox, Ketteringham, Krauss: Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. dans Proceedings of the National Academy of Sciences of the United States of America 2003
Human Polyclonal CDON Primary Antibody pour CyTOF, FACS - ABIN4899986
Cardozo, Sánchez-Arrones, Sandonis, Sánchez-Camacho, Gestri, Wilson, Guerrero, Bovolenta: Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle. dans Nature communications 2015
We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis
CDO (Montrer CDO1 Anticorps) is required for proliferation and survival of lung cancer cells via Hh signaling.
These data support the view that cell-adhesion molecule (Montrer MCAM Anticorps)-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs.
Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer.
Mutations in the CDON cause holoprosencephaly. (Review)
We found that CDON is overexpressed in prostate cancer
CDON must associate with both ligand and other hedgehog (Montrer SHH Anticorps)-receptor components, particularly PTCH1 (Montrer PTCH1 Anticorps), for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly.
Hedgehog (Montrer SHH Anticorps) proteins interact with cell adhesion molecule (Montrer MCAM Anticorps), down-regulated by oncogenes (CDO (Montrer CDO1 Anticorps)) and brother of CDO (BOC (Montrer BOC Anticorps)) in a conserved manner
CDO (Montrer CDO1 Anticorps) and BOC (Montrer BOC Anticorps) play a role in differentiation of cells in the skeletal muscle lineage
CDO (Montrer CDO1 Anticorps) and BOC (Montrer BOC Anticorps) forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact.
Cdon deficiency causes hyperactive Wnt (Montrer WNT2 Anticorps) signaling leading to aberrant intercellular coupling and cardiac fibrosis.
These results support a model whereby mutations in Cdon and prenatal ethanol exposure increase Septo-optic dysplasia risk through spatiotemporal perturbations in Shh (Montrer SHH Anticorps) signaling activity.
Mutation in the Cdon gene is associated with congenital nevus development.
Study assessed the role of the Shh (Montrer SHH Anticorps) receptor Cdon in the development of ventral tegmental area and substantia nigra pars (Montrer EPRS Anticorps) compacta dopamine neurons. Results suggest that Cdon plays an important role in the encoding of diversity within the population of dopamine neurons of the midbrain, influencing both the development of the mesocortical dopamine pathway as well as behavioral outputs that involve this neural circuitry.
Results suggest that a promyogenic cell adhesion molecule (Montrer MCAM Anticorps) Cdo (Montrer CDO1 Anticorps) signaling is critical for Inward rectifier potassium channel Kir2.1 (Montrer KCNJ2 Anticorps) activities in the induction of myogenic differentiation.
PKN2 (Montrer PKN2 Anticorps) formed complexes with Cdo (Montrer CDO1 Anticorps), APPL1 (Montrer APPL1 Anticorps) and AKT (Montrer AKT1 Anticorps) via its C-terminal region and this interaction appeared to be important for induction of AKT (Montrer AKT1 Anticorps) activity as well as myoblast differentiation.
that Cdon participates in oligodendrocyte differentiation and myelination, most likely in the initial stages of development
Suggest that Cdo (Montrer CDO1 Anticorps) is required for the full Shh (Montrer SHH Anticorps) signaling activation to induce efficient dopaminergic neuron neurogenesis.
Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1 (Montrer PTCH1 Anticorps).
Cx43 (Montrer GJA1 Anticorps) physically interacts with Cdo (Montrer CDO1 Anticorps) to form dynamic complexes during myoblast differentiation
Cdon is required to localize N-cadherin (Montrer CDH2 Anticorps) to the cell membrane in migratory neural crest cells for directed migration.
In the developing optic vesicle, Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hedgehog (Montrer SHH Anticorps) protein, thereby limiting its dispersion.
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis.
, cell adhesion molecule-related/down-regulated by oncogenes
, surface glycoprotein, Ig superfamily member
, immunoglobulin superfamily member
, CAM-related/down-regulated by oncogenes
, immunoglobulin superfamily member CDO
, oncogene-regulated cell adhesion molecule
, Cdon homolog (mouse)