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cullin-5 and cullin-2 (Montrer CUL2 Protéines) play a role in the development of neuromuscular junction and the female germ line of Drosophila
Data show that the follicular epithelium that normally encapsulates single germ line cysts develops aberrantly in cul-5 mutant.
cul-5 plays multiple roles in cell fate specification and synapse formation during Drosophila development.
CUL5 may be an important part of the mechanism for thalidomide-dependent inhibition.
These findings report genetic variants possibly associated with susceptibility to HIV-1 infection (CUL5 rs11212495, rs7103534, rs7117111) and partial viral load control (APOBEC3G (Montrer APOBEC3G Protéines) rs2294367).
structural model suggests that the diverse FIV and HIV-1 Vifs use conserved residues for Cullin 5 binding, FIV Vif (Montrer BTG1 Protéines) binds Cullin 5 independently of zinc, in contrast to HIV-1 Vif (Montrer BTG1 Protéines).
these findings identify Cul-5 as a signaling component that connects an LPS (Montrer IRF6 Protéines)-activated TLR4 (Montrer TLR4 Protéines)-MyD88 (Montrer MYD88 Protéines) complex to TRAF6 (Montrer TRAF6 Protéines) for efficient activation of NF-kappaB (Montrer NFKB1 Protéines)
CUL5 neddylation may allosterically tune polyubiquitin (Montrer UBB Protéines) chain length and topology.
Study found that CUL5 expression was significantly decreased in both endometrioid adenocarcinomas with the more aggressive serous type displaying a higher reduction. Its mRNA and protein overexpression in endometrial cancer cells resulted in decreased cell proliferation.
Studies indicate that Cullin-RING E3 ubiquitin ligases (CRL) are key players of the ubiquitylation pathway.
These results provide important information on the assembly of the Vif (Montrer BTG1 Protéines)-CUL5-E3 ubiquitin ligase (Montrer MUL1 Protéines) and identify a new viV binding interface with CBF-beta (Montrer CBFB Protéines) at the C-terminus of HIV-1 Vif (Montrer BTG1 Protéines).
Data indicate that cell surface adhesion molecules VCAM-1 (Montrer VCAM1 Protéines) and P-selectin (Montrer SELP Protéines) play some roles in mechanical stretch-induced HL-60 cell adhesion to mouse common carotid arteries.
N-terminal mutants of HIV-1 vif (Montrer BTG1 Protéines) that demonstrated reduced Cul5 binding were also unable to degrade APOBEC3G (Montrer APOBEC3G Protéines) as well as APOBEC3F (Montrer APOBEC3F Protéines).
neural precursor cell expressed developmentally downregulated (Montrer NEDD8 Protéines) protein 8 (Nedd8 (Montrer NEDD8 Protéines)) modification of Cul-5 is required for its interaction with TRAF6 (Montrer TRAF6 Protéines).
Our results show that endogenous Cul5 suppresses epithelial cell transformation by several pathways, including inhibition of Src (Montrer SRC Protéines)-Cas (Montrer CTNND1 Protéines)-induced ruffling through SOCS6 (Montrer SOCS6 Protéines)
The expression of cullin5 on retinal cells and reduction in the percentage of dead retinal cells induced by L-glutamate (Montrer GRIN1 Protéines) suggest that cullin5 has neuroprotective properties in retinal cells.
SOCS (Montrer CISH Protéines) box acts as an independent binding domain capable of recruiting elonginBC and cullin5 to promote E3 ligase formation.
The role of Cul5 is to degrade disabled homolog 1 (Dab1 (Montrer DAB1 Protéines)) and thus control neuron migration speed and neuron insertion at the top of the cortical plate.
These results suggest that, when Src (Montrer SRC Protéines) is activated by mutation or physiological mechanisms, its effects are limited by Culllin 5, which downregulates active Src (Montrer SRC Protéines) and its phosphorylated substrates.
data imply the existence of two distinct subclasses of SOCS (Montrer CISH Protéines) proteins with a high affinity for Cullin5, the E3 ligase scaffold, possibly reflecting complete dependence upon ubiquitination for suppression of cytokine signalling
The study results suggest that VACM-1 may regulate endothelial AQP1 concentration both in vivo and in vitro.
oocyte maturation from pachytene exit and MPK-1 (Montrer MAPK1 Protéines) activation are redundantly controlled by the RBX-2-CUL-5- and RBX-1 (Montrer RBX1 Protéines)-CUL-2 (Montrer CUL2 Protéines)-based complexes.
neuropeptide arginine vasopressin receptor\; may have a role in the central nervous system
Vasopressin-activated calcium-mobilizing receptor (VACM-1)
, cullin 5
, Vasopressin-activated calcium-mobilizing receptor-1
, Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1)
, vasopressin-activated calcium-mobilizing receptor 1
, vasopressin-activated calcium-mobilizing receptor protein
, vasopressin-activated calcium-mobilizing protein