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anti-Mouse (Murine) DDIT3 Anticorps:
anti-Rat (Rattus) DDIT3 Anticorps:
anti-Human DDIT3 Anticorps:
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Human Monoclonal DDIT3 Primary Antibody pour GS, ICC - ABIN269517
Hull, Zraika, Udayasankar, Aston-Mourney, Subramanian, Kahn: Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress. dans Diabetologia 2009
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Human Polyclonal DDIT3 Primary Antibody pour IHC, IHC (p) - ABIN4313145
Nashine, Liu, Kim, Clark, Pang: Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury. dans Investigative ophthalmology & visual science 2015
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Human Polyclonal DDIT3 Primary Antibody pour IF (p), IHC (p) - ABIN685447
Du, Zhou, Jia, Huang: SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. dans Archives of biochemistry and biophysics 2010
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Mouse (Murine) Monoclonal DDIT3 Primary Antibody pour IP, WB - ABIN2668558
Wang, Kuroda, Sok, Batchvarova, Kimmel, Chung, Zinszner, Ron: Identification of novel stress-induced genes downstream of chop. dans The EMBO journal 1998
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Human Polyclonal DDIT3 Primary Antibody pour ELISA, WB - ABIN560585
Hong, Kim, Kim, Lee, Shin, Son, Han, Sung, Kwon: Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells. dans Biochemical pharmacology 2007
Human Monoclonal DDIT3 Primary Antibody pour ELISA, WB - ABIN560586
Kemmner, Kessel, Sanchez-Ruderisch, Möller, Hinderlich, Schlag, Detjen: Loss of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) induces apoptotic processes in pancreatic carcinoma cells. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
Human Polyclonal DDIT3 Primary Antibody pour IP, IHC - ABIN223141
Zenkel, Kruse, Naumann, Schlötzer-Schrehardt: Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. dans Investigative ophthalmology & visual science 2007
Study indicates that CHOP deficiency protects against Western diet-induced AoV calcification in Apoe (Montrer APOE Anticorps)(-/-) mice. CHOP deficiency prevents oxLDL-induced VIC (Montrer EDN2 Anticorps) osteoblastic differentiation via preventing VIC (Montrer EDN2 Anticorps)-derived ABs releasing.
these results suggest that CHOP plays a critical role in the progression of kidney fibrosis, likely through regulation of autophagy and apoptosis.
Atg7 (Montrer ATG7 Anticorps) ablation mainly induced the PERK (Montrer EIF2AK3 Anticorps)-ATF4 (Montrer ATF4 Anticorps)-CHOP axis of the endoplasmic reticulum (ER) stress response in growth plate chondrocytes.
These results suggest JUN (Montrer JUN Anticorps) and DDIT3 are independently regulated pro-death signaling molecules in retinal ganglion cells and together account for the vast majority of apoptotic signaling in retinal ganglion cells after axonal injury
We demonstrated that PPARalpha (Montrer PPARA Anticorps) activation contributes to liver protection and decreases liver inflammation in acute liver failue (ALF (Montrer GTF2A1L Anticorps)), particularly through regulating CHOP. Our findings may provide a rationale for targeting PPARalpha (Montrer PPARA Anticorps) as a potential therapeutic strategy to ameliorate ALF (Montrer GTF2A1L Anticorps).
This study was undertaken to explore the mechanism whereby ERK5 (Montrer MAPK7 Anticorps) inhibition instigates pancreatic beta-cell apoptosis via an endoplasmic reticulum stress-dependent signaling pathway.
ER stress is induced early in EAE and that modulation of ER stress by inhibition of eIF2alpha (Montrer EIF2A Anticorps)-CHOP and activation of XBP-1 (Montrer XBP1 Anticorps) in RGC specifically, protects RGC somata and axons and preserves visual function.
Constitutive overexpression of the CHOP protein does not induce apoptosis in myelinating glia of the central and peripheral nervous systems
Results identify endoplasmic reticulum stress as an age-dependent modifier of islet survival and function by mechanisms implicating enhancement of CHOP activity and inhibition of the protective activity of p21 (Montrer D4S234E Anticorps).
Activation of the ER stress execution proteins, PERK (Montrer EIF2AK3 Anticorps) and CHOP10, was evaluated to determine whether this process was involved in 15d-PMJ2 cell death. 15d-PMJ2 increased the phosphorylation of PERK (Montrer EIF2AK3 Anticorps) and expression of CHOP10 in tumorigenic but not nontumorigenic cells
CHOP/GADD153-dependent apoptosis reflects expression of micro-RNA, miR (Montrer MLXIP Anticorps)-216b.
These results indicated activation of Unfolded Protein Response (UPR) in different cell types derived from Gaucher disease patients, highlighting the generality of this process in this disease. They also showed that the UPR-regulated CHOP transcription factor induces transcription of the GBA1 (Montrer GBA Anticorps) gene.
activation of the IGF-IR/PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps) signaling system is a common pattern in MLS which appears to be transcriptionally controlled, at least in part by induction of IGF2 gene transcription in a FUS (Montrer FUS Anticorps)-DDIT3-dependent manner.
GRP78 (Montrer HSPA5 Anticorps) silencing promoted lung epithelial cell apoptosis during hyperoxia, via regulation of the CHOP pathway.
siRNA silencing of CHOP significantly reduced cyproterone acetate-induced DR5 (Montrer TNFRSF10B Anticorps) up-regulation and TRAIL sensitivity in prostate cancer cells. Our study shows a novel effect of cyproterone acetate on apoptosis pathways in prostate cancer cells and raises the possibility that a combination of TRAIL with cyproterone acetate could be a promising strategy for treating castration-resistant prostate cancer
asthmatic patients exhibited aberrant Chop expression along with endoplasmic reticulum stress
GPR4 (Montrer GPR4 Anticorps) blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression.
Endoplasmic reticulum stress-induced CHOP activation in the brain is a mechanistic link in the palmitate-induced negative regulation of leptin (Montrer LEP Anticorps) and IGF1 (Montrer IGF1 Anticorps).
CHOP negatively regulates Polo-like kinase 2 (Montrer PLK2 Anticorps) expression via recruiting C/EBPalpha (Montrer CEBPA Anticorps) to the upstream-promoter in human osteosarcoma cell line during ER stress
CHOP (GADD153) is an inhibitor of Wnt (Montrer WNT2 Anticorps)/TCF (Montrer HNF4A Anticorps) signals
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
C/EBP homoologous protein 10
, C/EBP zeta
, CCAAT/enhancer-binding protein homologous protein
, DNA damage-inducible transcript 3 protein
, c/EBP-homologous protein 10
, growth arrest and DNA-damage-inducible protein GADD153
, C/EBP homologous protein
, growth arrest and DNA damage-inducible protein GADD153
, growth arrest and DNA damage-inducible
, transcription factor GADD153
, C/EBP-homologous protein 10
, DNA-damage inducible transcript 3